ELAVL4 - ELAV like RNA binding protein 4 Gene

中文名称：ELAV 样 RNA 结合蛋白 4

种属: Homo sapiens

同用名: HUD; PNEM

基因 ID: 1996 | 基因类型: protein coding

关于 ELAVL4

Cytogenetic location: 1p33-p32.3 Genomic coordinates (GRCh38): 1:50,048,055-50,203,772 (from NCBI)

This gene has 19 transcripts (splice variants), 207 orthologues and 24 paralogues. Biased expression in brain (RPKM 9.5), adrenal (RPKM 2.6) and 2 other tissues.

功能概要

启用 mRNA 3'-UTR AU 富集区结合活性；聚 (A) 结合活性；和 pre-mRNA 内含子富含嘧啶的结合活性。参与 3'-UTR 介导的 mRNA 稳定； RNA 处理；和 3'-UTR 介导的 mRNA 稳定的正调控。预测位于轴突；细胞质；和树突。预计是多核糖体的一部分。预计在谷氨酸能突触中活跃。 [由基因组资源联盟提供，2022 年 4 月]

Enables mRNA 3'-UTR AU-rich region binding activity; poly(A) binding activity; and pre-mRNA intronic pyrimidine-rich binding activity. Involved in 3'-UTR-mediated mRNA stabilization; RNA processing; and positive regulation of 3'-UTR-mediated mRNA stabilization. Predicted to be located in axon; cytoplasm; and dendrite. Predicted to be part of polysomal ribosome. Predicted to be active in glutamatergic synapse. [provided by Alliance of Genome Resources, Apr 2022]

ELAVL4 基因产物(15)

mRNA	Protein	Name
NM_001144774.3	NP_001138246.1	ELAV-like protein 4 isoform 2
NM_001144775.3	NP_001138247.2	ELAV-like protein 4 isoform 3
NM_001144776.3	NP_001138248.1	ELAV-like protein 4 isoform 4
NM_001144777.3	NP_001138249.1	ELAV-like protein 4 isoform 5
NM_001294348.2	NP_001281277.1	ELAV-like protein 4 isoform 6
NM_001324208.2	NP_001311137.1	ELAV-like protein 4 isoform 7
NM_001324209.2	NP_001311138.1	ELAV-like protein 4 isoform 8
NM_001324212.2	NP_001311141.1	ELAV-like protein 4 isoform 13
NM_001324213.2	NP_001311142.1	ELAV-like protein 4 isoform 9
NM_001324214.2	NP_001311143.1	ELAV-like protein 4 isoform 13
NM_001324215.2	NP_001311144.1	ELAV-like protein 4 isoform 10
NM_001324216.1	NP_001311145.1	ELAV-like protein 4 isoform 11
NM_001324217.2	NP_001311146.1	ELAV-like protein 4 isoform 12
NM_001410787.1	NP_001397716.1	ELAV-like protein 4 isoform 14
NM_021952.5	NP_068771.2	ELAV-like protein 4 isoform 1

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables mRNA 3'-UTR AU-rich region binding	IDA IDA: 通过直接分析推断	10710437	GOA
enables mRNA 3'-UTR binding	IDA IDA: 通过直接分析推断	12468554	GOA
enables poly(A) binding	IDA IDA: 通过直接分析推断	12034726	GOA
enables pre-mRNA intronic pyrimidine-rich binding	IDA IDA: 通过直接分析推断	17035636	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	32814053	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in 3'-UTR-mediated mRNA stabilization	IDA IDA: 通过直接分析推断	12034726	GOA
involved in RNA processing	IDA IDA: 通过直接分析推断	17035636	GOA
involved in positive regulation of 3'-UTR-mediated mRNA stabilization	IDA IDA: 通过直接分析推断	18218628	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ELAVL4 蛋白结构

RRM_1

0
100
200
300
380 a.a.

蛋白主名

其他名称

ELAV-like protein 4

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)

重组 ELAVL4 蛋白

目录号	产品名	蛋白编号	纯度
HY-P72180	ELAVL4 Protein, Human (His-SUMO)	P26378-1 (M1-S380)	≥95%

关联疾病

疾病名称

别名

Lambert-Eaton Myasthenic Syndrome

Lambert-Eaton Syndrome	Eaton-Lambert Syndrome
Lems	Lambert Eaton Myasthenic Syndrome
Eaton Lambert Syndrome	Lambert Eaton Syndrome
Myasthenic Syndrome Of Lambert-Eaton	Myasthenic-Myopathic Syndrome Of Lambert-Eaton
Lems - [Lambert-Eaton Myasthenic Syndrome]

Sensory Peripheral Neuropathy

Sensory Neuropathy	Peripheral Sensory Neuropathy
Hereditary Sensory And Autonomic Neuropathies

Hallucinogen Abuse

Paraneoplastic Cerebellar Degeneration

Pcd	Paraneoplastic Cerebellar Ataxia
Rapidely Progressive Cerebellar Syndrome	Subacute Cerebellar Degeneration

Motor Neuron Disease

Anterior Horn Cell Disease	Motor Neuron Diseases
Mnd - [Motor Neurone Disease]	Lou Gehrig Disease
Creeping Palsy	Creeping Paralysis
Bulbar Motor Neuron Disease	Bulbar Syndrome
Anterior Horn Cell Disorder	Hereditary Motor Neuron Disease

Muscular Atrophy

Muscle Wasting	Amyotrophia
Wasting - Muscle	Skeletal Muscle Atrophy

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Small Cell Cancer Of The Lung

Small Cell Lung Cancer	Small Cell Lung Carcinoma
Sclc	Small-Cell Cancer Of Lung
Lung Small Cell Carcinoma	Sclc1
Sccl	Cancer, Lung, Small Cell
Small Cell Carcinoma Of Lung	Carcinoma, Small Cell

Hyperinsulinemic Hypoglycemia, Familial, 4

Hyperinsulinism Due To Glutamodehydrogenase Deficiency	HHF4
Familial Hyperinsulinemic Hypoglycemia 4	Hyperinsulinemic Hypoglycemia Due To Short Chain 3-Hydroxylacyl-Coa Dehydrogenase Deficiency
Hyperinsulinism Due To Schad Deficiency	Hyperinsulinism Due To Short Chain 3-Hydroxylacyl-Coa Dehydrogenase Deficiency
Congenital Hyperinsulinism	Schad Deficiency
Persistent Hyperinsulinemic Hypoglycemia Of Infancy	Phhi
3-Hydroxyacyl-Coa Dehydrogenase Deficiency

Myotonic Disease

Myotonic Disorders	Myotonic Syndrome
Symptomatic Myotonia

Myotonic Dystrophy 1

Myotonic Dystrophy	Dystrophia Myotonica
Steinert Disease	Myotonic Dystrophy Type 1
Myotonia Atrophica	DM1
Congenital Myotonic Dystrophy	Myotonia Dystrophica
Steinert Myotonic Dystrophy	Dystrophia Myotonica 1
Dm	Steinert'S Disease
Steinert Myotonic Dystrophy Syndrome	Myotonic Dystrophy Of Steinert
Dystrophia Myotonica Type 1	Myotonic Dystrophy Congenital
Dystrophy, Myotonic, Type 1	Dm - [Dystrophia Myotonica]
Myotonic Muscular Dystrophy

Neuroblastoma

Nb	Neuroblastoma, Susceptibility To
Neuroblastomas	Central Neuroblastoma

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Autosomal Dominant Cerebellar Ataxia

Spinocerebellar Ataxia	Adca
Pierre Marie Cerebellar Ataxia	Ataxia, Spinocerebellar
Sca	Autosomal Dominant Spinocerebellar Ataxia
Spinocerebellar Ataxias

Neuromuscular Disease

Neuromuscular Diseases	Neuromuscular Disorders
Neuromuscular Disorder

Hirschsprung Disease 1

Hirschsprung Disease	Aganglionic Megacolon
Hscr	Hirschsprung'S Disease
Congenital Megacolon	Congenital Intestinal Aganglionosis
Colonic Aganglionosis	Hirschsprung Disease, Susceptibility To, 1
Hirschsprung Disease, Protection Against	HSCR1
Mgc	Pelvirectal Achalasia
Total Intestinal Aganglionosis	Megacolon, Aganglionic
Macrocolon	Hscr 1
Hirschsprung Disease Type 1	Hirschsprung Disease, Type 1
Congenital Dilatation Of Colon	Aganglionosis
Congenital Aganglionic Megacolon	Aganglionosis Of Colon
Bowel Aganglionosis	Colon Aganglionosis
Hirschsprung Megacolon

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Peripheral Nervous System Disease

Peripheral Neuropathy	Peripheral Nerve Disease
Peripheral Nerve Disorders	Neuropathy, Peripheral
Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS04297	ELAVL4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	ELAVL4	VGNC	VGNC:61804
Rattus norvegicus	ELAVL4	RGD	RGD:1560027
Mus musculus	ELAVL4	MGD	MGI:107427
Macaca mulatta	ELAVL4	VGNC	VGNC:72203
Canis familiaris	ELAVL4	VGNC	VGNC:54201
Bos taurus	ELAVL4	VGNC	VGNC:52769
Others	ELAVL4	NCBI

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

ELAVL4 - ELAV like RNA binding protein 4 Gene

关于 ELAVL4

功能概要

ELAVL4 基因产物(15)

ELAVL4 蛋白结构

重组 ELAVL4 蛋白

关联疾病

直系同源

热门区域

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ELAVL4 - ELAV like RNA binding protein 4 Gene

关于 ELAVL4

功能概要

ELAVL4 基因产物(15)

ELAVL4 蛋白结构

重组 ELAVL4 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z