AVPR1A - arginine vasopressin receptor 1A Gene

中文名称：精氨酸加压素受体 1A

种属: Homo sapiens

同用名: V1aR; AVPR1; AVPR V1a

基因 ID: 552 | 基因类型: protein coding

关于 AVPR1A

Cytogenetic location: 12q14.2 Genomic coordinates (GRCh38): 12:63,142,759-63,151,201 (from NCBI)

This gene has 2 transcripts (splice variants), 264 orthologues and 16 paralogues. Biased expression in adrenal (RPKM 29.7), endometrium (RPKM 8.7) and 7 other tissues.

功能概要

由该基因编码的蛋白质充当精氨酸加压素的受体。该受体属于 G 蛋白偶联受体亚家族，其中包括 AVPR1B、V2R 和 OXT 受体。其活性由刺激磷脂酰肌醇-钙第二信使系统的 G 蛋白介导。该受体介导细胞收缩和增殖、血小板聚集、凝血因子释放和糖原分解。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1B, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor mediates cell contraction and proliferation, platelet aggregation, release of coagulation factor and glycogenolysis. [provided by RefSeq, Jul 2008]

AVPR1A 基因产物(1)

mRNA	Protein	Name
NM_000706.5	NP_000697.1	vasopressin V1a receptor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	18402937	GOA
enables vasopressin receptor activity	IDA IDA: 通过直接分析推断	9322919	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of cell population proliferation	IDA IDA: 通过直接分析推断	9322919	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in endocytic vesicle	IDA IDA: 通过直接分析推断	14757828	GOA
located in endosome	IDA IDA: 通过直接分析推断	14757828	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	14757828	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

AVPR1A 蛋白结构

7tm_1

DUF1856

0
100
200
300
418 a.a.

蛋白主名

其他名称

vasopressin V1a receptor

SCCL vasopressin subtype 1a receptor	V1-vascular vasopressin receptor AVPR1A
V1a vasopressin receptor	antidiuretic hormone receptor 1A
vascular/hepatic-type arginine vasopressin receptor

AVPR1A 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	AVPR1A	P37288	ACKR3	Homo sapiens	P25106	Anti Bait CoIP	29386406
种属内	AVPR1A	P37288	ACKR3	Homo sapiens	P25106	PLA	29386406

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Personality Disorder

Personality Disorders	Character Disorder
Personality	Specific Personality Disorders
Enduring Personality Change After Psychiatric Illness

Diabetes Insipidus

Episodic Pain Syndrome, Familial, 1

FEPS1	Familial Episodic Pain Syndrome With Predominantly Upper Body Involvement
Familial Episodic Pain Syndrome 1

Voyeurism

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Asperger Syndrome

Asperger Disorder

Panic Disorder

Panic Anxiety Syndrome	Panic
Panic Disorder 1	Episodic Paroxysmal Anxiety Disorder

X-Linked Nephrogenic Diabetes Insipidus

Nephrogenic Diabetes Insipidus Type 1

Doid:0081060

Nephrogenic Diabetes Insipidus

Vasopressin-Resistant Diabetes Insipidus	Diabetes Insipidus, Nephrogenic
Diabetes Insipidus Nephrogenic	Congenital Nephrogenic Diabetes Insipidus
Adh Resistant Diabetes Insipidus	Diabetes Insipidus Nephrogenic X-Linked
Diabetes Insipidus Nephrogenic Type 1	Adh-Resistant Diabetes Insipidus
Diabetes Insipidus Renalis	Ndi
Renal Diabetes Insipidus	Familial Nephrogenic Diabetes
Antidiuretic-Hormone-Resistant Diabetes Insipidus	Adiuretin-Resistant Diabetes Insipidus
Ndi - [Nephrogenic Diabetes Insipidus]	Diabetes Tenuifluus
Adh - [Antidiuretic-Hormone] Resistant Diabetes Insipidus	Hereditary Nephrogenic Diabetes Insipidus
Familial Nephrogenic Diabetes Insipidus	Primary Nephrogenic Diabetes Insipidus

Borderline Personality Disorder

Diabetes Insipidus, Neurohypophyseal

Neurohypophyseal Diabetes Insipidus	Central Diabetes Insipidus
Cdi	Pituitary Diabetes Insipidus
Vasopressin Defective Diabetes Insipidus	Vasopressin Deficiency
Diabetes Insipidus, Neurogenic	Diabetes Insipidus, Primary Central
Diabetes Insipidus, Cranial Type	Diabetes Insipidus Secondary To Vasopressin Deficiency
Diabetes Insipidus, Central	Diabetes Insipidus, Pituitary
NDI	Diabetes Insipidus Cranial Type
Neurogenic Diabetes Insipidus	Primary Central Diabetes Insipidus

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Amusia

Receptive Amusia

Nephrogenic Syndrome Of Inappropriate Antidiuresis

NSIAD

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

Pervasive Developmental Disorder

Pervasive Development Disorder	Pervasive Developmental Disorders
Pervasive Child Development Disorders	Autistic Behavior
Autism Spectrum Disorders

Hepatorenal Syndrome

Hepato-Renal Syndrome	Hepatorenal Failure
Hrf - [Hepatorenal Failure]	Hepatorenal Degeneration
Hepatic Renal Syndrome	Hepatic Renal Failure
Renal Hepatic Failure	Urohepatic Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	是否罕见病
HY-P0049A	Argipressin diacetate		/	否

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P4990	Pro8-Oxytocin	Activator	/	否
HY-P4990A	Pro8-Oxytocin TFA	Activator	/	否
HY-RS01281	AVPR1A Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS01282	Avpr1a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS01283	Avpr1a Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	AVPR1A	MGD	MGI:1859216
Canis familiaris	AVPR1A	VGNC	VGNC:38318
Rattus norvegicus	AVPR1A	RGD	RGD:2185
Felis catus	AVPR1A	VGNC	VGNC:68838
Macaca mulatta	AVPR1A	VGNC	VGNC:70197
Bos taurus	AVPR1A	VGNC	VGNC:26358

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

AVPR1A - arginine vasopressin receptor 1A Gene

关于 AVPR1A

功能概要

AVPR1A 基因产物(1)

AVPR1A 蛋白结构

AVPR1A 蛋白互作信息

关联疾病

直系同源

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AVPR1A - arginine vasopressin receptor 1A Gene

关于 AVPR1A

功能概要

AVPR1A 基因产物(1)

AVPR1A 蛋白结构

AVPR1A 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z