2. Cell Cycle/DNA Damage
  3. p97
  4. VCP/p97 inhibitor-1

VCP/p97 inhibitor-1 是一种有效的 VCP/p97 (也称为 Cdc48，CDC-. 48，或 Ter94) 抑制剂，IC50 值为 54.7 nM。VCP/p97 inhibitor-1 导致蛋白质稳态失调并干扰泛素-蛋白酶体系统 (UPS) 对错误折叠多肽的降解。

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VCP/p97 inhibitor-1 Chemical Structure

VCP/p97 inhibitor-1 Chemical Structure

CAS No. : 2630950-38-6

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VCP/p97 inhibitor-1 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

VCP/p97 inhibitor-1 is a potent inhibitor of VCP/p97 (also called Cdc48, CDC-. 48, or Ter94) with an IC50 of 54.7 nM. VCP/p97 inhibitor-1 causes the dysregulation of protein homeostasis and disturbs the degradation of misfolded polypeptides by the ubiquitin-proteasome system (UPS)[1][2].

IC50 & Target

54.7 nM (VCP/p97)[1]
体外研究
(In Vitro)

VCP/p97 inhibitor-1 (compound 17) (3-fold serial dilutions with the highest concentration at 10 μM; 72 hours) has anti-proliferation effect with IC50s of 2.9 and 0.86 μM in A549 and RPMI8226 cells, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

VCP/p97 inhibitor-1 相关抗体:

Cell Viability Assay[1]

Cell Line: A549, RPMI8226 cells
Concentration: 3-fold serial dilutions with the highest concentration at 10 μM
Incubation Time: 72 hours
Result: Showed anti-proliferative rates in A549 and RPMI8226 cells (IC50= 2.9 and 0.86 μM, respectively).
分子量

491.37

Formula

C24H26BN5O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

VCP/p97 inhibitor-1 相关分类

  • 摩尔计算器

  • 稀释计算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VCP/p97 inhibitor-12630950-38-6p97VCPCdc48VCP/p97ubiquitin-proteasome systemhomeostasisboronic acidpyrimidineanti-proliferationA549RPMI8226Inhibitorinhibitorinhibit

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产品名称：
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目录号：
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