GALNT1 - polypeptide N-acetylgalactosaminyltransferase 1 Gene

中文名称：多肽 N-乙酰半乳糖氨基转移酶 1

种属: Homo sapiens

同用名: GALNAC-T1

关于 GALNT1

功能概要

该基因编码 UDP-N-乙酰基-α-D-半乳糖胺：多肽 N-乙酰半乳糖胺基转移酶 (GalNAc-T) 酶家族的成员。 GalNAc-Ts 通过催化 GalNAc 转移到靶蛋白上的丝氨酸和苏氨酸残基，在高尔基体中启动粘蛋白型 O-连接糖基化。它们的特征在于 N 末端跨膜结构域、茎区、含有 GT1 基序和 Gal/GalNAc 转移酶基序的腔催化结构域，以及 C 末端蓖麻蛋白/凝集素样结构域。 GalNAc-T 具有不同但重叠的底物特异性和表达模式。文献中已经描述了源自该基因的转录变体，这些变体利用替代的 polyA 信号。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T) family of Enzymes. GalNAc-Ts initiate mucin-type O-linked glycosylation in the Golgi apparatus by catalyzing the transfer of GalNAc to serine and threonine residues on target proteins. They are characterized by an N-terminal transmembrane domain, a stem region, a lumenal catalytic domain containing a GT1 motif and Gal/GalNAc transferase motif, and a C-terminal ricin/lectin-like domain. GalNAc-Ts have different, but overlapping, substrate specificities and patterns of expression. Transcript variants derived from this gene that utilize alternative polyA signals have been described in the literature. [provided by RefSeq, Jul 2008]