KUS121 

KUS121, a valosin-containing protein (VCP, p97) modulator with significant neuroprotective effects, attenuates ischemic retinal cell death via suppressing endoplasmic reticulum stress^[1][2].

KUS121 通过防止ATP耗竭，保护神经元在缺氧和葡萄糖剥夺（OGD）条件下免于细胞死亡。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

KUS121 (IVT injection, 25 μg/eye) 在缺血性损伤后7天和14天似乎表现出更好的内层视网膜变薄抑制效果。KUS121 (IVT injection) 在缺血性损伤后对视网膜形态和功能也具有神经保护作用^[1]。
KUS121抑制了外核层的变薄并维持了视觉功能。KUS121（视网膜）抑制内质网应激，激活哺乳动物雷帕霉素靶蛋白，并抑制与疾病相关的凋亡^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

458.44

C₂₂H₁₆FN₄NaO₃S

1357164-52-3

固体

Brown to red

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. KUS121, a VCP modulator, attenuates ischemic retinal cell death via suppressing endoplasmic reticulum stress. Sci Rep. 2017 Mar 20:7:44873.  [Content Brief]

  [2]. Hisanori Kinoshita, et al. KUS121, a valosin-containing protein modulator, attenuates ischemic stroke via preventing ATP depletion. Sci Rep. 2019 Aug 8;9(1):11519.  [Content Brief]

  [3]. Tomoko Hasegawa, et al. Neuoroprotective efficacies by KUS121, a VCP modulator, on animal models of retinal degeneration. Sci Rep. 2016 Aug 9:6:31184.  [Content Brief]