AGRP - agouti related neuropeptide Gene

中文名称：刺豚鼠相关神经肽

种属: Homo sapiens

同用名: ART; AGRT; ASIP2

基因 ID: 181 | 基因类型: protein coding

关于 AGRP

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:67,482,571-67,483,547 (from NCBI)

This gene has 1 transcript (splice variant), 179 orthologues, 1 paralogue and is associated with 1 phenotype. Biased expression in adrenal (RPKM 1.6), lung (RPKM 0.8) and 5 other tissues.

功能概要

该基因编码黑皮质素 3 和黑皮质素 4 受体的拮抗剂。它似乎通过黑皮质素受体和/或细胞内钙调节来调节下丘脑对进食行为的控制，因此在体重稳态中发挥作用。该基因的突变与迟发性肥胖有关。[RefSeq 提供，2009 年 12 月]

This gene encodes an antagonist of the melanocortin-3 and melanocortin-4 receptor. It appears to regulate hypothalamic control of feeding behavior via Melanocortin Receptor and/or intracellular calcium regulation, and thus plays a role in weight homeostasis. Mutations in this gene have been associated with late on-set obesity. [provided by RefSeq, Dec 2009]

AGRP 基因产物(1)

mRNA	Protein	Name
NM_001138.2	NP_001129.1	agouti-related protein precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables neuropeptide hormone activity	IDA IDA: 通过直接分析推断	15927146	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in neuropeptide signaling pathway	IDA IDA: 通过直接分析推断	15927146	GOA
involved in regulation of feeding behavior	IDA IDA: 通过直接分析推断	15927146	GOA
involved in regulation of feeding behavior	IMP IMP: 通过突变表型推断	9311920	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in Golgi lumen	IDA IDA: 通过直接分析推断	15927146	GOA
located in extracellular space	IDA IDA: 通过直接分析推断	15927146	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

AGRP 蛋白结构

Agouti

0
100
132 a.a.

蛋白主名

其他名称

agouti-related protein

agouti related protein homolog

重组 AGRP 蛋白

目录号	产品名	蛋白编号	纯度
HY-P75526	AGRP Protein, Human (HEK293, His)	O00253 (A21-T132)	≥95%
HY-P75527	AGRP Protein, Human (48a.a, HEK293, Fc)	O00253 (S85-T132)	≥95%
HY-P75528	AGRP Protein, Human (HEK293, Fc)	O00253 (A21-T132)	≥95%

关联疾病

疾病名称

别名

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
Obesity , Susceptibility To	BMIQ11
Obesity Bmiq11	Obesity, Early-Onset
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Anorexia Nervosa

Anorexia Nervosa, Susceptibility To	ANON
Anorexia Nervosa, Susceptibility To, 1	An
Anorexia Nervosa 1	An - [Anorexia Nervosa]

Overnutrition

Prader-Willi Syndrome

Prader-Labhart-Willi Syndrome	PWS
Willi-Prader Syndrome	Prader-Willi Syndrome Due To Translocation
Prader-Willi Syndrome Due To Imprinting Mutation	Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15
Prader Willi Syndrome	Upd(15)Mat

Leptin Deficiency Or Dysfunction

Morbid Obesity	Obesity Due To Congenital Leptin Deficiency
LEPD	Congenital Leptin Deficiency
Obesity, Morbid	Obesity, Morbid, Due To Leptin Deficiency
Severe Obesity	Obesity, Morbid, Nonsyndromic 1
Leptin Deficiency	Obesity, Severe, Due To Leptin Deficiency
Leptin	Morbid Obesity Due To Leptin Deficiency
Obesity Morbid	Leptin Dysfunction

Eating Disorder

Eating Disorders

Feeding And Eating Disorders

Acquired Metabolic Disease

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-116797	MS15203		99.51%	否
HY-P3561A	Agouti-related Protein (AGRP) (83-132) Amide (human) (TFA)	Inhibitor	96.96%	否
HY-P3561	Agouti-related Protein (AGRP) (83-132) Amide (human)	Antagonist	/	否
HY-RS00465	AGRP Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	AGRP	RGD	RGD:2068
Macaca mulatta	AGRP	VGNC	VGNC:104680
Bos taurus	AGRP	VGNC	VGNC:25743
Mus musculus	AGRP	MGD	MGI:892013
Canis familiaris	AGRP	VGNC	VGNC:37717
Others	AGRP	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

AGRP - agouti related neuropeptide Gene

关于 AGRP

功能概要

AGRP 基因产物(1)

AGRP 蛋白结构

重组 AGRP 蛋白

关联疾病

直系同源

热门区域

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AGRP - agouti related neuropeptide Gene

关于 AGRP

功能概要

AGRP 基因产物(1)

AGRP 蛋白结构

重组 AGRP 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z