2. Gene
  3. Pgr - progesterone receptor Gene

Pgr - progesterone receptor Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：孕激素受体

种属: Rattus norvegicus

基因 ID: 25154 | 基因类型: protein coding

关于 Pgr

Primary_assembly 8: 6,072,673-6,131,344 forward strand.mRatBN7.2:CM026981.1

This gene has 1 transcript (splice variant), 193 orthologues, 8 paralogues and is associated with 19 phenotypes. Biased expression in Uterus (RPKM 178.1), Brain (RPKM 36.9) and 1 other tissue.

功能概要

该基因编码的蛋白可启动多种功能，包括序列特异性 DNA 结合活性；类固醇结合活性；和类固醇激素受体活性。参与多个过程，包括细胞对促性腺激素刺激的反应；动情周期；和转录调控，DNA 模板化。位于多个细胞成分中，包括轴突末端；树突棘;和周核体。子宫内膜异位症和多囊卵巢综合征的生物标志物。该基因与子宫内膜异位症相关的人类直向同源基因；高催乳素血症;和肥胖。与人类 PGR（黄体酮受体）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including sequence-specific DNA binding activity; steroid binding activity; and steroid hormone receptor activity. Involved in several processes, including cellular response to gonadotropin stimulus; estrous cycle; and regulation of transcription, DNA-templated. Located in several cellular components, including axon terminus; dendritic spine; and perikaryon. Biomarker of endometriosis and polycystic ovary syndrome. Human ortholog(s) of this gene implicated in endometriosis; hyperprolactinemia; and obesity. Orthologous to human PGR (Progesterone Receptor). [provided by Alliance of Genome Resources, Apr 2022]

Pgr 基因产物(1)

mRNA Protein Name
NM_022847.2 NP_074038.2 progesterone receptor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables hormone binding IMP
IMP: 通过突变表型推断
11113338 RGD
enables nuclear steroid receptor activity IMP
IMP: 通过突变表型推断
11113338 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
16020483 RGD
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
17109827 RGD
enables steroid binding IMP
IMP: 通过突变表型推断
11113338 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to estrogen stimulus IEP
IEP: 通过表达模式推断
17272396 RGD
involved in cellular response to follicle-stimulating hormone stimulus IEP
IEP: 通过表达模式推断
8344215 RGD
involved in cellular response to gonadotropin stimulus IEP
IEP: 通过表达模式推断
8344215 RGD
involved in cellular response to luteinizing hormone stimulus IEP
IEP: 通过表达模式推断
8344215 RGD
involved in cellular response to wortmannin IEP
IEP: 通过表达模式推断
17272396 RGD
involved in diterpenoid metabolic process IEP
IEP: 通过表达模式推断
8344215 RGD
involved in estrous cycle IEP
IEP: 通过表达模式推断
16461543 RGD
involved in female mating behavior IMP
IMP: 通过突变表型推断
19094083 RGD
involved in luteinization IEP
IEP: 通过表达模式推断
8344215 RGD
involved in negative regulation of DNA-templated transcription IEP
IEP: 通过表达模式推断
12457039 RGD
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
22778216 RGD
involved in negative regulation of granulosa cell apoptotic process IMP
IMP: 通过突变表型推断
19208546 RGD
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
8344215 RGD
involved in positive regulation of cell population proliferation IDA
IDA: 通过直接分析推断
16020483 RGD
involved in positive regulation of smooth muscle cell migration IMP
IMP: 通过突变表型推断
21440892 RGD
involved in response to cocaine IDA
IDA: 通过直接分析推断
17109827 RGD
involved in response to estrogen IEP
IEP: 通过表达模式推断
22147012 RGD
involved in response to progesterone IEP
IEP: 通过表达模式推断
22147012 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
18720413 RGD
located in axon terminus IDA
IDA: 通过直接分析推断
18720413 RGD
located in dendrite IDA
IDA: 通过直接分析推断
18720413 RGD
located in dendritic spine IDA
IDA: 通过直接分析推断
18720413 RGD
located in perikaryon IDA
IDA: 通过直接分析推断
18720413 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Pgr 蛋白结构

Prog_receptor

Prog_receptor: pfam02161 (0 - 556)

NR_DBD_GR_PR

NR_DBD_GR_PR: cd07172 (555 - 632)

NR_LBD_PR

NR_LBD_PR: cd07074 (678 - 925)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 926 a.a.
蛋白主名 其他名称

progesterone receptor

PR

nuclear receptor subfamily 3 group C member 3

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10396 PGR Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10397 Pgr Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10398 Pgr Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pgr NCBI NCBI:5241
Mus musculus Pgr NCBI NCBI:18667
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