mGluR Inhibitors

mGluR1

mGluR2

mGluR3

mGluR4

mGluR5

mGluR6

mGluR7

mGluR8

mGluR

mGluR Inhibitors, Agonists, Antagonists, Activators & Modulators

Product Name	mGluR1	mGluR2	mGluR3	mGluR4	mGluR5	mGluR6	mGluR7	mGluR8	mGluR	Purity
L-Glutamine									mGluR	≥98.0%
Xanthurenic acid		mGluR2	mGluR3							99.94%
Ro 67-7476	mGluR1a, EC₅₀: 60.1 nM									99.67%
LY341495	mGluR1a, IC₅₀: 7.8 μM	mGluR2, IC₅₀: 21 nM	mGluR3, IC₅₀: 14 nM	mGluR4, IC₅₀: 22 μM	mGluR5a, IC₅₀: 8.2 μM		mGluR7, IC₅₀: 990 nM	mGluR8, IC₅₀: 170 nM		99.50%
VU6043653					human mGluR5, IC₅₀: 325 nM
DHPG	mGluR 1				mGluR 5					99.65%
β-N-methylamino-L-alanine hydrochloride			mGluR3							≥98.0%
MPEP Hydrochloride					mGluR5, IC₅₀: 36 nM					99.82%
LY379268		hmGluR2, EC₅₀: 2.69 nM hmGluR2, Ki: 14.1 nM	hmGluR3, EC₅₀: 4.48 nM hmGluR3, Ki: 5.8 nM							99.84%
Eglumegad		mGluR2R, IC₅₀: 5 nM	mGluR3R, IC₅₀: 24 nM							99.88%
O-Phospho-L-serine	mGluR1	mGluR2		mGluR4		mGluR6	mGluR7	mGluR8		≥98.0%
MTEP hydrochloride					mGluR5, IC₅₀: 5 nM mGluR5, Ki: 16 nM					99.81%
JNJ16259685	mGluR1, IC₅₀: 19 nM									98.66%
MPEP					mGluR5, IC₅₀: 36 nM					99.33%
(S)-MCPG									mGluR	99.02%
CHPG sodium salt					mGlu₅					99.25%
NPS 2390	mGluR1				mGluR5					98.83%
(RS)-MCPG									mGluR	99.05%
DL-AP3	mGluR 1				mGluR 5					≥98.0%
LY2794193		mGluR2, EC₅₀: 47.5 mGluR2, Ki: 412	mGluR3, EC₅₀: 0.47 nM mGluR3, Ki: 0.927 nM							98.16%
VU0650786			mGluR3, IC₅₀: 392 nM							99.97%
LY367385 hydrochloride	mGluR1a, IC₅₀: 8.8 μM									99.44%
CTEP					mGlu5 Receptor, IC₅₀: 2.2 nM					99.19%
Dipraglurant					mGluR5, IC₅₀: 21 nM					99.90%
Basimglurant					mGlu5 Receptor, Kd: 1.1 nM					99.56%
Quisqualic acid	mGluR1R, EC₅₀: 45 nM mGluR1R, Ki: 10 nM	mGluR2R, IC₅₀: 108 μM mGluR2R, Ki: 113 μM		mGluR4R, IC₅₀: 593 μM mGluR4R, Ki: 112 μM						≥98.0%
CDPPB					mGluR5, EC₅₀: 27 nM					99.32%
MMPIP hydrochloride							mGlu7			99.10%
VU0422288				mGluR4, EC₅₀: 108 nM			mGluR7, EC₅₀: 146 nM	mGluR8, EC₅₀: 128 nM		99.88%
Mavoglurant					mGluR5, IC₅₀: 30 nM					99.88%
JNJ-46778212					mGlu5 Receptor, EC₅₀: 260 nM					99.37%
CPPG									group II mGlu receptors, IC₅₀: 46.2 nM group III mGlu receptors, IC₅₀: 2.2 nM	≥99.0%
Cinnabarinic acid				mGluR4						98.74%
L-Cysteinesulfinic acid	mGluR1, pEC₅₀: 3.92	mGluR2, pEC₅₀: 3.9		mGluR4, pEC₅₀: 2.7	mGluR5, pEC₅₀: 4.6	mGluR6, pEC₅₀: 4.0		mGluR8, pEC₅₀: 3.94		99.81%
CHPG					mGlu₅					≥99.0%
RO0711401	mGluR1, EC₅₀: 56 nM									98.42%
ADX88178				mGluR4, EC₅₀: 4 nM						99.69%
LY404039		mGlu2 Receptor, Ki: 149 nM (Recombinant human mGluR2)	hmGluR3, Ki: 92 nM							≥98.0%
Foliglurax monohydrochloride				mGlu₄, EC₅₀: 79 nM						98.93%
JNJ-40411813		mGlu2 Receptor, EC₅₀: 147 nM								99.26%
Fenobam					rat mGluR5, Kd: 54 nM human mGluR5, Kd: 31 nM mGluR5, IC₅₀: 84 nM					99.91%
mGluR2 antagonist 1		mGluR2, IC₅₀: 9 nM								99.31%
(S)-3,5-DHPG	mGluR1a, Ki: 0.9 μM				mGluR5a, Ki: 3.9 μM					≥99.0%
L-AP4				mGlu₄, EC₅₀: 0.13 μM		mGlu₆, EC₅₀: 1.0 μM	mGlu7, EC₅₀: 249 μM	mGlu8, EC₅₀: 0.29 μM		99.01%
VU0361737				Human mGlu₄, EC₅₀: 240 nM Rat mGlu₄, EC₅₀: 110 nM						99.79%
FITM	mGlu1, Ki: 2.5 nM									99.85%
Lu AF21934				mGlu4 Receptor, EC₅₀: 500 nM						99.99%
CVN636							hu mGluR7, EC₅₀: 7 nM			99.47%
VU6010572			mGluR3, IC₅₀: 245 nM							99.82%
VU0364770				Rat mGlu₄, EC₅₀: 290 nM Human mGlu₄, EC₅₀: 1.1 μM	mGlu₅, EC₅₀: 17.9 μM	mGlu₆, EC₅₀: 6.8 μM				99.94%
VU6005649							mGlu7 Receptor, EC₅₀: 0.65 μM	mGlu8 Receptor, EC₅₀: 2.6 μM		99.53%
VU0483605	Human mGluR1, EC₅₀: 390 nM rat mGluR1, EC₅₀: 356 nM			Human mGlu₄, EC₅₀: >10 μM
ADX-47273					mGluR5, EC₅₀: 0.17 μM					99.94%
Pomaglumetad methionil hydrochloride		mGluR2	mGluR3							≥98.0%
ML289			mGluR3, IC₅₀: 0.66 μM							98.38%
SIB-1757					human mGluR5, IC₅₀: 0.4 μM					98.12%
CPCCOEt	mGluR1b									98.31%
VU0155041				Human mGlu₄, EC₅₀: 798 nM Rat mGlu₄, EC₅₀: 693 nM						99.10%
Ro 01-6128	mGluR 1									99.87%
UPF-523	mGluR1a, IC₅₀: 214 μM									99.89%
VU 0364439				mGlu4 Receptor, EC₅₀: 19.8 nM						98.36%
VU6012962							mGlu7, IC₅₀: 347 nM			99.92%
VU-29	rat mGluR1, EC₅₀: 557 nM	rat mGluR2, EC₅₀: 1.5 μM		hmGluR4, EC₅₀: 154 nM	rat mGluR5, EC₅₀: 9 nM rat mGluR5, Ki: 224 nM					99.63%
(RS)-APICA		mGluR2								99.99%
E4CPG									mGluR	≥98.0%
DCG-IV	mGluR1R, IC₅₀: 389 μM	mGluR2R, EC₅₀: 0.35 μM	mGluR3R, EC₅₀: 0.09 μM	mGluR4R, IC₅₀: 22.5 μM	mGluR5, IC₅₀: 630 μM	mGluR6, IC₅₀: 39.6 μM	mGluR7, IC₅₀: 40.1 μM	mGluR8, IC₅₀: 32 μM		≥99.0%
trans-ACPD									mGluR	≥98.0%
ABP688					human mGluR5, Ki: 1.7 nM					98.02%
VU0360172					mGluR5, EC₅₀: 16 nM mGluR5, Ki: 195 nM					98.07%
CPPHA					mGlu5 Receptor					98.04%
PHCCC									Group I mGluR receptors, IC₅₀: 3 μM	99.92%
mGluR2 modulator 1		mGluR2, EC₅₀: 0.03 ± 0.0 μM								≥98.0%
AZD-8529		mGluR2, EC₅₀: 285 nM								98.02%
LY3020371 hydrochloride		mGluR2, Ki: 5.3 nM	mGluR3, Ki: 2.5 nM							99.18%
ADX71743							mGlu7			99.30%
L-Cysteinesulfinic acid monohydrate	mGluR1, pEC₅₀: 3.92	mGluR2, pEC₅₀: 3.9		mGluR4, pEC₅₀: 2.7	mGluR5, pEC₅₀: 4.6	mGluR6, pEC₅₀: 4.0		mGluR8, pEC₅₀: 3.94		99.81%
YM-298198 hydrochloride	mGluR 1									99.61%
(RS)-PPG				hmGluR4a, EC₅₀: 5.2 μM		hmGluR6, EC₅₀: 4.7 μM	hmGluR7b, EC₅₀: 185 μM	hmGluR8a, EC₅₀: 0.2 μM
ML337			mGluR3, IC₅₀: 593 nM							99.13%
JNJ-42153605		mGluR2, EC₅₀: 17 nM								99.24%
Decoglurant		mGluR2	mGluR3							98.78%
Methoxy-PEPy					mGlu5 Receptor, IC₅₀: 1 nM					98.19%
AZD-8529 mesylate		mGluR2, EC₅₀: 285 nM								99.63%
FPTQ	Human mGluR1, IC₅₀: 6 nM Mouse mGluR1, IC₅₀: 1.4 nM									99.92%
HTL14242					mGlu₅					98.58%
CFMTI	Human mGluR1a, IC₅₀: 2.6 nM Rat mGluR1a, IC₅₀: 2.3 nM									≥98.0%
JNJ-46281222		mGluR2, Kd: 1.7 nM								98.77%
(R)-ADX-47273					mGlu₅, EC₅₀: 168 nM					99.00%
FTIDC	mGluR1a, IC₅₀: 5.8 nM				mGlu₅, IC₅₀: 6200 nM
AZ 12216052								mGlu8		98.73%
ML353					mGlu₅, Ki: 18.2 nM					98.07%
VU0080241				mGlu₄, EC₅₀: 4.6 μM						99.69%
AZD 2066					mGluR5					99.8%
Oxomemazine	mGluR 1, Ki: 84 nM	mGluR2, Ki: 1.65 μM								99.18%
LY2979165		mGlu2 Receptor								98.10%
(1R,2S)-VU0155041				mGluR4
Auglurant					rat mGluR5, IC₅₀: 11 nM human mGluR5, IC₅₀: 14 nM					99.40%
BMT-145027					mGluR5, EC₅₀: 47 nM
DCB					mGluR 5					98.81%
VU0409106					mGlu₅, IC₅₀: 24 nM					99.76%
VU6004909	Human mGluR1, EC₅₀: 25.7 nM rat mGluR1, EC₅₀: 31 nM									99.40%
(2R,4R)-APDC									group II mGlu receptors
TASP0433864		hmGluR2, EC₅₀: 199 nM rat mGluR2, EC₅₀: 206 nM								99.9%
VU0469650	mGluR 1, IC₅₀: 99 nM									98.70%
MFZ 10-7					rat mGluR5, Ki: 0.67 nM					99.70%
AZD6538					rat mGluR5, IC₅₀: 3.2 ± 0.1 nM human mGluR5, IC₅₀: 13.4 ± 1.3 nM
VU0364770 hydrochloride				Rat mGlu₄, EC₅₀: 290 nM Human mGlu₄, EC₅₀: 1.1 μM	mGlu₅, EC₅₀: 17.9 μM	mGlu₆, EC₅₀: 6.8 μM				99.70%
L-AP4 monohydrate				mGlu₄, EC₅₀: 0.13 μM		mGlu₆, EC₅₀: 1.0 μM	mGlu7, EC₅₀: 249 μM	mGlu8, EC₅₀: 0.29 μM		≥99.0%
AZD 2066 hydrate					mGluR5					≥99.0%
LY3020371		hmGluR2, Ki: 5.26 nM	hmGluR3, Ki: 2.50 nM
VU6001966		mGluR2, IC₅₀: 78 nM	mGluR3, IC₅₀: >30 μM
VU-1545					mGluR5, Ki: 156 nM mGluR5, EC₅₀: 9.6 nM					99.00%
LY2389575 hydrochloride			mGluR3, IC₅₀: 190 nM							99.93%
(S)-3,4-DCPG								hmGluR8a, EC₅₀: 31 nM		≥98.0%
LY2812223		mGluR2, Ki: 144 nM	mGluR3, Ki: 156 nM							≥98.0%
Biphenylindanone A		mGluR2								99.12%
ML254					rat mGluR5, EC₅₀: 9.3 nM rat mGluR5, pEC₅₀: 8.03 nM
A-841720	Human mGluR1, IC₅₀: 10 nM				human mGluR5, IC₅₀: 342 nM					≥98.0%
LY367385	mGluR1a, IC₅₀: 8.8 μM									≥99.0%
TCN238				mGlu4 Receptor, EC₅₀: 1 μM						99.57%
DFMTI	mGluR1									99.04%
Mavoglurant racemate					mGluR5					98.44%
AZD 9272					mGluR5					99.87%
VU 0357121					mGlu5 Receptor, EC₅₀: 33 nM					99.73%
MGS0274		mGluR2	mGluR3
Pomaglumetad methionil		mGluR2	mGluR3
VU6001376				mGlu₄, EC₅₀: 50.1 nM
Foliglurax				mGlu₄, EC₅₀: 79 nM
mGluR2 modulator 4		mGluR2, EC₅₀: 0.8 μM
MMPIP							mGlu7
LY3027788		mGluR2	mGluR3
L-CCG-I		mGluR2, EC₅₀: 0.3 nM
MTEP					mGluR5, IC₅₀: 5 nM mGluR5, Ki: 16 nM
VU0155041 sodium				mGluR4, EC₅₀: 693 nM
Ro 67-4853	Rat mGluR1a, pEC₅₀: 7.16									99.90%
VU0424465					mGlu₅
mGluR2 modulator 3		mGluR2, EC₅₀: 0.87 μM
Fenobam hydrate					human mGluR5, Kd: 31 nM rat mGluR5, Kd: 54 nM mGluR5, IC₅₀: 84 nM
LBG30300		mGlu2 Receptor, EC₅₀: 0.6 nM	mGluR3, EC₅₀: 0.373 μM	mGlu₄, EC₅₀: 0.11 μM		mGlu₆, EC₅₀: 0.28 μM		mGlu8 Receptor, EC₅₀: 0.097 μM
1-Benzyl-APDC		mGluR2, IC₅₀: 200 μM				mGlu₆, EC₅₀: 20 μM
BAY 36-7620	mGluR 1, IC₅₀: 0.16 μM mGluR1a, IC₅₀: 0.38 μM	mGluR2, IC₅₀: 0.14 μM			mGluR 5, IC₅₀: 0.24 μM
EGLU		mGluR2, Kd: 66 μM
mGluR2 modulator 5		mGluR2, IC₅₀: 8.9 nM
MFZ 10-7 hydrochloride					rat mGluR5, Ki: 0.67 nM
MGS0028		mGlu2 Receptor	mGluR3R
cis-ACPD		mGluR2, EC₅₀: 13 μM		mGluR4, EC₅₀: 50 μM
VU 0360223									mGluR, IC₅₀: 61 nM
BOMA					mGluR5, IC₅₀: 3 nM
A-794282	mGluR1
LY 541850		mGluR2, IC₅₀: 0.161 μM	mGluR3, IC₅₀: 1.05 μM
LSN2814617					rat mGluR5, IC₅₀: 42 ± 9 nM human mGluR5, IC₅₀: 52 ± 21 nM
NPEC-caged-LY379268									group II mGlu receptors
mGluR2 modulator 2		mGluR2, EC₅₀: 0.13 μM
VU0360172 hydrochloride					mGluR5, EC₅₀: 16 nM mGluR5, Ki: 195 nM
Pomaglumetad methionil anhydrous		mGluR2	mGluR3
VU0364289					mGlu₅, EC₅₀: 1.6 μM					99.52%
YM-202074 fumarate	rat mGluR1, Ki: 4.8 nM
LY3027788 hydrochloride		mGluR2	mGluR3
VU0366248					mGluR5
VU6024578	rat mGluR1, EC₅₀: 46 nM Human mGluR1, EC₅₀: 54 nM
JF-NP-26					mGlu5 Receptor
LSP4-2022				mGluR4, EC₅₀: 0.11 ± 0.0 μM			mGluR7, EC₅₀: 11.6 ± 1.9 μM	mGluR8, EC₅₀: 29.2 ± 4.2 μM
mGlu4 receptor agonist 1				mGluR4, EC₅₀: 308 ± 35 nM
VU0092273					mGlu₅, EC₅₀: 0.27 μM
VU0463841					mGlu5 Receptor, IC₅₀: 13 nM
Remeglurant					mGluR 5, IC₅₀: 13 nM
AZD-2066 hydrochloride					mGluR5
YM-230888	mGluR 1, Ki: 13 nM
PXT-012253				mGluR4
A-850002	rat mGluR1, Ki: 41 nM
VU0400195				hmGluR4a, EC₅₀: 291 nM
PF-06422913					mGlu₅
(RS)-4C3HPG	mGluR 1	mGluR2	mGluR3
VU0652835					mGlu₅, IC₅₀: 81 nM

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