KDM4B - lysine demethylase 4B Gene

中文名称：赖氨酸脱甲基酶 4B

种属: Homo sapiens

同用名: MRD65; JMJD2B; TDRD14B

基因 ID: 23030 | 基因类型: protein coding

关于 KDM4B

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:4,969,113-5,153,598 (from NCBI)

This gene has 12 transcripts (splice variants), 213 orthologues, 10 paralogues and is associated with 3 phenotypes. Ubiquitous expression in prostate (RPKM 5.2), thyroid (RPKM 5.0) and 25 other tissues.

功能概要

启用组蛋白 H3-甲基-赖氨酸-36 脱甲基酶活性和组蛋白 H3-甲基-赖氨酸-9 脱甲基酶活性。参与组蛋白 H3-K36 去甲基化和组蛋白 H3-K9 去甲基化。位于细胞质和核质中。与常染色体显性非综合征性智力障碍有关；乳腺癌;结直肠癌；恶性周围神经鞘瘤；和胃癌。多种疾病的生物标志物，包括斑秃；肺癌；髓母细胞瘤;前列腺癌;和胃癌。 [由基因组资源联盟提供，2022 年 4 月]

Enables histone H3-methyl-lysine-36 demethylase activity and histone H3-methyl-lysine-9 demethylase activity. Involved in histone H3-K36 demethylation and histone H3-K9 demethylation. Located in cytosol and nucleoplasm. Implicated in autosomal dominant non-syndromic intellectual disability; breast cancer; colorectal cancer; malignant peripheral nerve sheath tumor; and stomach Cancer. Biomarker of several diseases, including alopecia areata; lung cancer; medulloblastoma; prostate cancer; and stomach Cancer. [provided by Alliance of Genome Resources, Apr 2022]

KDM4B 基因产物(4)

mRNA	Protein	Name
NM_001370093.1	NP_001357022.1	lysine-specific demethylase 4B isoform 2
NM_001370094.1	NP_001357023.1	lysine-specific demethylase 4B isoform 3
NM_001411148.1	NP_001398077.1	lysine-specific demethylase 4B isoform 4
NM_015015.3	NP_055830.1	lysine-specific demethylase 4B isoform 1

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables histone H3K36 demethylase activity	IDA IDA: 通过直接分析推断	21914792	GOA
enables histone H3K9 demethylase activity	IMP IMP: 通过突变表型推断	28262558	GOA
enables histone H3K9me2/H3K9me3 demethylase activity	IDA IDA: 通过直接分析推断	21914792	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KDM4B 蛋白结构

JmjN

JmjC

PHD_2

zf-HC5HC2H_2

0
200
400
600
800
1000
1096 a.a.

蛋白主名

其他名称

lysine-specific demethylase 4B

[histone H3]-trimethyl-L-lysine(9) demethylase 4B

关联疾病

疾病名称

别名

Intellectual Developmental Disorder, Autosomal Dominant 65

MRD65

Mental Retardation, Autosomal Dominant 65

Non-Specific Syndromic Intellectual Disability

Complex Neurodevelopmental Disorder

Syndromic Intellectual Disability

Malignant Peripheral Nerve Sheath Tumor

Mpnst	Malignant Neurilemmoma
Neurofibrosarcoma	Malignant Neurofibroma
Malignant Schwannoma	Neurogenic Sarcoma
Schwannoma, Malignant	Malignant Neoplasm Of The Peripheral Nerve Sheath
Malignant Peripheral Nerve Sheath Tumors

Arboleda-Tham Syndrome

Kat6a Syndrome	Autosomal Dominant Intellectual Disability-Craniofacial Anomalies-Cardiac Defects Syndrome
ARTHS	Mrd32
Mental Retardation, Autosomal Dominant 32, Formerly	Mrd32, Formerly
Autosomal Dominant Mental Retardation 32	Autosomal Dominant Non-Syndromic Intellectual Disability 32
Arboleda-Tham

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Medulloblastoma

MDB	Cpnet
Localized Primitive Neuroectodermal Tumor	Classic Medulloblastoma
Medulloblastoma Predisposition Syndrome	Medulloblastoma, Somatic
Brain Medulloblastoma	Cns Pnet
Infratentorial Primitive Neuroectodermal Tumor	Neuroectodermal Tumors, Primitive
Medulloblastomas	Desmoplastic Medulloblastoma
Medulloblastoma, With Extensive Nodularity	Medulloblastoma Of Unspecified Site
Medullomyoblastoma Of Unspecified Site

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-104048	QC6352	Inhibitor	99.48%	否
HY-101799	NCGC00244536	Inhibitor	99.58%	否
HY-12725	ML324	Inhibitor	98.54%	否
HY-110154	NSC636819		98.9%	否
HY-RS07214	KDM4B Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	KDM4B	VGNC	VGNC:30528
Rattus norvegicus	KDM4B	RGD	RGD:1588576
Mus musculus	KDM4B	MGD	MGI:2442355
Canis familiaris	KDM4B	VGNC	VGNC:42325
Macaca mulatta	KDM4B	VGNC	VGNC:73930

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

KDM4B - lysine demethylase 4B Gene

关于 KDM4B

功能概要

KDM4B 基因产物(4)

KDM4B 蛋白结构

关联疾病

直系同源

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KDM4B - lysine demethylase 4B Gene

关于 KDM4B

功能概要

KDM4B 基因产物(4)

KDM4B 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z