1. Gene
  2. TTLL12 - tubulin tyrosine ligase like 12 Gene

TTLL12 - tubulin tyrosine ligase like 12 Gene

中文名称:微管蛋白酪氨酸连接酶 12

种属: Homo sapiens

同用名: dJ526I14.2

基因 ID: 23170 | 基因类型: protein coding

关于 TTLL12

Cytogenetic location: 22q13.2 Genomic coordinates (GRCh38): 22:43,166,622-43,187,134 (from NCBI)

This gene has 4 transcripts (splice variants), 196 orthologues and 12 paralogues. Ubiquitous expression in esophagus (RPKM 28.7), colon (RPKM 16.0) and 25 other tissues.

功能概要

启用 H4K20me3 修饰的组蛋白结合活性和微管蛋白结合活性。参与 I 型干扰素介导的信号通路的负调控和有丝分裂细胞周期的调控。位于细胞质中。 [由基因组资源联盟提供,2022 年 4 月]

Enables H4K20me3 modified histone binding activity and tubulin binding activity. Involved in negative regulation of type I interferon-mediated signaling pathway and regulation of mitotic cell cycle. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

TTLL12 基因产物(1)

mRNA Protein Name
NM_015140.4 NP_055955.1 tubulin--tyrosine ligase-like protein 12
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables H4K20me3 modified histone binding IDA
IDA: 通过直接分析推断
23251473 GOA
NOT enables histone H4K20 trimethyltransferase activity IDA
IDA: 通过直接分析推断
23251473 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
23251473 GOA
enables tubulin binding IDA
IDA: 通过直接分析推断
23251473 GOA
NOT enables tubulin-tyrosine ligase activity IDA
IDA: 通过直接分析推断
23251473 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of type I interferon-mediated signaling pathway IMP
IMP: 通过突变表型推断
28011935 GOA
involved in regulation of mitotic cell cycle IMP
IMP: 通过突变表型推断
23251473 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
28011935 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TTLL12 蛋白结构

TTL

TTL: Tubulin-tyrosine ligase family (348 - 639)

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  • 644 a.a.
蛋白主名 其他名称

tubulin--tyrosine ligase-like protein 12

inactive tubulin--tyrosine ligase-like protein 12

TTLL12 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TTLL12 Q14166 FAM222B Homo sapiens Q8WU58
Validated Y2H
32296183
种属内
TTLL12 Q14166 EEF1A1 Homo sapiens P68104
Y2H Array
32296183
种属内
TTLL12 Q14166 EEF1A1 Homo sapiens P68104
Y2H Prey Pooling
32296183
种属内
TTLL12 Q14166 EEF1A2 Homo sapiens Q05639
Y2H Array
32296183
种属内
TTLL12 Q14166 EEF1A2 Homo sapiens Q05639
Y2H Prey Pooling
32296183
种属内
TTLL12 Q14166 DNAJB1 Homo sapiens P25685
Y2H Array
32296183
种属内
TTLL12 Q14166 DNAJB1 Homo sapiens P25685
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Acute Closed-Angle Glaucoma

Acute Angle-Closure Glaucoma

Thrombocytopenia With Beta-Thalassemia, X-Linked

XLTT

Thrombocytopenia, Platelet Dysfunction, Hemolysis, And Imbalanced Globin Synthesis

Beta-Thalassemia-X-Linked Thrombocytopenia Syndrome

Gata1-Related X-Linked Cytopenia

X-Linked Thrombocytopenia With Beta-Thalassemia

Thrombocytopenia Platelet Dysfunction Hemolysis And Imbalanced Globin Synthesis

Orofaciodigital Syndrome Viii

Edwards Syndrome

Trisomy 18

Complete Trisomy 18 Syndrome

OFD8

Orofaciodigital Syndrome 8

Trisomy 18 Syndrome

Oral-Facial-Digital Syndrome With Hypoplastic Epiglottis

E3 Trisomy

Oral-Facial-Digital Syndrome Type 8

Orofaciodigital Syndrome Type 8

Ofds Viii

Oral-Facial-Digital Syndrome, Type Viii

Ofd Syndrome 8

Ofds 8

Oral Facial Digital Syndrome 8

Oral Facial Digital Syndrome Type 8

18 Trisomy

Chromosome 18 Trisomy

Trisomy 16-18

Trisomy E

Trisomy E Syndrome

Chromosome 18 Duplication

Oral-Facial-Digital Syndrome, Edwards Type

Orofaciodigital Syndrome, Edwards Type

Chromosome 18, Trisomy

Cleft Lip/Palate With Abnormal Thumbs And Microcephaly

Trisomy 18 Chromosome

Abnormal Autosomes 18

Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus TTLL12 MGD MGI:3039573
Canis familiaris TTLL12 VGNC VGNC:47975
Macaca mulatta TTLL12 VGNC VGNC:79757
Felis catus TTLL12 VGNC VGNC:66687
Bos taurus TTLL12 VGNC VGNC:36491
Rattus norvegicus TTLL12 RGD RGD:1305319