Ntrk2 - neurotrophic receptor tyrosine kinase 2 Gene

中文名称：神经营养 受体酪氨酸激酶 2

种属: Rattus norvegicus

同用名: Tkrb; trkB; TRKB1; trk-B; RATTRKB1

关于 Ntrk2

功能概要

该基因编码的蛋白可启动多种功能，包括脑源性神经营养因子结合活性；脑源性神经营养因子激活受体活性；和蛋白质同二聚化活性。参与多个过程，包括脑源性神经营养因子受体信号通路；细胞通讯的正向调节；和神经元投射发育的调节。在糖皮质激素受体信号通路的正调节上游或正调节内起作用。位于多个细胞成分中，包括远端轴突；核周;和突触后密度。是质膜的组成部分。活跃于谷氨酸能突触和突触后。用于研究青光眼。多种疾病的生物标志物，包括注意力缺陷多动障碍；结肠炎;精神抑郁症；创伤后应激障碍；和颞叶癫痫。该基因的人类直系同源物与阿尔茨海默病有关；自闭症；发育性和癫痫性脑病 58；严重抑郁症;和病态肥胖。与人类 NTRK2（神经营养受体酪氨酸激酶 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including brain-derived neurotrophic factor binding activity; brain-derived neurotrophic factor-activated receptor activity; and protein homodimerization activity. Involved in several processes, including brain-derived neurotrophic factor receptor signaling pathway; positive regulation of cell communication; and regulation of neuron projection development. Acts upstream of or within positive regulation of Glucocorticoid Receptor signaling pathway. Located in several cellular components, including distal axon; perikaryon; and postsynaptic density. Is integral component of plasma membrane. Is active in glutamatergic synapse and postsynapse. Used to study glaucoma. Biomarker of several diseases, including attention deficit hyperactivity disorder; colitis; mental depression; post-traumatic stress disorder; and temporal lobe epilepsy. Human ortholog(s) of this gene implicated in Alzheimer's disease; autistic disorder; developmental and epileptic encephalopathy 58; major depressive disorder; and morbid obesity. Orthologous to human NTRK2 (neurotrophic receptor tyrosine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]