RORA - RAR-related orphan receptor A Gene

中文名称：RAR 相关孤儿受体 A

种属: Rattus norvegicus

关于 RORA

功能概要

该基因编码的蛋白质是核激素受体 NR1 亚家族的成员。它可以作为单体或作为同型二聚体与几个基因上游的激素反应元件结合，以增强这些基因的表达。编码的蛋白质已显示与 NM23-2 相互作用，NM23-2 是一种参与器官发生和分化的核苷二磷酸激酶，以及与肿瘤转移抑制候选基因的产物 NM23-1 相互作用。此外，它已被证明有助于某些与昼夜节律有关的基因的转录调节。 [RefSeq 提供，2014 年 2 月]

The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm. [provided by RefSeq, Feb 2014]