Vcp - valosin-containing protein Gene

中文名称：含缬酪肽蛋白

种属: Rattus norvegicus

关于 Vcp

功能概要

该基因编码的蛋白可启动 ATP 水解活性；腺苷核糖核苷酸结合活性；和相同的蛋白质结合活性。参与内质网到高尔基体小泡介导的转运；泛素依赖性蛋白质分解代谢过程的正调控；和突触组织的调节。位于胞质溶胶和内质网中。 VCP-NPL4-UFD1 AAA ATPase 复合体和 VCP-NSFL1C 复合体的一部分。在谷氨酸能突触中活跃。该基因的人类直系同源基因与多种疾病有关，包括 Charcot-Marie-Tooth 病 2Y 型；佩吉特骨病；肌萎缩侧索硬化 14 型；伴有或不伴有额颞叶痴呆的早发性佩吉特骨病的包涵体肌病 1；和包涵体肌炎。与人类 VCP（含缬乐肽的蛋白质）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables ATP hydrolysis activity; adenyl ribonucleotide binding activity; and identical protein binding activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport; positive regulation of ubiquitin-dependent protein catabolic process; and regulation of synapse organization. Located in cytosol and endoplasmic reticulum. Part of VCP-NPL4-UFD1 AAA ATPase complex and VCP-NSFL1C complex. Is active in glutamatergic synapse. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2Y; Paget's disease of bone; amyotrophic lateral sclerosis type 14; inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1; and inclusion body myositis. Orthologous to human VCP (valosin containing protein). [provided by Alliance of Genome Resources, Apr 2022]