2. Gene
  3. Adora2b - adenosine A2b receptor Gene

Adora2b - adenosine A2b receptor Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：腺苷 A2 b受体

种属: Mus musculus

同用名: A2b; A2BR; A2BAR; AA2BR; ARA2B

基因 ID: 11541 | 基因类型: protein coding

关于 Adora2b

Chromosome 11: 62,139,810-62,157,279 forward strand.GRCm39:CM001004.3

This gene has 1 transcript (splice variant), 200 orthologues, 3 paralogues and is associated with 37 phenotypes. Broad expression in duodenum adult (RPKM 18.), bladder adult (RPKM 15.8) and 2 other tissues.

功能概要

该基因编码的蛋白可启动 G 蛋白偶联受体活性。参与突触小泡胞吐的调节。在多个过程的上游或内部起作用，包括 cGMP 介导的信号传导的正向调节；对非抗原刺激的慢性炎症反应的正向调节；和细胞因子产生的正调节。位于 Schaffer 侧支 - CA1 突触；谷氨酸能突触；和质膜。在突触中活跃。以多种结构表达，包括心血管系统；中枢神经系统;眼睛;泌尿生殖系统；和直觉。与人类 ADORA2B（腺苷 A2b 受体）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables G protein-coupled receptor activity. Involved in regulation of synaptic vesicle exocytosis. Acts upstream of or within several processes, including positive regulation of cGMP-mediated signaling; positive regulation of chronic inflammatory response to non-antigenic stimulus; and positive regulation of cytokine production. Located in Schaffer collateral - CA1 synapse; glutamatergic synapse; and plasma membrane. Is active in synapse. Is expressed in several structures, including cardiovascular system; central nervous system; eye; genitourinary system; and gut. Orthologous to human ADORA2B (adenosine A2b receptor). [provided by Alliance of Genome Resources, Apr 2022]

Adora2b 基因产物(1)

mRNA Protein Name
NM_007413.4 NP_031439.2 adenosine receptor A2b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables G protein-coupled adenosine receptor activity IDA
IDA: 通过直接分析推断
8157966 MGI
enables G protein-coupled receptor activity IMP
IMP: 通过突变表型推断
16841096 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G protein-coupled adenosine receptor signaling pathway IDA
IDA: 通过直接分析推断
8157966 MGI
acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
IMP: 通过突变表型推断
16841096 MGI
acts upstream of cGMP-mediated signaling IMP
IMP: 通过突变表型推断
18340377 MGI
acts upstream of mast cell degranulation IMP
IMP: 通过突变表型推断
11454903 MGI
acts upstream of or within positive regulation of cGMP-mediated signaling IMP
IMP: 通过突变表型推断
18340377 MGI
acts upstream of or within positive regulation of chemokine production IMP
IMP: 通过突变表型推断
18559975 MGI
acts upstream of or within positive regulation of chronic inflammatory response to non-antigenic stimulus IMP
IMP: 通过突变表型推断
16841096 MGI
acts upstream of or within positive regulation of guanylate cyclase activity IMP
IMP: 通过突变表型推断
18340377 MGI
acts upstream of or within positive regulation of interleukin-6 production IMP
IMP: 通过突变表型推断
18559975 MGI
acts upstream of or within positive regulation of mast cell degranulation IMP
IMP: 通过突变表型推断
11454903 MGI
acts upstream of or within positive regulation of vascular endothelial growth factor production IMP
IMP: 通过突变表型推断
18559975 MGI
involved in presynaptic modulation of chemical synaptic transmission EXP
EXP: 通过实验结果推断
25704806 MGI
involved in presynaptic modulation of chemical synaptic transmission IDA
IDA: 通过直接分析推断
25704806 MGI
involved in presynaptic modulation of chemical synaptic transmission IMP
IMP: 通过突变表型推断
25704806 MGI
acts upstream of or within relaxation of vascular associated smooth muscle IMP
IMP: 通过突变表型推断
18340377 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in Schaffer collateral - CA1 synapse EXP
EXP: 通过实验结果推断
25704806 MGI
is active in Schaffer collateral - CA1 synapse IDA
IDA: 通过直接分析推断
25704806 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: 通过突变表型推断
25704806 MGI
is active in glutamatergic synapse EXP
EXP: 通过实验结果推断
25704806 MGI
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
25704806 MGI
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
25704806 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
12817016 MGI
is active in synapse IDA
IDA: 通过直接分析推断
25704806 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Adora2b 蛋白结构

7tmA_Adenosine_R_A2B

7tmA_Adenosine_R_A2B: cd15069 (7 - 300)

7tmA_Adenosine_R_A2B

7tmA_Adenosine_R_A2B: cd15069 (8 - 34)

7tmA_Adenosine_R_A2B

7tmA_Adenosine_R_A2B: cd15069 (41 - 68)

7tmA_Adenosine_R_A2B

7tmA_Adenosine_R_A2B: cd15069 (77 - 107)

7tmA_Adenosine_R_A2B

7tmA_Adenosine_R_A2B: cd15069 (121 - 139)

7tmA_Adenosine_R_A2B

7tmA_Adenosine_R_A2B: cd15069 (178 - 208)

7tmA_Adenosine_R_A2B

7tmA_Adenosine_R_A2B: cd15069 (226 - 256)

7tmA_Adenosine_R_A2B

7tmA_Adenosine_R_A2B: cd15069 (268 - 293)

  • 0
  • 100
  • 200
  • 300
  • 332 a.a.
蛋白主名 其他名称

adenosine receptor A2b

A2b, Rs

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00397 ADORA2B Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00398 Adora2b Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00399 Adora2b Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Adora2b NCBI NCBI:136
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z