2. Cell Cycle/DNA Damage
  3. p97
  4. VCP/p97 inhibitor-1

VCP/p97 inhibitor-1 是一种有效的 VCP/p97 (也称为 Cdc48，CDC-. 48，或 Ter94) 抑制剂，IC50 值为 54.7 nM。VCP/p97 inhibitor-1 导致蛋白质稳态失调并干扰泛素-蛋白酶体系统 (UPS) 对错误折叠多肽的降解。

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VCP/p97 inhibitor-1 Chemical Structure

VCP/p97 inhibitor-1 Chemical Structure

CAS No. : 2630950-38-6

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VCP/p97 inhibitor-1 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

VCP/p97 inhibitor-1 is a potent inhibitor of VCP/p97 (also called Cdc48, CDC-. 48, or Ter94) with an IC50 of 54.7 nM. VCP/p97 inhibitor-1 causes the dysregulation of protein homeostasis and disturbs the degradation of misfolded polypeptides by the ubiquitin-proteasome system (UPS)[1][2].

IC50 & Target

54.7 nM (VCP/p97)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
2.8 μM
Compound: 17
Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
[PMID: 33831696]
RPMI-8226 IC50
0.86 μM
Compound: 17
Cytotoxicity against human RPMI-8226 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
Cytotoxicity against human RPMI-8226 cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
[PMID: 33831696]
体外研究
(In Vitro)

VCP/p97 inhibitor-1 (compound 17) (3-fold serial dilutions with the highest concentration at 10 μM; 72 hours) has anti-proliferation effect with IC50s of 2.9 and 0.86 μM in A549 and RPMI8226 cells, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

VCP/p97 inhibitor-1 相关抗体:

Cell Viability Assay[1]

Cell Line: A549, RPMI8226 cells
Concentration: 3-fold serial dilutions with the highest concentration at 10 μM
Incubation Time: 72 hours
Result: Showed anti-proliferative rates in A549 and RPMI8226 cells (IC50= 2.9 and 0.86 μM, respectively).
分子量

491.37

Formula

C24H26BN5O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

VCP/p97 inhibitor-1 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VCP/p97 inhibitor-12630950-38-6p97VCPCdc48VCP/p97ubiquitin-proteasome systemhomeostasisboronic acidpyrimidineanti-proliferationA549RPMI8226Inhibitorinhibitorinhibit

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产品名称：
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目录号：
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