2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. MTEP

MTEP 是一种有效的、非竞争性和高选择性的 mGluR5 拮抗剂。MTEP 表现出抗抑郁和抗焦虑的作用。MTEP 可以用于帕金森疾病的研究。

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MTEP Chemical Structure

MTEP Chemical Structure

CAS No. : 329205-68-7

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100 mg   询价  
250 mg   询价  

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MTEP 的其他形式现货产品:

Customer Review

Other Forms of MTEP:

MTEP 相关抗体

Top Publications Citing Use of Products

查看 mGluR 亚型特异性产品:

查看所有亚型
mGluR1 mGluR2 mGluR3 mGluR4 mGluR5 mGluR6 mGluR7 mGluR8 mGluR

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MTEP is a potent, non-competitive and highly selective mGluR5 antagonist, with an IC50 of 5 nM and a Ki of 16 nM. MTEP shows antidepressant and anxiolytic-like effects. MTEP can be used for Parkinson's disease research[1][2][3][4]. MTEP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target

mGluR5

5 nM (IC50)

mGluR5

16 nM (Ki)

体外研究
(In Vitro)

MTEP 对 mGluR5 的选择性高于 mGluR1，对其他 mGluR 亚型没有影响，并且比 MPEP (HY-14609A) 有更少的脱靶效应[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MTEP 相关抗体:
体内研究
(In Vivo)

MTEP (0-5 mg/kg, 腹腔注射, 一次) 抑制由 Haloperidol (HY-14538) (0.5 mg/kg, 腹腔注射)诱导的僵直症[2]。
MTEP (0.3-3 mg/kg, 腹腔注射, 一次) 在雄性 C57BL/6J 小鼠中诱导抗抑郁样作用[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (215-315 g, 5-9/group)[2]
Dosage: 1, 3 and 5 mg/kg
Administration: IP, once, injected 60 min after Haloperidol (HY-14538) (0.5 mg/kg/2 ml i.p.)
Result: Inhibited the catalepsy induced by Haloperidol (HY-14538).
Animal Model: Male C57BL/6J mice (23-25 g)[3]
Dosage: 0.3, 1 and 3 mg/kg
Administration: IP, 1 h before the test
Result: Significantly decreased the immobility time of mice in the tail suspension test (TST) by 24%, 41% and 48%, respectively. The efficacy of MTEP used at doses of 1 and 3 mg/kg was not significantly different from that of Imipramine (HY-B1490A) (20 mg/kg, ip), used as a positive standard.
分子量

200.26

Formula

C11H8N2S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MTEP 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MTEP329205-68-7mGluRMetabotropic glutamate receptorsAntidepressantanxiolytic-likeParkinson's diseaseInhibitorinhibitorinhibit

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目录号：
HY-13206A
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