Cxcr2 - C-X-C motif chemokine receptor 2 Gene

中文名称：CXC 基序趋化因子受体 2

种属: Rattus norvegicus

同用名: Il8rb; Cmkar2

基因 ID: 29385 | 基因类型: protein coding

关于 Cxcr2

Primary_assembly 9: 75,729,115-75,739,425 forward strand.mRatBN7.2:CM026982.1

This gene has 1 transcript (splice variant), 244 orthologues, 24 paralogues and is associated with 45 phenotypes. Biased expression in Spleen (RPKM 23.5), Lung (RPKM 14.1) and 4 other tissues.

功能概要

预测该基因编码的蛋白可启动趋化因子结合活性和趋化因子受体活性。参与多个过程，包括中性粒细胞趋化性；中性粒细胞趋化性的正向调节；和细胞凋亡过程的调节。预计位于多个细胞成分中，包括细胞表面；肥大细胞颗粒；和有丝分裂纺锤体。预计在质膜外侧活跃。用于研究结肠炎；脱髓鞘疾病；和肾炎。根尖周炎的生物标志物。与 IgA 肾小球肾炎有关的该基因的人类直系同源物；急性肾盂肾炎;晚期肾脏疾病;和膀胱癌。与人 CXCR2（CXC 基序趋化因子受体 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable chemokine binding activity and Chemokine Receptor activity. Involved in several processes, including neutrophil chemotaxis; positive regulation of neutrophil chemotaxis; and regulation of apoptotic process. Predicted to be located in several cellular components, including cell surface; mast cell granule; and mitotic spindle. Predicted to be active in external side of plasma membrane. Used to study colitis; demyelinating disease; and nephritis. Biomarker of periapical periodontitis. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; acute pyelonephritis; end stage renal disease; and urinary bladder Cancer. Orthologous to human CXCR2 (C-X-C motif Chemokine Receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Cxcr2 基因产物(1)

mRNA	Protein	Name
NM_017183.2	NP_058879.1	C-X-C chemokine receptor type 2

基因本体论

生物过程

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in acute inflammatory response to antigenic stimulus	IMP IMP: 通过突变表型推断	15516486	RGD
involved in metanephric tubule morphogenesis	IMP IMP: 通过突变表型推断	17634442	RGD
involved in midbrain development	IEP IEP: 通过表达模式推断	18436867	RGD
involved in negative regulation of apoptotic process	IMP IMP: 通过突变表型推断	17634442	RGD
involved in negative regulation of neutrophil apoptotic process	IMP IMP: 通过突变表型推断	22312020	RGD
involved in neutrophil chemotaxis	IMP IMP: 通过突变表型推断	10975996	RGD
involved in positive regulation of angiogenesis	IMP IMP: 通过突变表型推断	18832730	RGD
involved in positive regulation of cardiac muscle cell apoptotic process	IMP IMP: 通过突变表型推断	22562555	RGD
involved in positive regulation of cytosolic calcium ion concentration	IDA IDA: 通过直接分析推断	10975996	RGD
involved in positive regulation of leukocyte chemotaxis	IMP IMP: 通过突变表型推断	17717298	RGD
involved in positive regulation of neutrophil chemotaxis	IMP IMP: 通过突变表型推断	23947621	RGD
involved in positive regulation of vascular permeability	IMP IMP: 通过突变表型推断	19255141	RGD

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Cxcr2 蛋白结构

7tmA_CXCR1_2

0
100
200
300
359 a.a.

蛋白主名

其他名称

C-X-C chemokine receptor type 2

CXC-R2	CXCR-2
GRO/MGSA receptor	IL-8R B
chemokine (C-X-C motif) receptor 2	chemokine (C-X-C) receptor 2
high affinity interleukin-8 receptor B	interleukin 8 receptor, beta

相关产品

Clinical Phase

生物活性分子 (11)

目录号	产品名	作用方式	纯度	Phase
HY-15251	Reparixin	Inhibitor	99.95%	Phase 3
HY-15252	Reparixin L-lysine salt	Inhibitor	99.66%	Phase 3
HY-19519A	Ladarixin sodium	Antagonist	99.84%	Phase 3
HY-10198	Navarixin	Antagonist	98.90%	Phase 2
HY-13848	AZD8797		99.54%	Phase 2
HY-19855	AZD-5069	Antagonist	99.91%	Phase 2
HY-119339	SX-682	Inhibitor	99.67%	Phase 2
HY-50688	SB-265610	Antagonist	≥99.0%	Phase 2
HY-19768	Danirixin	Antagonist	98.88%	Phase 2
HY-18263C	Elubrixin tosylate	Antagonist	99.78%	Phase 2
HY-18263A	Elubrixin	Antagonist	/	Phase 2

Pre-clinical Phase

生物活性分子 (18)

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-16711	SB225002	Antagonist	99.87%	否
HY-101407	Nicotinamide N-oxide	Antagonist	99.85%	否
HY-147392	CXCR2 antagonist 8	Antagonist	99.24%	否
HY-101022	CXCR2-IN-1	Inhibitor	99.47%	否
HY-120878	CXCR2-IN-2	Antagonist	99.52%	否
HY-12927	SX-517	Antagonist	99.88%	否
HY-10011	SCH 563705	Antagonist	99.86%	否
HY-13021	SRT3190	Antagonist	99.77%	否
HY-119259	AZD8309	Antagonist	99.98%	否
HY-15462	SRT3109	Antagonist	99.82%	否
HY-144784	CXCR2 antagonist 7	Antagonist	/	否
HY-144780	CXCR2 antagonist 4	Antagonist	/	否
HY-124056	AZ10397767	Antagonist	/	否
HY-101407R	Nicotinamide N-oxide (Standard)	Antagonist	/	否
HY-N2573	Corydalmine	Inhibitor	/	否
HY-144783	CXCR2 antagonist 6	Antagonist	/	否
HY-144781	CXCR2 antagonist 5	Antagonist	/	否
HY-P4846	Ac-Pro-Gly-Pro-OH	Agonist	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Cxcr2	NCBI	NCBI:3579
Mus musculus	Cxcr2	NCBI	NCBI:12765

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