2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Epigenetics Anti-infection
  3. HSP HDAC Fungal
  4. HDAC/HSP90-IN-3

HDAC/HSP90-IN-3 (化合物 J5) 是一种有效的选择性真菌 Hsp90 和 HDAC 双重抑制剂，其 IC50 值分别为 0.83 和 0.91 μM。HDAC/HSP90-IN-3 对耐唑白色念珠菌具有抗真菌活性。HDAC/HSP90-IN-3 可抑制重要毒力因子，下调耐药基因ERG11和CDR1。

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HDAC/HSP90-IN-3 Chemical Structure

HDAC/HSP90-IN-3 Chemical Structure

CAS No. : 2700035-54-5

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HDAC/HSP90-IN-3 相关抗体

Top Publications Citing Use of Products

查看 HSP 亚型特异性产品:

查看所有亚型
HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

查看 HDAC 亚型特异性产品:

查看所有亚型
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

HDAC/HSP90-IN-3 (compound J5) is a potent and selective fungal Hsp90 and HDAC dual inhibitor, with IC50 values of 0.83 and 0.91 μM, respectively. HDAC/HSP90-IN-3 shows antifungal activity against azole resistant C. albicans. HDAC/HSP90-IN-3 can suppress important virulence factors and down-regulate drug-resistant genes ERG11 and CDR1[1].

IC50 & Target

HSP90

0.83 μM (IC50, fungal Hsp90)

HDAC

0.91 μM (IC50, fungal HDACs)

human HDAC

3.0 μM (IC50, human HDACs)

HSP90

19.52 μM (IC50, human Hsp90)

体外研究
(In Vitro)

HDAC/HSP90-IN-3 (compound J5) significantly down-regulates the adherence-related genes (such as ALS3, HWP1, EAP1, BCR1), and down-regulates the expression of ERG11 and CDR1[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC/HSP90-IN-3 相关抗体:
分子量

511.57

Formula

C26H33N5O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

HDAC/HSP90-IN-3 相关分类

  • 摩尔计算器

  • 稀释计算器

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Keywords:

HDAC/HSP90-IN-32700035-54-5HSPHDACFungalHeat shock proteinsHistone deacetylaseslow toxicityantifungaldrug resistanceCandida albicanscandidiasisheat shock protein 90 (Hsp90)histone deacetylase (HDAC)invasive fungal infections (IFIs)Inhibitorinhibitorinhibit

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