2. Anti-infection Immunology/Inflammation GPCR/G Protein
  3. Fungal CXCR
  4. Corydalmine

Corydalmine  (Synonyms: L-Corydalmine; TLZ-16)

目录号: HY-N2573
产品使用指南

摩尔计算器

Corydalmine (L-Corydalmine) 抑制某些植物病原体的孢子萌发以及腐生真菌。Corydalmine 具有口服活性，可用于缓解疼痛的研究。Corydalmine 通过抑制 NF-κB 依赖性的 CXCL1/CXCR2 信号传导途径，可缓解 Vincristine 引起的神经性疼痛。

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Corydalmine Chemical Structure

Corydalmine Chemical Structure

CAS No. : 30413-84-4

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Corydalmine 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Corydalmine (L-Corydalmine) inhibits spore germination of some plant pathogenic as well as saprophytic fungi[1]. Corydalmine acts as an oral analgesic agent, exhibiting potent analgesic activity[2]. Corydalmine alleviates Vincristine-induced neuropathic pain in mice by inhibiting an NF-κB-dependent CXCL1/CXCR2 signaling pathway[3].

IC50 & Target[3]

CXCR2

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 EC50
0.19 μM
Compound: 18k
Agonist activity at 5-HT1A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assay
Agonist activity at 5-HT1A receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assay
[PMID: 23332346]
HEK293 EC50
1.35 μM
Compound: 18k
Agonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding by scintillation proximity assay
Agonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding by scintillation proximity assay
[PMID: 23332346]
HEK293 IC50
18.73 μM
Compound: 18k
Antagonist activity at dopamine D2 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assay
Antagonist activity at dopamine D2 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assay
[PMID: 23332346]
HEK293 IC50
21.27 μM
Compound: 18k
Antagonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assay
Antagonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assay
[PMID: 23332346]
THP-1 IC50
152.43 nM
Compound: 6
Inhibition of tissue factor procoagulant activity in LPS-stimulated human THP1 cells preincubated for 1 hr before LPS addition measured after 5 hrs
Inhibition of tissue factor procoagulant activity in LPS-stimulated human THP1 cells preincubated for 1 hr before LPS addition measured after 5 hrs
[PMID: 23199480]
体内研究
(In Vivo)

Corydalmine (L-Corydalmine) is a potent analgesic agent, in cynomolgus monkey, beagle dog, rat and mouse liver microsomes[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

341.40

Formula

C20H23NO4
CAS 号
中文名称

紫堇达明碱
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Corydalmine 相关分类

  • 摩尔计算器

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Corydalmine30413-84-4L-Corydalmine TLZ-16紫堇达明碱TLZ16TLZ 16TLZ-16FungalCXCRCXC chemokine receptorsC-X-C motif chemokine receptorsInhibitorinhibitorinhibit

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