1. Gene
  2. Sfrp1 - secreted frizzled-related protein 1 Gene

Sfrp1 - secreted frizzled-related protein 1 Gene

中文名称:分泌型卷曲相关蛋白 1

种属: Mus musculus

同用名: sFRP-1; 2210415K03Rik

基因 ID: 20377 | 基因类型: protein coding

关于 Sfrp1

Chromosome 8: 23,901,518-23,939,648 forward strand.GRCm39:CM001001.3

This gene has 1 transcript (splice variant), 223 orthologues, 15 paralogues and is associated with 15 phenotypes. Ubiquitous expression in kidney adult (RPKM 23.7), CNS E11.5 (RPKM 22.8) and 26 other tissues.

功能概要

预计该基因编码的蛋白具有多种功能,包括 Wnt 蛋白结合活性;卷曲的结合活动;和肝素结合活性。参与多个过程,包括细胞对 X 射线的反应;细胞对雌激素刺激的反应;和 B 细胞分化的负调节。作用于多个过程的上游或内部,包括动物器官发育;脊索动物胚胎发育;和信号转导的调节。位于细胞外空间。以多种结构表达,包括消化系统;中枢神经系统;泌尿生殖系统;心;和感觉器官。与人类 SFRP1(分泌的卷曲相关蛋白 1)同源。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable several functions, including Wnt-protein binding activity; Frizzled binding activity; and heparin binding activity. Involved in several processes, including cellular response to X-ray; cellular response to estrogen stimulus; and negative regulation of B cell differentiation. Acts upstream of or within several processes, including animal organ development; chordate embryonic development; and regulation of signal transduction. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Orthologous to human SFRP1 (secreted Frizzled related protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Sfrp1 基因产物(1)

mRNA Protein Name
NM_013834.3 NP_038862.2 secreted frizzled-related protein 1 precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
19188438 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of BMP signaling pathway IGI
IGI: 通过遗传相互作用推断
19850029 MGI
acts upstream of or within Wnt signaling pathway involved in somitogenesis IGI
IGI: 通过遗传相互作用推断
18257070 MGI
acts upstream of or within Wnt signaling pathway, planar cell polarity pathway IDA
IDA: 通过直接分析推断
18371946 MGI
acts upstream of or within anterior/posterior pattern specification IGI
IGI: 通过遗传相互作用推断
16467359 MGI
acts upstream of or within bone trabecula formation IMP
IMP: 通过突变表型推断
14976225 MGI
acts upstream of canonical Wnt signaling pathway IGI
IGI: 通过遗传相互作用推断
18257070 MGI
involved in cellular response to X-ray IDA
IDA: 通过直接分析推断
19778523 MGI
involved in cellular response to estrogen stimulus IDA
IDA: 通过直接分析推断
18941195 MGI
acts upstream of or within convergent extension involved in somitogenesis IGI
IGI: 通过遗传相互作用推断
18257070 MGI
acts upstream of or within development of primary male sexual characteristics IGI
IGI: 通过遗传相互作用推断
19100252 MGI
acts upstream of or within digestive tract morphogenesis IGI
IGI: 通过遗传相互作用推断
19300477 MGI
involved in dopaminergic neuron differentiation IDA
IDA: 通过直接分析推断
22535492 MGI
acts upstream of extrinsic apoptotic signaling pathway IMP
IMP: 通过突变表型推断
14976225 MGI
acts upstream of or within female gonad development IGI
IGI: 通过遗传相互作用推断
19100252 MGI
acts upstream of or within hemopoiesis IMP
IMP: 通过突变表型推断
19664990 MGI
acts upstream of or within male gonad development IGI
IGI: 通过遗传相互作用推断
19100252 MGI
involved in negative regulation of B cell differentiation IMP
IMP: 通过突变表型推断
18941195 MGI
acts upstream of or within negative regulation of BMP signaling pathway IGI
IGI: 通过遗传相互作用推断
19850029 MGI
acts upstream of or within negative regulation of JUN kinase activity IGI
IGI: 通过遗传相互作用推断
19300477 MGI
acts upstream of or within negative regulation of Wnt signaling pathway IGI
IGI: 通过遗传相互作用推断
19300477 MGI
involved in negative regulation of canonical Wnt signaling pathway IDA
IDA: 通过直接分析推断
16149051 MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway IGI
IGI: 通过遗传相互作用推断
17462603 MGI
acts upstream of or within negative regulation of gene expression IMP
IMP: 通过突变表型推断
19850029 MGI
acts upstream of or within negative regulation of ossification IMP
IMP: 通过突变表型推断
19254787 MGI
acts upstream of or within negative regulation of osteoblast differentiation IMP
IMP: 通过突变表型推断
14976225 MGI
acts upstream of or within negative regulation of osteoblast proliferation IMP
IMP: 通过突变表型推断
14976225 MGI
acts upstream of or within negative regulation of osteoclast differentiation IMP
IMP: 通过突变表型推断
14976225 MGI
acts upstream of or within neural crest cell fate commitment IMP
IMP: 通过突变表型推断
20130188 MGI
acts upstream of or within neural tube closure IGI
IGI: 通过遗传相互作用推断
19850029 MGI
acts upstream of or within neural tube development IGI
IGI: 通过遗传相互作用推断
19850029 MGI
acts upstream of osteoclast differentiation IMP
IMP: 通过突变表型推断
14976225 MGI
acts upstream of or within positive regulation of extrinsic apoptotic signaling pathway IMP
IMP: 通过突变表型推断
14976225 MGI
acts upstream of or within prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis IMP
IMP: 通过突变表型推断
18371946 MGI
acts upstream of or within regulation of branching involved in prostate gland morphogenesis IMP
IMP: 通过突变表型推断
18371946 MGI
acts upstream of or within regulation of establishment of planar polarity IGI
IGI: 通过遗传相互作用推断
19300477 MGI
involved in regulation of midbrain dopaminergic neuron differentiation IGI
IGI: 通过遗传相互作用推断
22290867 MGI
involved in regulation of neuron projection development IDA
IDA: 通过直接分析推断
22290867 MGI
involved in response to xenobiotic stimulus IDA
IDA: 通过直接分析推断
19778523 MGI
acts upstream of or within somatic stem cell population maintenance IMP
IMP: 通过突变表型推断
19664990 MGI
involved in somitogenesis IEP
IEP: 通过表达模式推断
10654605 MGI
acts upstream of or within somitogenesis IGI
IGI: 通过遗传相互作用推断
16467359 MGI
involved in stromal-epithelial cell signaling involved in prostate gland development IEP
IEP: 通过表达模式推断
16288033 MGI
involved in ureteric bud development IEP
IEP: 通过表达模式推断
16545622 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Sfrp1 蛋白结构

CRD_SFRP1

CRD_SFRP1: cd07443 (51 - 174)

NTR_Sfrp1_like

NTR_Sfrp1_like: cd03580 (182 - 305)

  • 0
  • 100
  • 200
  • 314 a.a.
蛋白主名 其他名称

secreted frizzled-related protein 1

secreted frizzled-related sequence protein 1

重组 Sfrp1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P73413 SFRP1 Protein, Mouse (CHO, His) AAC53145.1 (S32-K314) ≥95%

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Sfrp1 NCBI NCBI:6422