2. Gene
  3. GPR18 - G protein-coupled receptor 18 Gene

GPR18 - G protein-coupled receptor 18 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：G 蛋白偶联受体 18

种属: Homo sapiens

基因 ID: 2841 | 基因类型: protein coding

关于 GPR18

Cytogenetic location: 13q32.3 Genomic coordinates (GRCh38): 13:99,254,739-99,258,379 (from NCBI)

This gene has 5 transcripts (splice variants), 188 orthologues and 16 paralogues. Biased expression in lymph node (RPKM 11.0), testis (RPKM 4.7) and 4 other tissues.

功能概要

预计可启用 G 蛋白偶联受体活性。预计参与磷脂酶 C 激活 G 蛋白偶联信号通路中 Rho 蛋白信号转导的正向调节和胞质钙离子浓度的正向调节。预计在 T 细胞分化的上游或内部发挥作用；白细胞趋化性的负调节；和肿瘤坏死因子产生的负调节。预测位于质膜中。预计是质膜的组成部分。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable G protein-coupled receptor activity. Predicted to be involved in positive regulation of Rho protein signal transduction and positive regulation of cytosolic calcium ion concentration involved in Phospholipase C-activating G protein-coupled signaling pathway. Predicted to act upstream of or within T cell differentiation; negative regulation of leukocyte chemotaxis; and negative regulation of tumor necrosis factor production. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

GPR18 基因产物(2)

mRNA Protein Name
NM_001098200.2 NP_001091670.1 N-arachidonyl glycine receptor
NM_005292.4 NP_005283.1 N-arachidonyl glycine receptor

GPR18 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (40 - 286)

  • 0
  • 100
  • 200
  • 300
  • 331 a.a.
蛋白主名 其他名称

N-arachidonyl glycine receptor

NAGly receptor

关联疾病

疾病名称 别名
Lennox-Gastaut Syndrome

Lennox Syndrome

Encephalopathy Of Childhood

Epileptic Encephalopathy Lennox-Gastaut Type

Childhood Epileptic Encephalopathy With Diffuse Slow Spikes And Waves

Lgs
Dravet Syndrome

Severe Myoclonic Epilepsy Of Infancy

Severe Myoclonic Epilepsy In Infancy

Smei

Epileptic Encephalopathy, Early Infantile, 6

DRVT

Developmental And Epileptic Encephalopathy 6a

Dee6a

Eiee6

Developmental And Epileptic Encephalopathy, 6

Dee6

Developmental And Epileptic Encephalopathy 6

Early Infantile Epileptic Encephalopathy 6

Myoclonic Epilepsy, Severe, Of Infancy

Sme

Severe Myoclonus Epilepsy Of Infancy

Borderline Smei

Smeb

Smeb-M

Smeb-O

Smeb-Sw

Smei-Borderland

Smei-Borderland More Than One Feature

Smei-Borderland-Myoclonic Seizures

Smei-Borderland-Spike Wave

Intractable Childhood Epilepsy With Generalized Tonic-Clonic Seizures

ICEGTC

Infantile Severe Myoclonic Epilepsy

Epilepsy, Intractable Childhood, With Generalized Tonic-Clonic Seizures
Developmental And Epileptic Encephalopathy

Encephalopathy, Developmental And Epileptic
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (10)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-10863 Anandamide ≥99.0% 否
HY-103332 N-Arachidonylglycine Inhibitor 98.90% 否
HY-103335 O1918 Antagonist 96.60% 否
HY-162617 PSB-KK1415 Agonist 99.92% 否
HY-103332S N-Arachidonylglycine-d8 Inhibitor 98.1% 否
HY-10863S Anandamide-d8 99.90% 否
HY-10863S1 Anandamide-d11 / 否
HY-162618 PSB-KK1445 Agonist / 否
HY-RS05687 GPR18 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-138121 PSB-KD107 Agonist / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus GPR18 VGNC VGNC:29574
Mus musculus GPR18 MGD MGI:107859
Felis catus GPR18 VGNC VGNC:67418
Rattus norvegicus GPR18 RGD RGD:1304889
Macaca mulatta GPR18 VGNC VGNC:73127
Canis familiaris GPR18 VGNC VGNC:41420
Others GPR18 NCBI
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