2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. VU6010572

VU6010572 是一种有效的选择性 mGlu3 负变构调制器，其 IC50 为 245 nM。VU6010572 是高度 CNS 渗透剂。

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VU6010572 Chemical Structure

VU6010572 Chemical Structure

CAS No. : 2126784-39-0

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥2750
In-stock
5 mg ￥2500
In-stock
10 mg ￥4060
In-stock
25 mg 现货 询价
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

VU6010572 相关抗体

Top Publications Citing Use of Products

查看 mGluR 亚型特异性产品:

查看所有亚型
mGluR1 mGluR2 mGluR3 mGluR4 mGluR5 mGluR6 mGluR7 mGluR8 mGluR

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

VU6010572 is a potent and selective mGlu3 negative allosteric modulator with IC50 of 245 nM. VU6010572 is highly CNS penetrant[1][2].

IC50 & Target

mGluR3

245 nM (IC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 IC50
245 nM
Compound: 4; VU6010572
Negative allosteric modulation of rat mGlu3R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobilization preincubated for 2.5 mins followed by glutamate addition by S3 Fluo-4-AM dye based fluorescence as
Negative allosteric modulation of rat mGlu3R expressed in HEK293 cells co-expressing Galpha15 assessed as decrease in glutamate-induced calcium mobilization preincubated for 2.5 mins followed by glutamate addition by S3 Fluo-4-AM dye based fluorescence as
[PMID: 31358468]
体内研究
(In Vivo)

VU6010572 (3 mg/kg; i.p.) shows robust efficacy[1].
VU6010572 (3 mg/kg; i.p.; 45 minutes) produces lasting anxiolytic-like behavioral effects[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CD-1 mice[1]
Dosage: 3 mg/kg
Administration: I.p.
Result: Showed robust efficacy.
Animal Model: Rats[2]
Dosage: 3 mg/kg
Administration: I.p.; 45 minutes
Result: Produced lasting anxiolytic-like behavioral effects.
分子量

339.36

Formula

C20H18FNO3
CAS 号
性状

固体

颜色

Off-white to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 100 mg/mL (294.67 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.9467 mL 14.7336 mL 29.4672 mL
5 mM 0.5893 mL 2.9467 mL 5.8934 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

VU6010572 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9467 mL 14.7336 mL 29.4672 mL 73.6681 mL
5 mM 0.5893 mL 2.9467 mL 5.8934 mL 14.7336 mL
10 mM 0.2947 mL 1.4734 mL 2.9467 mL 7.3668 mL
15 mM 0.1964 mL 0.9822 mL 1.9645 mL 4.9112 mL
20 mM 0.1473 mL 0.7367 mL 1.4734 mL 3.6834 mL
25 mM 0.1179 mL 0.5893 mL 1.1787 mL 2.9467 mL
30 mM 0.0982 mL 0.4911 mL 0.9822 mL 2.4556 mL
40 mM 0.0737 mL 0.3683 mL 0.7367 mL 1.8417 mL
50 mM 0.0589 mL 0.2947 mL 0.5893 mL 1.4734 mL
60 mM 0.0491 mL 0.2456 mL 0.4911 mL 1.2278 mL
80 mM 0.0368 mL 0.1842 mL 0.3683 mL 0.9209 mL
100 mM 0.0295 mL 0.1473 mL 0.2947 mL 0.7367 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VU60105722126784-39-0VU 6010572VU-6010572mGluRMetabotropic glutamate receptorspotentselectivemGlu3allostericCNSpenetrantInhibitorinhibitorinhibit

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产品名称：
VU6010572
目录号：
HY-122138
需求量：

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