2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. VU0155041 sodium

VU0155041 sodium 是一种有效，选择性的 mGluR4 混合变构激动剂/正变构调节剂 (PAM)，对人和大鼠 mGluR4 的 EC50 值分别为 798 nM 和 693 nM。VU0155041 sodium 有潜力用于帕金森病的研究。

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VU0155041 sodium Chemical Structure

VU0155041 sodium Chemical Structure

CAS No. : 1259372-69-4

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VU0155041 sodium 的其他形式现货产品:

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Other Forms of VU0155041 sodium:

VU0155041 sodium 相关抗体

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mGluR1 mGluR2 mGluR3 mGluR4 mGluR5 mGluR6 mGluR7 mGluR8 mGluR

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

VU0155041 sodium is a potent, selective positive allosteric modulator (PAM) of mGluR4, with EC50s of 798 nM and 693 nM for human and rat mGluR4, respectively. VU0155041 has potential for the research of Parkinson's disease (PD)[1].

IC50 & Target[1]

mGluR4

693 nM (EC50)

体外研究
(In Vitro)

VU0155041 (10 μM) does not affect NMDA receptor currents in striatal medium spiny neurons[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

VU0155041 sodium 相关抗体:
体内研究
(In Vivo)

VU0155041 (31 nmol, 93 nmol; i.c.v.) reverses catalepsy induced by the dopamine D2 receptor antagonist Haloperidol (1.5 mg/kg, i.p.) in rats[1].
VU0155041 (93 nmol, 316 nmol; i.c.v.) reverses Reserpine (HY-N0480) -induced akinesia in rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Third ventricle cannulated (TVC) Male Sprague-Dawley rats (225-255 g)[1]
Dosage: 31, 93 nmol
Administration: I.c.v. injection after the the 1.5 mg/kg of haloperidol treatment 2 h
Result: Decreased the cataleptic effects of haloperidol, and the effects still presented 30 min after infusion.
分子量

338.16

Formula

C14H14Cl2NNaO3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

VU0155041 sodium 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VU01550411259372-69-4VU 0155041VU-0155041mGluRMetabotropic glutamate receptorsmGluR4partial glutamateInhibitorinhibitorinhibit

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产品名称：
VU0155041 sodium
目录号：
HY-14417B
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