2. Metabolic Enzyme/Protease Stem Cell/Wnt
  3. Endogenous Metabolite β-catenin Wnt
  4. N-Acetylgalactosaminyltransferase 1

N-Acetylgalactosaminyltransferase 1  (Synonyms: GALNT1)

目录号: HY-E70290
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摩尔计算器

N-Acetylgalactosaminyltransferase 1 (GALNT1) 是糖基化转移酶，通过将 UDP-GalNAc 中的 α-GalNAc 转移到蛋白质中的丝氨酸 (Ser) 或苏氨酸 (Thr) 残基上，从而启动粘蛋白型 O-糖基化。N-Acetylgalactosaminyltransferase 1 在胃癌中过表达能通过促进 CD44 的异常 O-糖基化，从而激活 Wnt/β-catenin 信号通路，并调控胃癌细胞的恶性行为。N-Acetylgalactosaminyltransferase 1 通过修改各种糖蛋白 (如粘蛋白 (MUC1)、骨桥蛋白 (OPN)、基质金属蛋白酶-14 (MMP14) 和整合素 α3) 的 O-糖基化，在癌症生长和转移中发挥着至关重要的作用。

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N-Acetylgalactosaminyltransferase 1 Chemical Structure

N-Acetylgalactosaminyltransferase 1 Chemical Structure

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N-Acetylgalactosaminyltransferase 1 相关抗体

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  • 生物活性

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生物活性

N-Acetylgalactosaminyltransferase 1 (GALNT1) is a glycosyltransferase that initiates mucin-type O-glycosylation by transferring α-GalNAc from UDP-GalNAc to serine (Ser) or threonine (Thr) residues in proteins. Overexpression of N-Acetylgalactosaminyltransferase 1 in gastric cancer can promote abnormal O-glycosylation of CD44, thereby activating the Wnt/β-catenin signaling pathway and regulating the malignant behavior of gastric cancer cells. Additionally, N-Acetylgalactosaminyltransferase 1 plays a crucial role in cancer growth and metastasis by modifying the O-glycosylation of various glycoproteins, such as mucin (MUC1), osteopontin (OPN), matrix metalloproteinase-14 (MMP14), and integrin α3[1].

中文名称

N-乙酰半乳糖氨基转移酶1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

N-Acetylgalactosaminyltransferase 1 相关分类

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Keywords:

N-Acetylgalactosaminyltransferase 1GALNT1N-乙酰半乳糖氨基转移酶1GALNT 1GALNT-1Endogenous Metaboliteβ-cateninWntBeta cateninO-glycosylationgastric cancerInhibitorinhibitorinhibit

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