2. Gene
  3. Calcr - calcitonin receptor Gene

Calcr - calcitonin receptor Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：降钙素受体

种属: Mus musculus

同用名: Clr; Ct-r

基因 ID: 12311 | 基因类型: protein coding

关于 Calcr

Chromosome 6: 3,685,680-3,764,714 reverse strand.GRCm39:CM000999.3

This gene has 5 transcripts (splice variants), 218 orthologues, 41 paralogues and is associated with 9 phenotypes. Biased expression in whole brain E14.5 (RPKM 1.5), CNS E18 (RPKM 1.2) and 5 other tissues.

功能概要

该基因编码的蛋白可启动降钙素受体活性。作用于多个过程的上游或内部，包括腺苷酸环化酶激活 G 蛋白偶联受体信号通路；骨化的负调节；和破骨细胞分化。位于顶体小泡和纤毛中。以多种结构表达，包括大脑；性腺;四肢长骨；乳腺原基；和感觉器官。该基因的人类直系同源物与骨质疏松症有关。与人类 CALCR（降钙素受体）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables Calcitonin receptor activity. Acts upstream of or within several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; negative regulation of ossification; and osteoclast differentiation. Located in acrosomal vesicle and cilium. Is expressed in several structures, including brain; gonad; limb long bone; mammary gland primordium; and sensory organ. Human ortholog(s) of this gene implicated in osteoporosis. Orthologous to human CALCR (Calcitonin receptor). [provided by Alliance of Genome Resources, Apr 2022]

Calcr 基因产物(5)

mRNA Protein Name
NM_001042725.1 NP_001036190.1 calcitonin receptor isoform 1a precursor
NM_007588.2 NP_031614.2 calcitonin receptor isoform 1b precursor
NM_001355192.1 NP_001342121.1 calcitonin receptor isoform 1a precursor
NM_001377018.1 NP_001363947.1 calcitonin receptor isoform 1b precursor
NM_001042725.1 NP_001036190.1 calcitonin receptor isoform 1a precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calcitonin receptor activity IDA
IDA: 通过直接分析推断
7988453 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
7988453 MGI
acts upstream of or within negative regulation of ossification IMP
IMP: 通过突变表型推断
14970190 MGI
acts upstream of ossification IMP
IMP: 通过突变表型推断
14970190 MGI
acts upstream of or within osteoclast differentiation IDA
IDA: 通过直接分析推断
7664679 MGI
acts upstream of or within positive regulation of cytosolic calcium ion concentration IDA
IDA: 通过直接分析推断
9753683 MGI
NOT acts upstream of or within regulation of bone resorption IMP
IMP: 通过突变表型推断
14970190 MGI
acts upstream of or within regulation of mRNA stability IDA
IDA: 通过直接分析推断
9002981 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in acrosomal vesicle IDA
IDA: 通过直接分析推断
12704735 MGI
located in cilium IDA
IDA: 通过直接分析推断
12704735 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Calcr 蛋白结构

HRM

HRM: pfam02793 (85 - 153)

7tmB1_calcitonin_R

7tmB1_calcitonin_R: cd15274 (161 - 471)

7tmB1_calcitonin_R

7tmB1_calcitonin_R: cd15274 (163 - 188)

7tmB1_calcitonin_R

7tmB1_calcitonin_R: cd15274 (197 - 219)

7tmB1_calcitonin_R

7tmB1_calcitonin_R: cd15274 (273 - 300)

7tmB1_calcitonin_R

7tmB1_calcitonin_R: cd15274 (312 - 332)

7tmB1_calcitonin_R

7tmB1_calcitonin_R: cd15274 (347 - 376)

7tmB1_calcitonin_R

7tmB1_calcitonin_R: cd15274 (390 - 417)

7tmB1_calcitonin_R

7tmB1_calcitonin_R: cd15274 (423 - 448)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 533 a.a.
蛋白主名 其他名称

calcitonin receptor

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01832 CALCR Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS01833 Calcr Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS01834 Calcr Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Calcr NCBI NCBI:799
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