2. Gene
  3. ADORA2B - adenosine A2b receptor Gene

ADORA2B - adenosine A2b receptor Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：腺苷 A2b 受体

种属: Homo sapiens

同用名: ADORA2

基因 ID: 136 | 基因类型: protein coding

关于 ADORA2B

Cytogenetic location: 17p12 Genomic coordinates (GRCh38): 17:15,850,362-15,975,746 (from NCBI)

This gene has 2 transcripts (splice variants), 200 orthologues and 3 paralogues. Broad expression in colon (RPKM 1.7), placenta (RPKM 1.2) and 17 other tissues.

功能概要

该基因编码的腺苷受体是 G 蛋白偶联受体超家族的成员。这种完整的膜蛋白在腺苷存在的情况下刺激腺苷酸环化酶活性。这种蛋白质还与参与轴突伸长的 netrin-1 相互作用。该基因位于 17 号染色体上的 Smith-Magenis 综合征区域附近。[RefSeq 提供，2008 年 7 月]

This gene encodes an Adenosine Receptor that is a member of the G protein-coupled receptor superfamily. This integral membrane protein stimulates Adenylate Cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation. The gene is located near the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

ADORA2B 基因产物(7)

mRNA Protein Name
XM_011523661.3 XP_011521963.1 adenosine receptor A2b isoform X4
XM_047435374.1 XP_047291330.1 adenosine receptor A2b isoform X2
XM_047435373.1 XP_047291329.1 adenosine receptor A2b isoform X2
XM_011523659.4 XP_011521961.1 adenosine receptor A2b isoform X2
XM_017024197.3 XP_016879686.1 adenosine receptor A2b isoform X1
NM_000676.4 NP_000667.1 adenosine receptor A2b
XM_047435375.1 XP_047291331.1 adenosine receptor A2b isoform X3
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
29568380 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ADORA2B 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (24 - 290)

  • 0
  • 100
  • 200
  • 300
  • 332 a.a.
蛋白主名 其他名称

adenosine receptor A2b

ADORA2B 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra ADORA2B P29275 ADORA2A Homo sapiens P29274
BRET
29568380
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus
Inner Ear Disease

Labyrinthine Dysfunction

Diseases Of Inner Ear

Labyrinthine Disease

Abnormality Of The Inner Ear

Labyrinth Diseases

Labyrinthine Disorder

Nonfunctioning Labyrinth

Labyrinthine Loss Of Function

Labyrinthine Syndrome

Labyrinthine Disorder Nos
Priapism

Mentulagra

Priapism, Familial Idiopathic

Familial Idiopathic Priapism

Pathologic Erection

Painful Erection
Subacute Leukemia
Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis
Migraine With Or Without Aura 1

Migraine

Migraine With Or Without Aura, Susceptibility To, 1

Migraine Disorder

Migraine Variant

Migraines

Migraine Disorders

Mgr1

Mgau

Ma

Migraine With Or Without Aura

Classic Migraine

Common Migraine

Disorder, Migraine

Headache Migraine

Headache Migrainous

Migraine Headache

Migraine Syndrome

Headache Including Migraine

Migraine, Susceptibility To
Myocardial Stunning
Barre-Lieou Syndrome

Cervicocranial Syndrome

Posterior Cervical Sympathetic Syndrome
Dermatitis, Atopic, 7

ATOD7

Dermatitis, Atopic, Susceptibility To, 7

Atopic Dermatitis 7

Dermatitis, Atopic 7
Cholera

Vibrio Cholerae Infection

Cholera - Vibrio Cholerae

Cholera Due To Vibrio Cholerae

Vibrio Cholerae

Cholera Syndrome

Asiatic Cholera

Epidemic Cholera
Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder
Adenosine Deaminase Deficiency

Ada Deficiency

Ada-Scid

Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency

Adenosine Deaminase Deficient Severe Combined Immunodeficiency

Scid Due To Ada Deficiency

Severe Combined Immunodeficiency Due To Ada Deficiency

Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Negative, Due To Adenosine Deaminase Deficiency

Ada

Scid Due To Adenosine Deaminase Deficiency
Smith-Magenis Syndrome

SMS

Chromosome 17p11.2 Deletion Syndrome

17p11.2 Microdeletion Syndrome

17p11.2 Monosomy

Chromosome 17p Deletion Syndrome

Del(17)

P11.2

17p- Syndrome

Deletion 17p Syndrome

Partial Monosomy 17p
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00397 ADORA2B Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00398 Adora2b Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00399 Adora2b Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus ADORA2B VGNC VGNC:25688
Mus musculus ADORA2B MGD MGI:99403
Canis familiaris ADORA2B VGNC VGNC:37667
Rattus norvegicus ADORA2B RGD RGD:2050
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