ERG - ETS transcription factor ERG Gene

中文名称：ETS 转录因子 ERG

种属: Homo sapiens

同用名: p55; erg-3

基因 ID: 2078 | 基因类型: protein coding

关于 ERG

Cytogenetic location: 21q22.2 Genomic coordinates (GRCh38): 21:38,367,261-38,661,783 (from NCBI)

This gene has 15 transcripts (splice variants), 160 orthologues, 28 paralogues and is associated with 120 phenotypes. Broad expression in fat (RPKM 7.8), spleen (RPKM 6.9) and 23 other tissues.

功能概要

该基因编码成红细胞转化特异性 (ETS) 转录因子家族的成员。该家族的所有成员都是胚胎发育、细胞增殖、分化、血管生成、炎症和细胞凋亡的关键调节因子。该基因编码的蛋白质主要在细胞核中表达。它包含一个 ETS DNA 结合结构域和一个 PNT (尖头) 结构域，该结构域与嵌合癌蛋白的自缔合有关。这种蛋白质是血小板粘附到内皮下层、诱导血管细胞重塑所必需的。它还调节造血功能以及巨核细胞的分化和成熟。该基因参与染色体易位，产生不同的融合基因产物，如前列腺癌中的 TMPSSR2-ERG 和 NDRG1-ERG，尤文氏肉瘤中的 EWS-ERG 和急性髓性白血病中的 FUS-ERG。已经报道了组合使用三个替代启动子和多个替代剪接事件产生的超过两打的转录本变体，但尚未确定其中许多变体的全长性质。[RefSeq 提供，2014 年 4 月]

This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and Apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate Cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Apr 2014]

ERG 基因产物(9)

mRNA	Protein	Name
NM_001136154.1	NP_001129626.1	transcriptional regulator ERG isoform 3
NM_001136155.1	NP_001129627.1	transcriptional regulator ERG isoform 4
NM_001243428.1	NP_001230357.1	transcriptional regulator ERG isoform 3
NM_001243429.1	NP_001230358.1	transcriptional regulator ERG isoform 5
NM_001243432.2	NP_001230361.1	transcriptional regulator ERG isoform 6
NM_001291391.1	NP_001278320.1	transcriptional regulator ERG isoform 7
NM_001331025.2	NP_001317954.1	transcriptional regulator ERG isoform 8
NM_004449.4	NP_004440.1	transcriptional regulator ERG isoform 2
NM_182918.4	NP_891548.1	transcriptional regulator ERG isoform 1

ERG 蛋白结构

SAM_PNT

Ets

0
100
200
300
400
479 a.a.

蛋白主名

其他名称

transcriptional regulator ERG

ERG, ETS transcription factor

重组 ERG 蛋白

目录号	产品名	蛋白编号	纯度
HY-P71733	ERG Protein, Human (P.pastoris, His)	P11308-3 (M1-Y486)	≥95%

关联疾病

疾病名称

别名

Ewing Sarcoma

Neuroepithelioma	Ewing'S Tumor
Primitive Neuroectodermal Tumor	Ewings Sarcoma
Ewing'S Sarcoma	Peripheral Neuroepithelioma
ES	Ewings Sarcoma-Primitive Neuroectodermal Tumor
Localized Peripheral Primitive Neuroectodermal Tumor	Peripheral Primitive Neuroectodermal Tumor
Ewing Tumor	Sarcoma, Ewing'S
Ewing Family Of Tumors	Extraosseous Ewing Tumor
Askin Tumor	Ewing'S Family Localized Tumor
Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor	Localized Ewing Sarcoma
Localized Ewing'S Sarcoma	Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor
Localized Ewing'S Tumor	Pnet Of Thoracopulmonary Region
Tumor Of The Ewing Family	Skeletal Ewing Sarcoma
Osseous Ewing Sarcoma	Ppnet
Peripheral Pnet	Extraskeletal Ewing Sarcoma
Eoe	Extraosseous Ewing Sarcoma
Extraskeletal Ewing Tumor	Esft
Ewing Sarcoma Family Of Tumors	Pne
Pnet	Pnet Of The Chest Wall
Sarcoma, Ewing	Neuroectodermal Tumors, Primitive, Peripheral
Neuroectodermal Tumor, Primitive	Disorder Of Eye
Askin'S Tumor	Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor
Neuroepithelioma, Peripheral

Neurofibromatosis-Noonan Syndrome

NFNS	Neurofibromatosis Type 1
Neurofibromatosis With Noonan Phenotype	Nf1
Von Recklinghausen Disease	Neurofibromatosis Type 1-Noonan Syndrome
Noonan Neurofibromatosis Syndrome	Recklinghausen'S Disease
Noonan-Neurofibromatosis Syndrome	Fibromatosis Multiple Non Ossifying
Disseminated Nonossifying Fibromas In Association With Cafe-Au-Lait Spots	Jaffe Campanacci Syndrome
Type 1 Neurofibromatosis	Neurofibromatosis 1
Peripheral Neurofibromatosis	Recklinghausen Disease, Nerve
Jaffe-Campanacci Syndrome

Neurofibromatosis, Type I

Von Recklinghausen Disease	Neurofibromatosis 1
Neurofibromatosis, Type 1	NF1
Neurofibromatosis, Peripheral Type	Neurofibromatosis Type I
Neurofibromatosis Type 1 Due To Nf1 Mutation Or Intragenic Deletion	Familial Spinal Neurofibromatosis
Fsnf	Peripheral Neurofibromatosis
Von Recklinghausen'S Neurofibromatosis	Von Recklinghausen Disease Due To Nf1 Mutation Or Intragenic Deletion
Neurofibromatosis Peripheral Type	Von Recklinghausen Syndrome
Neurofibromatosis Type 1	Von Recklinghausen Neuropathy
Nf1 - [Neurofibromatosis Type 1]	Recklinghausen Disease

Myeloid Leukemia

Myeloid Leukaemia	Leukaemia Myelogenous
Leukemia Myelogenous	Myeloid Granulocytic Leukaemia
Myeloid Granulocytic Leukemia	Non-Lymphocytic Leukemia
Leukemia, Myeloid	Granulocytic Leukaemia
Myelogenous Leukaemia	Myeloid Leukaemia, Unspecified, Without Mention Of Remission

Sarcoma

Connective And Soft Tissue Neoplasm	Tumor Of Soft Tissue And Skeleton
Sarcomas	Sarcoma - Category

Myxoid Liposarcoma

Myxoid/Round Cell Liposarcoma	Liposarcoma, Myxoid
Mrcls	Myxoliposarcoma
MXLIPO	Liposarcoma Myxoid
Liposarcoma

Leukemia

Leukemias	Leukaemia, Unspecified, Without Mention Of Remission
Aleukemic Leukaemia	Chronic Leukaemia
Subacute Leukaemia	Leukaemia Disorder
Leukaemia Nos

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Long Qt Syndrome

Romano-Ward Syndrome	Long Q-T Syndrome
Lqt	Qt Syndrome, Long
Congenital Long Qt Syndrome	Familial Long Qt Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	是否罕见病
HY-A0148A	Halofantrine hydrochloride	Inhibitor	99.89%	是

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-134541	SM-102		99.90%	否
HY-W193545A	ERG240		≥98.0%	否
HY-122234	VPC-18005	Inhibitor	99.32%	否
HY-112158	NSC139021	Inhibitor	99.86%	否
HY-16915	RPR-260243	Activator	99.91%	否
HY-139893	ERGi-USU-6 mesylate	Inhibitor	≥95.0%	否
HY-76542A	5,6-trans-Vitamin D2		98.77%	否
HY-121964	cis-Piperidine-2,3-dicarboxylic acid	Agonist	≥98.0%	否
HY-116445	UNC9975		/	否
HY-134541A	SM-102 (Excipient)		/	否
HY-144694	HDAC/HSP90-IN-3	Inhibitor	/	否
HY-145814	HSP90-IN-9	Inhibitor	/	否
HY-159585	CYP51-IN-20	Inhibitor	/	否
HY-159730	ERG245	Inhibitor	/	否
HY-N7848	Linoleamide		99.4%	否
HY-RS04491	ERG Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS04492	ERG28 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS04493	ERGIC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS04494	ERGIC3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-117523	(Z)-RG-13022	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	ERG	VGNC	VGNC:50174
Canis familiaris	ERG	VGNC	VGNC:40448
Felis catus	ERG	VGNC	VGNC:61937
Rattus norvegicus	ERG	RGD	RGD:621108
Mus musculus	ERG	MGD	MGI:95415
Macaca mulatta	ERG	VGNC	VGNC:72427
Canis lupus familiaris	ERG	NCBI
Others	ERG	NCBI

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