1. Gene
  2. Calcr - calcitonin receptor Gene

Calcr - calcitonin receptor Gene

中文名称:降钙素受体

种属: Rattus norvegicus

基因 ID: 116506 | 基因类型: protein coding

关于 Calcr

Primary_assembly 4: 31,661,273-31,736,392 reverse strand.mRatBN7.2:CM026977.1

This gene has 2 transcripts (splice variants), 218 orthologues, 42 paralogues and is associated with 4 phenotypes. Biased expression in Kidney (RPKM 27.7), Brain (RPKM 15.8) and 1 other tissue.

功能概要

该基因编码的蛋白可启动降钙素结合活性和降钙素受体活性。参与腺苷酸环化酶调节 G 蛋白偶联受体信号通路。位于轴突和神经细胞体。该基因的人类直系同源物与骨质疏松症有关。与人类 CALCR(降钙素受体)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables Calcitonin binding activity and Calcitonin receptor activity. Involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway. Located in axon and neuronal cell body. Human ortholog(s) of this gene implicated in osteoporosis. Orthologous to human CALCR (Calcitonin receptor). [provided by Alliance of Genome Resources, Apr 2022]

Calcr 基因产物(2)

mRNA Protein Name
NM_053816.2 NP_446268.2 calcitonin receptor isoform 1b precursor
NM_001034015.1 NP_001029187.1 calcitonin receptor isoform 1a precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calcitonin binding IDA
IDA: 通过直接分析推断
7723741 RGD
enables calcitonin receptor activity IDA
IDA: 通过直接分析推断
7723741 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
7723741 RGD
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: 通过表达模式推断
23110133 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: 通过表达模式推断
23110133 RGD
involved in mononuclear cell differentiation IEP
IEP: 通过表达模式推断
23110133 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
15571671 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
15571671 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Calcr 蛋白结构

HRM

HRM: pfam02793 (85 - 153)

7tmB1_calcitonin_R

7tmB1_calcitonin_R: cd15274 (161 - 471)

7tmB1_calcitonin_R

7tmB1_calcitonin_R: cd15274 (163 - 188)

7tmB1_calcitonin_R

7tmB1_calcitonin_R: cd15274 (197 - 219)

7tmB1_calcitonin_R

7tmB1_calcitonin_R: cd15274 (273 - 300)

7tmB1_calcitonin_R

7tmB1_calcitonin_R: cd15274 (312 - 332)

7tmB1_calcitonin_R

7tmB1_calcitonin_R: cd15274 (347 - 376)

7tmB1_calcitonin_R

7tmB1_calcitonin_R: cd15274 (390 - 417)

7tmB1_calcitonin_R

7tmB1_calcitonin_R: cd15274 (423 - 448)

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  • 533 a.a.
蛋白主名 其他名称

calcitonin receptor

C1A/C1B

CT-R

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Calcr NCBI NCBI:799