2. PROTAC Epigenetics
  3. Ligands for Target Protein for PROTAC Epigenetic Reader Domain
  4. EP300/CBP ligand 2

EP300/CBP ligand 2 (compound S19) 是靶向 CREB ??结合蛋白 (CBP) 和 E1A 相关蛋白 (EP300) 溴结构域的配体。EP300/CBP ligand 2 可作为 PROTAC 结构中的靶蛋白配体，通过 PTOTAC Linker 偶联 E3 泛素连接酶配体，来合成有降解效果的 PROTAC 分子。例如，EP300/CBP ligand 2 能够与偶联物 (E3 泛素酶配体+Linker) Thalidomide-NH-C10-Boc (HY-161961) 偶联，产生 PROTAC 分子 dCE-2 (HY-161958)。

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EP300/CBP ligand 2 Chemical Structure

EP300/CBP ligand 2 Chemical Structure

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EP300/CBP ligand 2 相关抗体

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  • 生物活性

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生物活性

EP300/CBP ligand 2 (compound S19) is a ligand targeting the bromodomain of CREB binding protein (CBP) and E1A-associated protein (EP300). EP300/CBP ligand 2 can be used as a target protein ligand in the PROTAC structure, and can be coupled to the E3 ubiquitin ligase ligand through the PTOTAC Linker to synthesize PROTAC molecules with degradation effects. For example, EP300/CBP ligand 2 can be coupled with the conjugate (E3 ubiquitin enzyme ligand + Linker) Thalidomide-NH-C10-Boc (HY-161961) to produce the PROTAC molecule dCE-2 (HY-161958)[1].

IC50 & Target

EP300/CBP[1]
分子量

358.40

Formula

C20H18N6O
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

EP300/CBP ligand 2 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

EP300/CBP ligand 2Ligands for Target Protein for PROTACEpigenetic Reader DomainTarget Protein-binding MoietyInhibitorinhibitorinhibit

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产品名称：
EP300/CBP ligand 2
目录号：
HY-161960
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