2. Gene
  3. RPS6KC1 - ribosomal protein S6 kinase C1 Gene

RPS6KC1 - ribosomal protein S6 kinase C1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：核糖体蛋白 S6 激酶 C1

种属: Homo sapiens

同用名: RSKL1; RPK118; S6PKh1; humS6PKh1; S6K-delta-1

基因 ID: 26750 | 基因类型: protein coding

关于 RPS6KC1

Cytogenetic location: 1q32.3 Genomic coordinates (GRCh38): 1:213,051,241-213,862,735 (from NCBI)

This gene has 9 transcripts (splice variants), 207 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 12.3), brain (RPKM 7.8) and 25 other tissues.

功能概要

鞘氨醇激酶催化鞘氨醇 1 磷酸盐 (一种脂质细胞信使) 的形成。由该基因编码的蛋白质可以与鞘氨醇激酶和磷脂酰肌醇 3-磷酸结合，表明在鞘氨醇 1 磷酸信号传导中起作用。编码的蛋白质还可以与过氧化物酶 3 结合，并可能有助于将其转运至线粒体。[RefSeq 提供，2017 年 3 月]

Sphingosine kinase catalyzes the formation of sphingosine 1 phosphate, a lipid cellular messenger. The protein encoded by this gene can bind to sphingosine kinase and to phosphatidylinositol 3-phosphate, suggesting a role in sphingosine 1 phophate signaling. The encoded protein can also bind to peroxiredoxin-3 and may help transport it to mitochondria. [provided by RefSeq, Mar 2017]

RPS6KC1 基因产物(31)

mRNA Protein Name
NM_001136138.4 NP_001129610.1 ribosomal protein S6 kinase delta-1 isoform b
NM_001287218.3 NP_001274147.1 ribosomal protein S6 kinase delta-1 isoform c
NM_001287219.3 NP_001274148.1 ribosomal protein S6 kinase delta-1 isoform c
NM_001287220.3 NP_001274149.1 ribosomal protein S6 kinase delta-1 isoform d
NM_001287221.3 NP_001274150.1 ribosomal protein S6 kinase delta-1 isoform e
NM_001349646.2 NP_001336575.1 ribosomal protein S6 kinase delta-1 isoform f
NM_001349647.2 NP_001336576.1 ribosomal protein S6 kinase delta-1 isoform g
NM_001349648.2 NP_001336577.1 ribosomal protein S6 kinase delta-1 isoform e
NM_001349649.2 NP_001336578.1 ribosomal protein S6 kinase delta-1 isoform e
NM_001349650.2 NP_001336579.1 ribosomal protein S6 kinase delta-1 isoform e
NM_001349651.2 NP_001336580.1 ribosomal protein S6 kinase delta-1 isoform e
NM_001349652.2 NP_001336581.1 ribosomal protein S6 kinase delta-1 isoform e
NM_001349653.2 NP_001336582.1 ribosomal protein S6 kinase delta-1 isoform e
NM_001349654.2 NP_001336583.1 ribosomal protein S6 kinase delta-1 isoform c
NM_001349657.2 NP_001336586.1 ribosomal protein S6 kinase delta-1 isoform h
NM_001349658.2 NP_001336587.1 ribosomal protein S6 kinase delta-1 isoform h
NM_001349659.2 NP_001336588.1 ribosomal protein S6 kinase delta-1 isoform i
NM_001349660.2 NP_001336589.1 ribosomal protein S6 kinase delta-1 isoform i
NM_001349661.2 NP_001336590.1 ribosomal protein S6 kinase delta-1 isoform i
NM_001349662.2 NP_001336591.1 ribosomal protein S6 kinase delta-1 isoform i
NM_001349663.2 NP_001336592.1 ribosomal protein S6 kinase delta-1 isoform d
NM_001349664.2 NP_001336593.1 ribosomal protein S6 kinase delta-1 isoform d
NM_001349665.2 NP_001336594.1 ribosomal protein S6 kinase delta-1 isoform d
NM_001349666.2 NP_001336595.1 ribosomal protein S6 kinase delta-1 isoform d
NM_001349667.2 NP_001336596.1 ribosomal protein S6 kinase delta-1 isoform d
NM_001349668.2 NP_001336597.1 ribosomal protein S6 kinase delta-1 isoform d
NM_001349669.2 NP_001336598.1 ribosomal protein S6 kinase delta-1 isoform d
NM_001349670.2 NP_001336599.1 ribosomal protein S6 kinase delta-1 isoform d
NM_001349671.2 NP_001336600.1 ribosomal protein S6 kinase delta-1 isoform d
NM_001349672.2 NP_001336601.1 ribosomal protein S6 kinase delta-1 isoform j
NM_012424.6 NP_036556.2 ribosomal protein S6 kinase delta-1 isoform a
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15750338 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in early endosome IDA
IDA: 通过直接分析推断
15750338 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RPS6KC1 蛋白结构

PX

PX: PX domain (16 - 126)

MIT

MIT: MIT (microtubule interacting and transport) domain (239 - 305)

Pkinase

Pkinase: Protein kinase domain (881 - 1056)

  • 0
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  • 1066 a.a.
蛋白主名 其他名称

ribosomal protein S6 kinase delta-1

52 kDa ribosomal protein S6 kinase

RPS6KC1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra RPS6KC1 Q96S38 VDR Homo sapiens P11473-2
Y2H Prey Pooling
32296183
Intra RPS6KC1 Q96S38 VDR Homo sapiens P11473-2
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Periventricular Leukomalacia

Leukomalacia, Periventricular

Pvl

Leukomalacia Periventricular
Hypotonia
Charcot-Marie-Tooth Disease, Axonal, Type 2n

Charcot-Marie-Tooth Disease Axonal Type 2n

CMT2N

Autosomal Dominant Charcot-Marie-Tooth Disease Type 2n

Charcot-Marie-Tooth Neuropathy Axonal Type 2n

Charcot-Marie-Tooth Neuropathy, Axonal, Type 2n

Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2n

Autosomal Dominant Axonal Charcot-Marie-Tooth Disease Type 2n

Charcot-Marie-Tooth Disease 2n

Charcot-Marie-Tooth Disease Axonal Autosomal Dominant Type 2n

Charcot-Marie-Tooth Disease, Type 2n
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12268 RPS6KC1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus RPS6KC1 MGD MGI:2443419
Rattus norvegicus RPS6KC1 RGD RGD:1306578
Macaca mulatta RPS6KC1 VGNC VGNC:76935
Canis familiaris RPS6KC1 VGNC VGNC:45746
Felis catus RPS6KC1 VGNC VGNC:97613
Bos taurus RPS6KC1 VGNC VGNC:34148
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