Grm4 - glutamate receptor, metabotropic 4 Gene

中文名称：谷氨酸受体，代谢型 4

种属: Mus musculus

同用名: Gprc1d; mGluR4

关于 Grm4

功能概要

预测该基因编码的蛋白可使腺苷酸环化酶抑制G蛋白偶联谷氨酸受体活性；钙依赖性蛋白结合活性；和钙调蛋白结合活性。参与突触小泡胞吐的调节。在化学突触传递和学习的上游或内部起作用。位于神经元投射和平行纤维至浦肯野细胞突触。是突触前活动区膜的组成部分。在谷氨酸能突触中活跃。在中枢神经系统中表达；背根神经节；脚;感觉器官；和骨架。与人类 GRM4（谷氨酸代谢受体 4）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable Adenylate Cyclase inhibiting G protein-coupled glutamate receptor activity; calcium-dependent protein binding activity; and Calmodulin binding activity. Involved in regulation of synaptic vesicle exocytosis. Acts upstream of or within chemical synaptic transmission and learning. Located in neuron projection and parallel fiber to Purkinje cell synapse. Is integral component of presynaptic active zone membrane. Is active in glutamatergic synapse. Is expressed in central nervous system; dorsal root ganglion; foot; sensory organ; and skeleton. Orthologous to human GRM4 (glutamate metabotropic receptor 4). [provided by Alliance of Genome Resources, Apr 2022]