2. Academic Validation
  3. Discovery of biological evaluation of pyrazole/imidazole amides as mGlu5 receptor negative allosteric modulators

Discovery of biological evaluation of pyrazole/imidazole amides as mGlu5 receptor negative allosteric modulators

  • Bioorg Med Chem Lett. 2013 Apr 1;23(7):2134-9. doi: 10.1016/j.bmcl.2013.01.116.
Eunhee Chae 1,  Yong-Je Shin,  Eun-Ju Ryu,  Mi Kyung Ji,  Nahm Ryune Cho,  Ki-Ho Lee,  Hyun Ji Jeong,  Soo-Jin Kim,  Yeonjung Choi,  Kyung Seok Oh,  Chun-Eung Park,  Young Soo Yoon
Affiliations

Affiliation

  • 1 CNS Drug Discovery, Drug Development Center, SK Biopharmaceuticals, Daejeon 305-712, Republic of Korea. Eunhee.chae@sk.com
PMID: 23434029 DOI: 10.1016/j.bmcl.2013.01.116
Abstract

Development of SAR in a 5-aryl-3-acylpyridinyl-pyrazoles and 1-aryl-4-acylpyridinyl imidazoles series of mGlu5 receptor negative allosteric modulators (mGluR5 NAMs) using a functional cell-based assay is described in this Letter. Analysis of the Ligand-lipophilic efficiency (LipE) of compounds provided new insight for the design of potent mGluR5 negative allosteric modulators with anti-depressant activities.

Figures
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z