1. Gene
  2. TRIM60 - tripartite motif containing 60 Gene

TRIM60 - tripartite motif containing 60 Gene

中文名称:含三方基序 60

种属: Homo sapiens

同用名: RNF33; RNF129

基因 ID: 166655 | 基因类型: protein coding

关于 TRIM60

Cytogenetic location: 4q32.3 Genomic coordinates (GRCh38): 4:165,031,999-165,041,749 (from NCBI)

This gene has 5 transcripts (splice variants), 37 orthologues and 80 paralogues. Low expression observed in reference dataset.

功能概要

该基因编码的蛋白质包含一个环指结构域,该结构域存在于多种功能不同的蛋白质中,已知参与蛋白质-蛋白质和蛋白质-DNA 相互作用。该基因的假基因位于超过 6 条染色体上,包括 4 号染色体。已鉴定出编码相同蛋白质的多个选择性剪接变体。[RefSeq 提供,2013 年 1 月]

The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. Pseudogenes of this gene are located on more than six chromosomes including chromosome 4. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2013]

TRIM60 基因产物(2)

mRNA Protein Name
NM_001258025.2 NP_001244954.1 tripartite motif-containing protein 60
NM_152620.3 NP_689833.1 tripartite motif-containing protein 60
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables SUMO-ubiquitin ligase activity IDA
IDA: 通过直接分析推断
33184450 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of non-canonical NF-kappaB signal transduction IDA
IDA: 通过直接分析推断
33184450 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TRIM60 蛋白结构

zf-C3HC4_4

zf-C3HC4_4: zinc finger of C3HC4-type, RING (16 - 56)

zf-B_box

zf-B_box: B-box zinc finger (93 - 133)

PRY

PRY: SPRY-associated domain (297 - 345)

SPRY

SPRY: SPRY domain (347 - 460)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 471 a.a.
蛋白主名 其他名称

tripartite motif-containing protein 60

ring finger protein 129

TRIM60 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TRIM60 Q495X7 LNX1 Homo sapiens Q8TBB1
Y2H Array
32296183
种属内
TRIM60 Q495X7 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
种属内
TRIM60 Q495X7 LNX1 Homo sapiens Q8TBB1
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Hypotrichosis-Lymphedema-Telangiectasia-Renal Defect Syndrome

Glomerulonephritis With Sparse Hair And Telangiectases

Telangiectatic Membranoproliferative Glomerulonephritis

HLTRS

Hypotrichosis-Lymphedema-Telangiectasia-Membranoproliferative Glomerulonephritis Syndrome

Hlt-Renal Defect Syndrome

Glomerulonephritis Sparse Hair Telangiectases

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus TRIM60 VGNC VGNC:80069
Mus musculus TRIM60 MGD MGI:2387430
Rattus norvegicus TRIM60 RGD RGD:2324264
Macaca mulatta TRIM60 VGNC VGNC:100286