2. GPCR/G Protein Immunology/Inflammation
  3. CXCR
  4. CXCR2-IN-1

CXCR2-IN-1是可渗透中枢神经系统的CXCR2拮抗剂，pIC50值为9.3。

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CXCR2-IN-1 Chemical Structure

CXCR2-IN-1 Chemical Structure

CAS No. : 1873376-49-8

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥940
In-stock
1 mg ￥500
In-stock
5 mg ￥900
In-stock
10 mg ￥1500
In-stock
25 mg ￥3000
In-stock
50 mg ￥4900
In-stock
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

Customer Review

CXCR2-IN-1 相关抗体

Top Publications Citing Use of Products

查看 CXCR 亚型特异性产品:

查看所有亚型
CXCR CXCR1 CXCR2 CXCR3 CXCR4 CXCR7 CXCR6

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

CXCR2-IN-1 is a central nervous system penetrant CXCR2 antagonist with a pIC50 of 9.3.

IC50 & Target[1]

CXCR2

9.3 (pIC50)

体外研究
(In Vitro)

CXCR2 plays an important role in the activation and recruitment of neutrophils to sites of inflammation. CXCR2-IN-1 (compound 22) shows favorable central nervous system penetration property (Br/Bl>0.45)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CXCR2-IN-1 相关抗体:
体内研究
(In Vivo)

CXCR2-IN-1 shows efficacy in a cuprizone-induced demyelination model through oral administration, providing evidence to support CXCR2 to be a potential therapeutic target to treat demyelinating diseases such as multiple sclerosis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

476.35

Formula

C19H20Cl2FN3O4S
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 5.4 mg/mL (11.34 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.0993 mL 10.4965 mL 20.9930 mL
5 mM 0.4199 mL 2.0993 mL 4.1986 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献
Animal Administration
[1]

Mice: Mice are fed with cuprizone for 5 weeks to cause demyelinating lesions in the CNS and then orally administrated with CXCR2-IN-1 for 9 consecutive days at doses of 30 and 100 mg/kg twice daily[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

CXCR2-IN-1 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0993 mL 10.4965 mL 20.9930 mL 52.4824 mL
5 mM 0.4199 mL 2.0993 mL 4.1986 mL 10.4965 mL
10 mM 0.2099 mL 1.0496 mL 2.0993 mL 5.2482 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CXCR2-IN-11873376-49-8CXCRCXC chemokine receptorsC-X-C motif chemokine receptorsInhibitorinhibitorinhibit

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产品名称：
CXCR2-IN-1
目录号：
HY-101022
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