2. Gene
  3. TSPAN1 - tetraspanin 1 Gene

TSPAN1 - tetraspanin 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：四跨膜蛋白 1

种属: Homo sapiens

同用名: NET1; TM4C; TM4SF

基因 ID: 10103 | 基因类型: protein coding

关于 TSPAN1

Cytogenetic location: 1p34.1 Genomic coordinates (GRCh38): 1:46,175,087-46,196,489 (from NCBI)

This gene has 9 transcripts (splice variants), 194 orthologues and 32 paralogues. Biased expression in colon (RPKM 237.8), prostate (RPKM 118.0) and 10 other tissues.

功能概要

由该基因编码的蛋白质是跨膜 4 超家族的成员，也称为四跨膜蛋白家族。这些成员中的大多数是细胞表面蛋白，其特征在于存在四个疏水结构域。这些蛋白质介导在细胞发育、活化、生长和运动的调节中起作用的信号转导事件。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008]

TSPAN1 基因产物(1)

mRNA Protein Name
NM_005727.4 NP_005718.2 tetraspanin-1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21836059 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in protein stabilization IDA
IDA: 通过直接分析推断
21836059 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
12115476 GOA
located in membrane IDA
IDA: 通过直接分析推断
12115476 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
22378020 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
21836059 GOA
located in vesicle IDA
IDA: 通过直接分析推断
21836059 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TSPAN1 蛋白结构

Tetraspannin

Tetraspannin: Tetraspanin family (6 - 239)

  • 0
  • 100
  • 200
  • 241 a.a.
蛋白主名 其他名称

tetraspanin-1

tetraspan 1

重组 TSPAN1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P77260 TSPAN1 Protein, Human (HEK293, His) O60635 (Y110-N211) ≥95%
HY-P77261 TSPAN1 Protein, Human (HEK293, rFc) O60635 (Y110-N211) ≥95%
HY-P77262 TSPAN1 Protein, Human (HEK293, Fc) O60635 (Y110-N211) ≥95%

关联疾病

疾病名称 别名
Retinitis Pigmentosa 76

RP76

Retinitis Pigmentosa, Type 76
Muscle Eye Brain Disease

Muscle-Eye-Brain Disease

Muscle-Eye-Brain Syndrome

Meb

Muscular Dystrophy-Dystroglycanopathy Congenital With Brain And Eye Anomalies A3

Meb Syndrome

Santavuori Congenital Muscular Dystrophy
Muscular Dystrophy-Dystroglycanopathy , Type B, 3

MDDGB3

Muscular Dystrophy-Dystroglycanopathy , Type B3

Muscular Dystrophy, Congenital, Pomgnt1-Related

Muscular Dystrophy-Dystroglycanopathy Type B3

Congenital Muscular Dystrophy Pomgnt1-Related

Muscular Dystrophy-Dystroglycanopathy Congenital With Impaired Intellectual Development B3

Muscular Dystrophy Congenital Pomgnt1-Related

Dystrophy, Muscular, Dystroglycanopathy , Type B3
Muscular Dystrophy-Dystroglycanopathy , Type C, 3

Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2o

MDDGC3

Lgmd2o

Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 15

Lgmdr15

Muscular Dystrophy-Dystroglycanopathy Limb-Girdle Pomgnt1-Related

Muscular Dystrophy, Limb-Girdle, Type 2o

Muscular Dystrophy-Dystroglycanopathy, Limb-Girdle, Pomgnt1-Related

Muscular Dystrophy-Dystroglycanopathy Type C3

Pomgnt1-Related Limb-Girdle Muscular Dystrophy R15

Lgmd Type 2o

Limb-Girdle Muscular Dystrophy Type 2o

Pomgnt1-Related Lgmd R15

Muscular Dystrophy-Dystroglycanopathy Limb-Girdle C3

Dystrophy, Muscular, Limb-Girdle, Type 2o
Congenital Muscular Dystrophy-Dystroglycanopathy Type A3

Congenital Muscular Dystrophy-Dystroglycanopathy With Brain And Eye Anomalies Type A3

Mddga3

Walker-Warburg Syndrome Or Muscle-Eye-Brain Disease, Pomgnt1-Related

Congenital Muscular Dystrophy-Dystroglycanopathy With Brain And Eye Anomalies, Type A3
Muscular Dystrophy-Dystroglycanopathy , Type A, 3

MDDGA3

Muscular Dystrophy-Dystroglycanopathy , Type A3

Walker-Warburg Syndrome Or Muscle-Eye-Brain Disease, Pomgnt1-Related

Muscular Dystrophy-Dystroglycanopathy Congenital With Brain And Eye Anomalies A3

Muscle-Eye-Brain Disease Pomgnt1-Related

Walker-Warburg Syndrome Pomgnt1-Related

Dystrophy, Muscular, Dystroglycanopathy , Type A3
Congenital Muscular Dystrophy-Dystroglycanopathy Type A

Congenital Muscular Alpha-Dystroglycanopathy With Brain And Eye Anomalies

Mddga

Klissencephaly Type 2 With Muscular And Ocular Involvement

Lissencephaly Type 2 With Muscular And Ocular Involvement
Muscular Dystrophy-Dystroglycanopathy

Cmd Due To Dystroglycanopathy

Congenital Muscular Dystrophy Due To Dystroglycanopathy

Mddg

Dystrophy, Muscular, Dystroglycanopathy
Autosomal Recessive Limb-Girdle Muscular Dystrophy

Muscular Dystrophy, Limb-Girdle, Autosomal Recessive
Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder
Abnormality Of Glucagon Secretion

Glucagon Secretion Abnormality

Abnormality Of Secretion Of Glucagon
Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder
Usher Syndrome, Type Iiia

Usher Syndrome Type 3

Ush3

Usher Syndrome Type 3a

USH3A

Usher Syndrome, Type Iii

Usher Syndrome, Type 3

Usher Syndrome, Type 3a

Usher Syndrome Type Iiia

Usher Syndrome 3a

Usher'S Syndrome Type 3

Usher Syndrome Iii

Usher Syndrome Type Iii
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15157 TSPAN1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus TSPAN1 RGD RGD:1303308
Canis familiaris TSPAN1 VGNC VGNC:47910
Felis catus TSPAN1 VGNC VGNC:66624
Mus musculus TSPAN1 MGD MGI:1914055
Bos taurus TSPAN1 VGNC VGNC:36425
Macaca mulatta TSPAN1 VGNC VGNC:79263
Others TSPAN1 NCBI
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