2. Gene
  3. Ptpn2 - protein tyrosine phosphatase, non-receptor type 2 Gene

Ptpn2 - protein tyrosine phosphatase, non-receptor type 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Ptpt; TC-PTP

基因 ID: 19255 | 基因类型: protein coding

关于 Ptpn2

功能概要

Enables STAT family protein binding activity and protein tyrosine Phosphatase activity. Involved in several processes, including hemopoiesis; negative regulation of signal transduction; and positive regulation of response to endoplasmic reticulum stress. Acts upstream of or within Insulin Receptor signaling pathway; negative regulation of transcription by RNA polymerase II; and protein dephosphorylation. Located in nucleus. Is expressed in several structures, including genitourinary system; heart; hemolymphoid system gland; lower jaw; and midbrain. Orthologous to human PTPN2 (protein tyrosine Phosphatase non-receptor type 2). [provided by Alliance of Genome Resources, Apr 2022]

Ptpn2 基因产物(2)

mRNA Protein Name
NM_001127177.1 NP_001120649.1 tyrosine-protein phosphatase non-receptor type 2 isoform b
NM_008977.3 NP_033003.1 tyrosine-protein phosphatase non-receptor type 2 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables STAT family protein binding IPI
IPI: 通过物理相互作用推断
26026268 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
16705167 MGI
enables protein tyrosine phosphatase activity IDA
IDA: 通过直接分析推断
15632081 MGI
enables protein tyrosine phosphatase activity IMP
IMP: 通过突变表型推断
14966296 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in B cell differentiation IMP
IMP: 通过突变表型推断
9271584 MGI
involved in T cell differentiation IMP
IMP: 通过突变表型推断
9271584 MGI
involved in erythrocyte differentiation IMP
IMP: 通过突变表型推断
9271584 MGI
involved in glucose homeostasis IMP
IMP: 通过突变表型推断
20484139 MGI
involved in insulin receptor recycling IDA
IDA: 通过直接分析推断
15632081 MGI
acts upstream of or within insulin receptor signaling pathway IMP
IMP: 通过突变表型推断
15632081 MGI
involved in negative regulation of ERK1 and ERK2 cascade IMP
IMP: 通过突变表型推断
15696169 MGI
involved in negative regulation of T cell receptor signaling pathway IMP
IMP: 通过突变表型推断
22080863 MGI
involved in negative regulation of chemotaxis IMP
IMP: 通过突变表型推断
14966296 MGI
involved in negative regulation of inflammatory response IMP
IMP: 通过突变表型推断
14726372 MGI
involved in negative regulation of insulin receptor signaling pathway IMP
IMP: 通过突变表型推断
12612081 MGI
involved in negative regulation of interleukin-2-mediated signaling pathway IMP
IMP: 通过突变表型推断
11909529 MGI
involved in negative regulation of interleukin-4-mediated signaling pathway IMP
IMP: 通过突变表型推断
17210636 MGI
involved in negative regulation of interleukin-6-mediated signaling pathway IMP
IMP: 通过突变表型推断
20484139 MGI
involved in negative regulation of lipid storage IMP
IMP: 通过突变表型推断
20484139 MGI
involved in negative regulation of macrophage colony-stimulating factor signaling pathway IMP
IMP: 通过突变表型推断
16705167 MGI
involved in negative regulation of macrophage differentiation IMP
IMP: 通过突变表型推断
16705167 MGI
involved in negative regulation of platelet-derived growth factor receptor-beta signaling pathway IMP
IMP: 通过突变表型推断
14966296 MGI
involved in negative regulation of positive thymic T cell selection IMP
IMP: 通过突变表型推断
22080863 MGI
involved in negative regulation of protein tyrosine kinase activity IMP
IMP: 通过突变表型推断
21216966 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IPI
IPI: 通过物理相互作用推断
26026268 MGI
involved in negative regulation of tumor necrosis factor-mediated signaling pathway IMP
IMP: 通过突变表型推断
15696169 MGI
involved in negative regulation of type I interferon-mediated signaling pathway IMP
IMP: 通过突变表型推断
11909529 MGI
involved in negative regulation of type II interferon-mediated signaling pathway IMP
IMP: 通过突变表型推断
12138178 MGI
involved in peptidyl-tyrosine dephosphorylation IMP
IMP: 通过突变表型推断
14966296 MGI
involved in positive regulation of PERK-mediated unfolded protein response IMP
IMP: 通过突变表型推断
21216966 MGI
involved in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP
IMP: 通过突变表型推断
21216966 MGI
involved in positive regulation of gluconeogenesis IMP
IMP: 通过突变表型推断
20484139 MGI
acts upstream of or within protein dephosphorylation IDA
IDA: 通过直接分析推断
26026268 MGI
acts upstream of or within protein dephosphorylation IGI
IGI: 通过遗传相互作用推断
26026268 MGI
acts upstream of or within protein dephosphorylation IMP
IMP: 通过突变表型推断
15632081 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in endosome lumen IDA
IDA: 通过直接分析推断
12612081 MGI
located in nucleus IDA
IDA: 通过直接分析推断
21216966 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

tyrosine-protein phosphatase non-receptor type 2

MPTP

T cell protein-tyrosine phosphatase

protein-tyrosine phosphatase PTP-2

重组 Ptpn2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76669 TCPTP Protein, Mouse (sf9, His) Q06180 (S2-N314) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (14)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-145923 Osunprotafib Inhibitor 99.43% 否
HY-148691 PROTAC PTPN2 degrader-1 Degrader 95.01% 否
HY-153446 Tegeprotafib Inhibitor 98.12% 否
HY-153638 PTPN2/1-IN-2 Antagonist 99.56% 否
HY-118925 Holothurin A Inhibitor / 否
HY-149760 PVD-06 Inhibitor / 否
HY-153938 PROTAC PTPN2 degrader-2 / 否
HY-153938A PROTAC PTPN2 degrader-2 TFA / 否
HY-156606 Anticancer agent 142 Inhibitor / 否
HY-156607 Anticancer agent 143 Inhibitor / 否
HY-156608 Anticancer agent 144 Inhibitor / 否
HY-162428 PTPN2/1-IN-3 Inhibitor / 否
HY-163596 PTPN2-IN-1 Inhibitor / 否
HY-RS11421 PTPN2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ptpn2 NCBI NCBI:5771
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z