1. Gene
  2. Avpr1a - arginine vasopressin receptor 1A Gene

Avpr1a - arginine vasopressin receptor 1A Gene

中文名称:精氨酸加压素受体 1A

种属: Rattus norvegicus

同用名: V1a; AVPR; V1aR

基因 ID: 25107 | 基因类型: protein coding

关于 Avpr1a

Primary_assembly 7: 58,114,284-58,122,215 forward strand.mRatBN7.2:CM026980.1

This gene has 2 transcripts (splice variants), 264 orthologues, 16 paralogues and is associated with 13 phenotypes. Biased expression in Liver (RPKM 395.2), Kidney (RPKM 31.7) and 2 other tissues.

功能概要

该基因编码精氨酸加压素的受体,精氨酸加压素是一种神经垂体激素,参与利尿抑制、平滑肌收缩、肝糖原分解刺激和垂体促肾上腺皮质激素释放的调节。该受体代表三种 G 蛋白偶联的精氨酸加压素受体之一,其通过血管和肝组织中的磷脂酰肌醇-钙第二信使系统发挥作用。 [RefSeq 提供,2008 年 7 月]

This gene encodes a receptor for arginine vasopressin, a neurohypophyseal hormone involved in diuresis inhibition, smooth muscle contraction, liver glycogenolysis stimulation and regulation of adrenocorticotropic hormone release from the pituitary. This receptor represents one of three G protein-coupled arginine vasopressin receptors which functions through a phosphotidylinositol-calcium second messenger system in vascular and hepatic tissues. [provided by RefSeq, Jul 2008]

Avpr1a 基因产物(1)

mRNA Protein Name
NM_053019.2 NP_444178.2 vasopressin V1a receptor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables V1A vasopressin receptor binding IDA
IDA: 通过直接分析推断
1560825 RGD
enables peptide hormone binding IMP
IMP: 通过突变表型推断
12942143 RGD
enables vasopressin receptor activity IDA
IDA: 通过直接分析推断
19560475 RGD
enables vasopressin receptor activity IMP
IMP: 通过突变表型推断
12942143 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in calcium-mediated signaling IMP
IMP: 通过突变表型推断
12088846 RGD
involved in cellular response to water deprivation IEP
IEP: 通过表达模式推断
11796498 RGD
involved in grooming behavior IMP
IMP: 通过突变表型推断
18640147 RGD
involved in maternal aggressive behavior IMP
IMP: 通过突变表型推断
18640147 RGD
involved in maternal behavior IMP
IMP: 通过突变表型推断
18640147 RGD
involved in myotube differentiation IEP
IEP: 通过表达模式推断
18021262 RGD
involved in negative regulation of female receptivity IMP
IMP: 通过突变表型推断
16488546 RGD
involved in negative regulation of transmission of nerve impulse IMP
IMP: 通过突变表型推断
16304841 RGD
involved in positive regulation of blood pressure IMP
IMP: 通过突变表型推断
18339407 RGD
involved in positive regulation of cell growth IMP
IMP: 通过突变表型推断
17395547 RGD
involved in positive regulation of cell population proliferation IMP
IMP: 通过突变表型推断
17395547 RGD
involved in positive regulation of cellular pH reduction IMP
IMP: 通过突变表型推断
17762181 RGD
involved in positive regulation of cytosolic calcium ion concentration IMP
IMP: 通过突变表型推断
12088846 RGD
involved in positive regulation of glutamate secretion IMP
IMP: 通过突变表型推断
17877638 RGD
involved in positive regulation of heart rate IMP
IMP: 通过突变表型推断
18339407 RGD
involved in positive regulation of prostaglandin biosynthetic process IMP
IMP: 通过突变表型推断
17254553 RGD
involved in positive regulation of systemic arterial blood pressure IMP
IMP: 通过突变表型推断
17350115 RGD
involved in positive regulation of vasoconstriction IMP
IMP: 通过突变表型推断
17428891 RGD
involved in response to corticosterone IEP
IEP: 通过表达模式推断
15475662 RGD
involved in social behavior IDA
IDA: 通过直接分析推断
12887422 RGD
involved in social behavior IEP
IEP: 通过表达模式推断
16154572 RGD
involved in sperm ejaculation IMP
IMP: 通过突变表型推断
18552879 RGD
involved in telencephalon development IEP
IEP: 通过表达模式推断
11021977 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Avpr1a 蛋白结构

7tmA_V1aR

7tmA_V1aR: cd15385 (51 - 364)

7tmA_V1aR

7tmA_V1aR: cd15385 (52 - 78)

7tmA_V1aR

7tmA_V1aR: cd15385 (85 - 112)

7tmA_V1aR

7tmA_V1aR: cd15385 (123 - 153)

7tmA_V1aR

7tmA_V1aR: cd15385 (165 - 186)

7tmA_V1aR

7tmA_V1aR: cd15385 (214 - 243)

7tmA_V1aR

7tmA_V1aR: cd15385 (289 - 319)

7tmA_V1aR

7tmA_V1aR: cd15385 (332 - 357)

DUF1856

DUF1856: pfam08983 (377 - 423)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 424 a.a.
蛋白主名 其他名称

vasopressin V1a receptor

antidiuretic hormone receptor 1a

arginine vasopressin receptor V1a

vascular/hepatic-type arginine vasopressin receptor

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Avpr1a NCBI NCBI:552