Ntrk2 - neurotrophic tyrosine kinase, receptor, type 2 Gene

中文名称：神经营养性酪氨酸激酶，受体，2 型

种属: Mus musculus

同用名: Tkrb; trkB; trk-B; GP145-TrkB/GP95-TrkB

关于 Ntrk2

功能概要

该基因编码的蛋白可启动脑源性神经营养因子结合活性和脑源性神经营养因子激活受体活性。参与多个过程，包括脑源性神经营养因子受体信号通路；神经系统发育；和跨突触信号，调节突触传递。作用于几个过程的上游或内部，包括神经发生；神经元动作电位传播；和肽基丝氨酸磷酸化的正调节。位于多种细胞成分中，包括早期内体；突触后密度；和突触后膜。以多种结构表达，包括消化系统；心血管系统;未来的大脑；泌尿生殖系统；和神经系统。该基因的人类直系同源物与阿尔茨海默病有关；自闭症；发育性和癫痫性脑病 58；严重抑郁症;和病态肥胖。与人类 NTRK2（神经营养受体酪氨酸激酶 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables brain-derived neurotrophic factor binding activity and brain-derived neurotrophic factor-activated receptor activity. Involved in several processes, including brain-derived neurotrophic factor receptor signaling pathway; nervous system development; and trans-synaptic signaling, modulating synaptic transmission. Acts upstream of or within several processes, including neurogenesis; neuronal action potential propagation; and positive regulation of peptidyl-serine phosphorylation. Located in several cellular components, including early endosome; postsynaptic density; and postsynaptic membrane. Is expressed in several structures, including alimentary system; cardiovascular system; future brain; genitourinary system; and nervous system. Human ortholog(s) of this gene implicated in Alzheimer's disease; autistic disorder; developmental and epileptic encephalopathy 58; major depressive disorder; and morbid obesity. Orthologous to human NTRK2 (neurotrophic receptor tyrosine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]