2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. MFZ 10-7 hydrochloride

MFZ 10-7 hydrochloride 是一种高效选择性的 mGluR5 负变构调节剂 (NAM)，对大鼠 mGluR5 作用的 Ki 值为 0.67 nM。

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MFZ 10-7 hydrochloride Chemical Structure

MFZ 10-7 hydrochloride Chemical Structure

CAS No. : 1779796-36-9

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MFZ 10-7 hydrochloride 的其他形式现货产品:

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Other Forms of MFZ 10-7 hydrochloride:

MFZ 10-7 hydrochloride 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

MFZ 10-7 hydrochloride is a highly potent and selective mGluR5 NAM (negative allosteric modulator), with a Ki of 0.67 nM for rat mGluR5[1]. MFZ 10-7 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target[1]

rat mGluR5

0.67 nM (Ki)

体外研究
(In Vitro)

与 mGluR5 相比，MFZ 10-7 hydrochloride 对 MAO-B (单胺氧化酶-B 酶)和 TXA2 (血栓烷 A2 受体)的亲和力分别低约 1150 倍和 3000 倍[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

MFZ 10-7 hydrochloride 相关抗体:
体内研究
(In Vivo)

MFZ 10-7 hydrochloride 可降低口服蔗糖自我-给药速率但对总蔗糖摄入量没有影响[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

272.70

Formula

C15H10ClFN2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

MFZ 10-7 hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MFZ 10-71779796-36-9mGluRMetabotropic glutamate receptorsInhibitorinhibitorinhibit

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产品名称：
MFZ 10-7 hydrochloride
目录号：
HY-103575A
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