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  3. Prkcz - protein kinase C, zeta Gene

Prkcz - protein kinase C, zeta Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：蛋白激酶 C，zeta

种属: Rattus norvegicus

同用名: Pkcz; r14-3-3; 14-3-3-zetaisoform

基因 ID: 25522 | 基因类型: protein coding

关于 Prkcz

Primary_assembly 5: 165,819,466-165,930,367 reverse strand.mRatBN7.2:CM026978.1

This gene has 1 transcript (splice variant), 205 orthologues, 9 paralogues and is associated with 23 phenotypes. Biased expression in Brain (RPKM 18.1), Kidney (RPKM 59.9) and 7 other tissues.

功能概要

该基因编码的蛋白可启动多种功能，包括 14-3-3 蛋白结合活性；酶结合活性；和蛋白激酶 C 活性。参与多个过程，包括磷脂酶 D 活性的激活；激活蛋白激酶 B 活性；和细胞通讯的积极调节。位于几种细胞成分中，包括膜筏；细胞质的核周区；和应力纤维。活跃于 Schaffer 侧支 - CA1 突触；谷氨酸能突触；和突触后密度。用于研究高血糖症。 2 型糖尿病的生物标志物。与人 PRKCZ（蛋白激酶 C zeta）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including 14-3-3 protein binding activity; Enzyme binding activity; and protein kinase C activity. Involved in several processes, including activation of Phospholipase D activity; activation of protein kinase B activity; and positive regulation of cell communication. Located in several cellular components, including membrane raft; perinuclear region of cytoplasm; and stress fiber. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density. Used to study hyperglycemia. Biomarker of type 2 diabetes mellitus. Orthologous to human PRKCZ (protein kinase C zeta). [provided by Alliance of Genome Resources, Apr 2022]

Prkcz 基因产物(1)

mRNA Protein Name
NM_022507.1 NP_071952.1 protein kinase C zeta type
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 14-3-3 protein binding IPI
IPI: 通过物理相互作用推断
17308302 RGD
enables phospholipase binding IPI
IPI: 通过物理相互作用推断
16113073 RGD
enables potassium channel regulator activity IMP
IMP: 通过突变表型推断
15062979 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
9514928 RGD
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
9768361 RGD
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
12130632 RGD
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
10477520 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in activation of phospholipase D activity IMP
IMP: 通过突变表型推断
16113073 RGD
involved in activation of protein kinase B activity IMP
IMP: 通过突变表型推断
15007074 RGD
involved in cell migration IMP
IMP: 通过突变表型推断
19885391 RGD
involved in cell surface receptor signaling pathway IMP
IMP: 通过突变表型推断
15007074 RGD
involved in cellular response to insulin stimulus IMP
IMP: 通过突变表型推断
16525020 RGD
involved in establishment of cell polarity IMP
IMP: 通过突变表型推断
11525734 RGD
involved in intracellular signal transduction IDA
IDA: 通过直接分析推断
12130632 RGD
involved in long-term memory IMP
IMP: 通过突变表型推断
17702943 RGD
involved in long-term synaptic potentiation IMP
IMP: 通过突变表型推断
11914719 RGD
involved in membrane depolarization IMP
IMP: 通过突变表型推断
15381257 RGD
involved in membrane hyperpolarization IMP
IMP: 通过突变表型推断
15062979 RGD
involved in negative regulation of apoptotic process IDA
IDA: 通过直接分析推断
17346242 RGD
involved in negative regulation of hydrolase activity IDA
IDA: 通过直接分析推断
17346242 RGD
involved in peptidyl-serine phosphorylation IDA
IDA: 通过直接分析推断
12061804 RGD
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: 通过突变表型推断
8557035 RGD
involved in positive regulation of NF-kappaB transcription factor activity IMP
IMP: 通过突变表型推断
8557035 RGD
involved in positive regulation of cell population proliferation IMP
IMP: 通过突变表型推断
16679391 RGD
involved in positive regulation of cell-matrix adhesion IMP
IMP: 通过突变表型推断
16113073 RGD
involved in positive regulation of excitatory postsynaptic potential IDA
IDA: 通过直接分析推断
11914719 RGD
involved in positive regulation of insulin receptor signaling pathway IMP
IMP: 通过突变表型推断
9374484 RGD
involved in positive regulation of protein transport IMP
IMP: 通过突变表型推断
15007074 RGD
involved in positive regulation of synaptic transmission IMP
IMP: 通过突变表型推断
15728837 RGD
involved in protein kinase C signaling IMP
IMP: 通过突变表型推断
20570724 RGD
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
10477520 RGD
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IDA
IDA: 通过直接分析推断
18667614 RGD
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IMP
IMP: 通过突变表型推断
18667614 RGD
involved in vesicle transport along microtubule IMP
IMP: 通过突变表型推断
16734659 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in Schaffer collateral - CA1 synapse IDA
IDA: 通过直接分析推断
18667614 RGD
is active in Schaffer collateral - CA1 synapse IMP
IMP: 通过突变表型推断
18667614 RGD
located in cell leading edge IDA
IDA: 通过直接分析推断
19885391 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
18667614 RGD
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
18667614 RGD
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
16525020 RGD
located in plasma membrane IDA
IDA: 通过直接分析推断
11525734 RGD
is active in postsynaptic density IDA
IDA: 通过直接分析推断
24298142 RGD
located in stress fiber IDA
IDA: 通过直接分析推断
16525020 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Prkcz 蛋白结构

PB1_aPKC

PB1_aPKC: cd06404 (15 - 97)

C1_aPKC_zeta

C1_aPKC_zeta: cd21095 (128 - 182)

STKc_aPKC_zeta

STKc_aPKC_zeta: cd05617 (248 - 604)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 605 a.a.
蛋白主名 其他名称

protein kinase C zeta type

nPKC-zeta

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11141 PRKCZ Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS11142 Prkcz Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS11143 Prkcz Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Prkcz NCBI NCBI:5590
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