2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. mGluR2 modulator 2

mGluR2 modulator 2 (compound 2) 是一种有效、具有选择性和口服生物活性的 mGluR2 正向变构调节剂，EC50 为 0.13 μM。mGluR2 modulator 2 可用于抗精神病研究。

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mGluR2 modulator 2 Chemical Structure

mGluR2 modulator 2 Chemical Structure

CAS No. : 1004614-86-1

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mGluR2 modulator 2 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

mGluR2 modulator 2 (compound 2) is a potent, selective and orally bioavailable mGluR2 positive allosteric modulator with an EC50 value of 0.13 μM. mGluR2 modulator 2 can be used for researching antipsychotic[1].

IC50 & Target[1]

mGluR2

0.13 μM (EC50)

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 EC50
22 nM
Compound: 7b
Positive allosteric modulation of rat mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced intracellular calcium release by FLIPR assay
Positive allosteric modulation of rat mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced intracellular calcium release by FLIPR assay
[PMID: 21366332]
分子量

323.41

Formula

C20H22FN3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

mGluR2 modulator 2 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

mGluR2 modulator 21004614-86-1mGluRMetabotropic glutamate receptorsAntipsychoticPositive allosteric modulatorInhibitorinhibitorinhibit

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