2. Gene
  3. PTPN2 - protein tyrosine phosphatase non-receptor type 2 Gene

PTPN2 - protein tyrosine phosphatase non-receptor type 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：蛋白酪氨酸磷酸酶非受体 2 型

种属: Homo sapiens

同用名: PTN2; PTPT; TCPTP; TC-PTP; TCELLPTP

基因 ID: 5771 | 基因类型: protein coding

关于 PTPN2

Cytogenetic location: 18p11.21 Genomic coordinates (GRCh38): 18:12,785,478-12,884,237 (from NCBI)

This gene has 21 transcripts (splice variants), 284 orthologues, 35 paralogues and is associated with 4 phenotypes. Ubiquitous expression in appendix (RPKM 7.7), lymph node (RPKM 7.4) and 25 other tissues.

功能概要

该基因编码的蛋白质是蛋白酪氨酸磷酸酶 (PTP) 家族的成员。 PTP 家族的成员共享一个高度保守的催化基序，这对催化活性至关重要。已知 PTP 是调节多种细胞过程的信号分子，包括细胞生长、分化、有丝分裂周期和致癌转化。据报道，表皮生长因子受体和衔接蛋白 Shc 是该 PTP 的底物，这表明在生长因子介导的细胞信号传导中的作用。已发现编码不同亚型的多个选择性剪接转录物变体。已经报道了两个高度相关但经过明显加工的假基因，它们分别定位于 1 号和 13 号染色体。[RefSeq 提供，2011 年 5 月]

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported. [provided by RefSeq, May 2011]

PTPN2 基因产物(5)

mRNA Protein Name
NM_001207013.2 NP_001193942.1 tyrosine-protein phosphatase non-receptor type 2 isoform 4
NM_001308287.1 NP_001295216.1 tyrosine-protein phosphatase non-receptor type 2 isoform 5
NM_002828.4 NP_002819.2 tyrosine-protein phosphatase non-receptor type 2 isoform 1
NM_080422.3 NP_536347.1 tyrosine-protein phosphatase non-receptor type 2 isoform 2
NM_080423.3 NP_536348.1 tyrosine-protein phosphatase non-receptor type 2 isoform 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables integrin binding IPI
IPI: 通过物理相互作用推断
15592458 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12359225 GOA
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
11909529 GOA
enables protein tyrosine phosphatase activity EXP
EXP: 通过实验结果推断
12138178 GOA
enables protein tyrosine phosphatase activity IDA
IDA: 通过直接分析推断
12138178 GOA
enables protein tyrosine phosphatase activity IMP
IMP: 通过突变表型推断
11909529 GOA
enables receptor tyrosine kinase binding IPI
IPI: 通过物理相互作用推断
18819921 GOA
enables syntaxin binding IPI
IPI: 通过物理相互作用推断
23006999 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
15592458 GOA
involved in negative regulation of epidermal growth factor receptor signaling pathway IMP
IMP: 通过突变表型推断
15592458 GOA
involved in negative regulation of interleukin-2-mediated signaling pathway IMP
IMP: 通过突变表型推断
11909529 GOA
involved in negative regulation of interleukin-4-mediated signaling pathway IMP
IMP: 通过突变表型推断
17210636 GOA
involved in negative regulation of interleukin-6-mediated signaling pathway IMP
IMP: 通过突变表型推断
12359225 GOA
involved in negative regulation of type I interferon-mediated signaling pathway IMP
IMP: 通过突变表型推断
11909529 GOA
NOT involved in negative regulation of type II interferon-mediated signaling pathway IDA
IDA: 通过直接分析推断
12138178 GOA
involved in negative regulation of type II interferon-mediated signaling pathway IMP
IMP: 通过突变表型推断
12138178 GOA
involved in negative regulation of tyrosine phosphorylation of STAT protein IDA
IDA: 通过直接分析推断
12359225 GOA
involved in peptidyl-tyrosine dephosphorylation IMP
IMP: 通过突变表型推断
11909529 GOA
involved in regulation of hepatocyte growth factor receptor signaling pathway IMP
IMP: 通过突变表型推断
18819921 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
7593185 GOA
located in endoplasmic reticulum-Golgi intermediate compartment IDA
IDA: 通过直接分析推断
23006999 GOA
located in nucleus IDA
IDA: 通过直接分析推断
7593185 GOA
colocalizes with plasma membrane IDA
IDA: 通过直接分析推断
15592458 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PTPN2 蛋白结构

Y_phosphatase

Y_phosphatase: Protein-tyrosine phosphatase (42 - 274)

  • 0
  • 100
  • 200
  • 300
  • 415 a.a.
蛋白主名 其他名称

tyrosine-protein phosphatase non-receptor type 2

T-cell protein tyrosine phosphatase

PTPN2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PTPN2 P17706 COL5A1 Homo sapiens P20908
Anti Tag CoIP
33961781
种属内
PTPN2 P17706 COL5A1 Homo sapiens P20908
Anti Tag CoIP
28514442
种属间
PTPN2 P17706 q2ghu2_ehrcr Ehrlichia chaffeensis Q2GHU2
Confocal
19273555
种属内
PTPN2 P17706 GHR Homo sapiens P10912
Array
12907755
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 PTPN2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76103 TCPTP Protein, Human (sf9) P17706-1 (N-G&P, M1-N314) ≥95%
HY-P76104 TCPTP Protein, Human (sf9, His-GST) P17706-1 (M1-N314) ≥95%

关联疾病

疾病名称 别名
Oligoarticular Juvenile Idiopathic Arthritis

Oligoarticular Jia

Pauciarticular Chronic Arthritis

Juvenile Pauciarticular Chronic Arthritis
Rheumatoid Factor-Negative Polyarticular Juvenile Idiopathic Arthritis

Juvenile Polyarthritis Without Rheumatoid Factor

Juvenile Rheumatoid Factor-Negative Polyarthritis

Rheumatoid Factor-Negative Polyarticular Jia

Polyarticular Juvenile Idiopathic Arthritis, Rheumatoid Factor Negative
Inflammatory Bowel Disease 20

IBD20
Inflammatory Bowel Disease 1

Inflammatory Bowel Disease 1

IBD1

Crohn Disease-Associated Growth Failure

Crohn Disease

Regional Enteritis

Ulcerative Colitis

Crohn Disease-Associated Growth Failure, Susceptibility To

Inflammatory Bowel Disease 1, Crohn Disease

Bowel Disease, Inflammatory, Type 1
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
Celiac Disease 1

Celiac Disease

Coeliac Disease

Celiac Sprue

Celiac Disease, Susceptibility To

Gluten-Sensitive Enteropathy

Nontropical Sprue

Sprue

CELIAC1

Celiac Disease, Susceptibility To, 1

Celiac Sprue 1

Celiac Sprue, Susceptibility To, 1

Gluten-Sensitive Enteropathy 1

Gluten-Sensitive Enteropathy, Susceptibility To, 1

Idiopathic Steatorrhea

Cœliac Disease

Gluten Intolerance

Gluten-Induced Enteropathy

Gluten Enteropathy

Celiac Disease, Susceptibility To, Type 1

Childhood Celiac Disease

Coeliac Rickets

Gee Disease

Gee-Herter Disease

Heubner-Herter Disease

Idiopathic Steatorrhoea

Thaysen'S Disease

Herter Gee Syndrome
Diabetes Mellitus

Diabetes
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

Obesity , Susceptibility To

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis
Rasopathy

Ras/Mitogen-Activated Protein Kinase Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (14)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-145923 Osunprotafib Inhibitor 99.43% 否
HY-148691 PROTAC PTPN2 degrader-1 Degrader 95.01% 否
HY-153638 PTPN2/1-IN-2 Antagonist 99.56% 否
HY-153446 Tegeprotafib Inhibitor 98.12% 否
HY-118925 Holothurin A Inhibitor / 否
HY-149760 PVD-06 Inhibitor / 否
HY-153938 PROTAC PTPN2 degrader-2 / 否
HY-153938A PROTAC PTPN2 degrader-2 TFA / 否
HY-156606 Anticancer agent 142 Inhibitor / 否
HY-156607 Anticancer agent 143 Inhibitor / 否
HY-156608 Anticancer agent 144 Inhibitor / 否
HY-162428 PTPN2/1-IN-3 Inhibitor / 否
HY-163596 PTPN2-IN-1 Inhibitor / 否
HY-RS11421 PTPN2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus PTPN2 VGNC VGNC:33534
Mus musculus PTPN2 MGD MGI:97806
Felis catus PTPN2 VGNC VGNC:80468
Rattus norvegicus PTPN2 RGD RGD:620710
Canis familiaris PTPN2 VGNC VGNC:45172
Macaca mulatta PTPN2 VGNC VGNC:104236
Others PTPN2 NCBI
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