2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. DCG-IV

DCG-IV 是一种有效的 II 类 mGluRs 受体激动剂，对 mGlu2R 和 mGlu3R 的 EC50 值为 0.35 和 0.09 μM。DCG-IV 也是 I 组 (IC50: mGlu1R/5R=389/630 μM) 和 III 组受体 (IC50: mGlu4R/6R/7R/8R=22.5/39.6/40.1/32 μM) 的竞争性拮抗剂。DCG-IV 具有抗惊厥和神经保护作用。

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DCG-IV Chemical Structure

DCG-IV Chemical Structure

CAS No. : 147782-19-2

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1 mg ￥6437
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DCG-IV 相关抗体

Top Publications Citing Use of Products

查看 mGluR 亚型特异性产品:

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mGluR1 mGluR2 mGluR3 mGluR4 mGluR5 mGluR6 mGluR7 mGluR8 mGluR

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DCG-IV is a potent agonist of group II mGluRs with EC50s of 0.35 and 0.09 μM for mGlu2R and mGlu3R, reapectively. DCG-IV is also a competitive antagonist at group I (IC50: mGlu1R/5R=389/630 μM) and III receptors (IC50: mGlu4R/6R/7R/8R= 22.5/39.6/40.1/32 μM). DCG-IV has anticonvulsive and neuroprotective effects[1][2].

IC50 & Target[1]

mGluR2R

0.35 μM (EC50)

mGluR3R

0.09 μM (EC50)

mGluR1R

389 μM (IC50)

mGluR5

630 μM (IC50)

mGluR4R

22.5 μM (IC50)

mGluR6

39.6 μM (IC50)

mGluR7

40.1 μM (IC50)

mGluR8

32 μM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 EC50
45 nM
Compound: DCG-IV
Agonist activity at rat mGlu2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level after 1 hr by fluorescence microplate reader
Agonist activity at rat mGlu2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level after 1 hr by fluorescence microplate reader
[PMID: 20218620]
体外研究
(In Vitro)

DCG-IV is also an NMDA receptor agonist in the rat cortical slice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DCG-IV 相关抗体:
体内研究
(In Vivo)

DCG-IV (1-10 mg/kg; i.p.) depresses the phencyclidine (PCP)-induced hyperlocomotion[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male ICR mice weighing about 40 g (PCP-induced locomotor activity)[4]
Dosage: 10, 5, or 1 mg/kg
Administration: I.p.
Result: Reduced spontaneous activities of the animals at 10 or 5 mg/kg.
分子量

203.15

Formula

C7H9NO6
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

H2O 中的溶解度 : ≥ 20 mg/mL (98.45 mM)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.9225 mL 24.6124 mL 49.2247 mL
5 mM 0.9845 mL 4.9225 mL 9.8449 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献

DCG-IV 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.9225 mL 24.6124 mL 49.2247 mL 123.0618 mL
5 mM 0.9845 mL 4.9225 mL 9.8449 mL 24.6124 mL
10 mM 0.4922 mL 2.4612 mL 4.9225 mL 12.3062 mL
15 mM 0.3282 mL 1.6408 mL 3.2816 mL 8.2041 mL
20 mM 0.2461 mL 1.2306 mL 2.4612 mL 6.1531 mL
25 mM 0.1969 mL 0.9845 mL 1.9690 mL 4.9225 mL
30 mM 0.1641 mL 0.8204 mL 1.6408 mL 4.1021 mL
40 mM 0.1231 mL 0.6153 mL 1.2306 mL 3.0765 mL
50 mM 0.0984 mL 0.4922 mL 0.9845 mL 2.4612 mL
60 mM 0.0820 mL 0.4102 mL 0.8204 mL 2.0510 mL
80 mM 0.0615 mL 0.3077 mL 0.6153 mL 1.5383 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DCG-IV147782-19-2mGluRMetabotropic glutamate receptorsanticonvulsiveneuroprotective neurotoxicity locomotion behavioralchangesInhibitorinhibitorinhibit

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