2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. (Z)-RG-13022

(Z)-RG-13022  (Synonyms: (Z)-Tyrphostin RG13022)

目录号: HY-117523
产品使用指南

摩尔计算器

(Z)-RG-13022 是一种酪氨酸激酶 (TK) 抑制剂，优先抑制 EGFR TK 活性，抑制 EGF 刺激的培养细胞生长。(Z)-RG-13022 对 HN5 细胞的 DNA 合成表现出 11 μM 的 IC50，比 (E)-RG-13022 (IC50=38 μM) 强 3 倍以上。(Z)-RG-13022 可用于乳腺癌细胞的研究。

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(Z)-RG-13022 Chemical Structure

(Z)-RG-13022 Chemical Structure

CAS No. : 149286-90-8

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(Z)-RG-13022 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(Z)-RG-13022 is a tyrosine kinase (TK) inhibitor, which inhibits preferentially the TK activity of the EGF receptor and inhibits EGF-stimulated growth of cultured cells. (Z)-RG-13022 exerts an IC50 of 11 μM for DNA synthesis in the HN5 cells, which is 3 times more potent than (E)-RG-13022 (IC50=38 μM). (Z)-RG-13022 can be used for research of breast cancer cells[1][2].

体外研究
(In Vitro)

(Z)-RG-13022 (1-100 μM, 24 h) 剂量依赖性地抑制 HN5 细胞的 DNA 合成，且不影响细胞活力[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

(Z)-RG-13022 相关抗体:
分子量

266.29

Formula

C16H14N2O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(Z)-RG-13022 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Z)-RG-13022149286-90-8(Z)-Tyrphostin RG13022EGFREpidermal growth factor receptorErbB-1HER1TK inhibitorEGF receptorHN5breast cancerInhibitorinhibitorinhibit

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