RORA - RAR related orphan receptor A Gene

中文名称：RAR 相关孤儿受体 A

种属: Homo sapiens

同用名: ROR1; ROR2; ROR3; RZRA; NR1F1; IDDECA; RZR-ALPHA

基因 ID: 6095 | 基因类型: protein coding

关于 RORA

Cytogenetic location: 15q22.2 Genomic coordinates (GRCh38): 15:60,488,284-61,229,302 (from NCBI)

This gene has 14 transcripts (splice variants), 395 orthologues, 18 paralogues and is associated with 2 phenotypes. Broad expression in skin (RPKM 15.9), adrenal (RPKM 10.1) and 21 other tissues.

功能概要

该基因编码的蛋白质是核激素受体 NR1 亚家族的成员。它可以作为单体或作为同型二聚体与几个基因上游的激素反应元件结合，以增强这些基因的表达。编码的蛋白质已显示与 NM23-2 相互作用，NM23-2 是一种参与器官发生和分化的核苷二磷酸激酶，以及与肿瘤转移抑制候选基因的产物 NM23-1 相互作用。此外，它已被证明有助于某些与昼夜节律有关的基因的转录调节。已针对该基因描述了编码不同亚型的四种转录物变体。[RefSeq 提供，2014 年 2 月]

The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2014]

RORA 基因产物(11)

mRNA	Protein	Name
XM_047432928.1	XP_047288884.1	nuclear receptor ROR-alpha isoform X4
XM_011521877.4	XP_011520179.1	nuclear receptor ROR-alpha isoform X3
NM_134260.3	NP_599022.1	nuclear receptor ROR-alpha isoform b
XM_011521874.2	XP_011520176.1	nuclear receptor ROR-alpha isoform X1
XM_011521879.4	XP_011520181.1	nuclear receptor ROR-alpha isoform X5
NM_134261.3	NP_599023.1	nuclear receptor ROR-alpha isoform a
XM_011521875.3	XP_011520177.1	nuclear receptor ROR-alpha isoform X2
XM_047432929.1	XP_047288885.1	nuclear receptor ROR-alpha isoform X4
XM_047432930.1	XP_047288886.1	nuclear receptor ROR-alpha isoform X4
NM_002943.4	NP_002934.1	nuclear receptor ROR-alpha isoform c
NM_134262.3	NP_599024.1	nuclear receptor ROR-alpha isoform d

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA binding	IDA IDA: 通过直接分析推断	7926749	GOA
enables DNA-binding transcription factor activity	IDA IDA: 通过直接分析推断	7926749	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	21628546	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	19955433	GOA
enables ligand-activated transcription factor activity	IDA IDA: 通过直接分析推断	19965867	GOA
enables oxysterol binding	IDA IDA: 通过直接分析推断	19965867	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	9862959	GOA
enables sequence-specific DNA binding	IDA IDA: 通过直接分析推断	11053433	GOA
enables transcription coactivator binding	IPI IPI: 通过物理相互作用推断	9862959	GOA
enables transcription coregulator binding	IPI IPI: 通过物理相互作用推断	14701856	GOA
enables transcription corepressor binding	IPI IPI: 通过物理相互作用推断	9328355	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in angiogenesis	IMP IMP: 通过突变表型推断	18658046	GOA
involved in cellular response to hypoxia	IMP IMP: 通过突变表型推断	18658046	GOA
involved in cellular response to sterol	IDA IDA: 通过直接分析推断	19965867	GOA
involved in cellular response to sterol	IMP IMP: 通过突变表型推断	18658046	GOA
involved in intracellular receptor signaling pathway	IDA IDA: 通过直接分析推断	19965867	GOA
involved in muscle cell differentiation	IMP IMP: 通过突变表型推断	9862959	GOA
involved in negative regulation of canonical NF-kappaB signal transduction	IMP IMP: 通过突变表型推断	11252722	GOA
involved in negative regulation of inflammatory response	IMP IMP: 通过突变表型推断	11252722	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	7926749	GOA
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	17545671	GOA
involved in positive regulation of vascular endothelial growth factor production	IMP IMP: 通过突变表型推断	18658046	GOA
involved in regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	9328355	GOA
involved in triglyceride homeostasis	IMP IMP: 通过突变表型推断	11053433	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in nucleus	IDA IDA: 通过直接分析推断	18658046	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RORA 蛋白结构

zf-C4

Hormone_recep

0
100
200
300
400
523 a.a.

蛋白主名

其他名称

nuclear receptor ROR-alpha

ROR-alpha	nuclear receptor RZR-alpha
nuclear receptor subfamily 1 group F member 1	retinoic acid receptor-related orphan receptor alpha
retinoid-related orphan receptor alpha	transcription factor RZR-alpha

RORA 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	RORA	P35398	GFAP	Homo sapiens	P14136	Y2H Prey Pooling	25416956
种属内	RORA	P35398	NR0B1	Homo sapiens	P51843	Pull Down	16713569

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Epilepsy

Epilepsy Syndrome	Epileptic Syndrome
Epilepsies	Symptomatic Epilepsies
Post Traumatic Epilepsy	Traumatic Epilepsy
Traumatic Epileptic	Epilepsy Due To Hippocampal Sclerosis
Epilepsy With Ammon'S Horn Sclerosis	Epilepsy Due To Cortical Dysplasia
Epilepsy Due To Neuronal Migration Disorders

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Spinocerebellar Ataxia 1

Spinocerebellar Ataxia Type 1	SCA1
Olivopontocerebellar Atrophy I	Opca1
Opca4	Menzel Type Opca
Schut-Haymaker Type Opca	Spinocerebellar Atrophy I
Opca I	Olivopontocerebellar Atrophy Iv
Opca Iv	Cerebelloparenchymal Disorder I
Cpd1	Olivopontocerebellar Atrophy 1
Cerebelloparenchymal Disorder 1	Olivopontocerebellar Atrophy 4
Spinocerebellar Atrophy 1	Type 1 Spinocerebellar Ataxia
Spinocerebellar Ataxia-1	Ataxia, Spinocerebellar, Type 1

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Intellectual Developmental Disorder With Or Without Epilepsy Or Cerebellar Ataxia

IDDECA

Robinow Syndrome

Acral Dysostosis With Facial And Genital Abnormalities	Fetal Face Syndrome
Robinow Dwarfism	Mesomelic Dwarfism-Small Genitalia Syndrome
Robinow-Silverman-Smith Syndrome	Costovertebral Segmentation Defect With Mesomelia
Covesdem Syndrome	Robinow'S Syndrome
Robinow-Silverman Syndrome

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Bronchiectasis 3

Robinow Syndrome, Autosomal Recessive 1

Robinow Syndrome, Autosomal Recessive	Autosomal Recessive Robinow Syndrome
Covesdem Syndrome	RRS1
Costovertebral Segmentation Defect-Mesomelia Syndrome	Rrs
Costovertebral Segmentation Defect With Mesomelia, Formerly	Covesdem Syndrome, Formerly
Costovertebral Segmentation Defect With Mesomelia	Robinow Syndrome Autosomal Recessive With Aplasia/Hypoplasia Of Phalanges And Metacarpals/Metatarsals
Robinow Syndrome Autosomal Recessive With Brachy-Syn-Polydactyly	Robinow Syndrome, Autosomal Recessive, With Aplasia/Hypoplasia Of Phalanges And Metacarpals/Metatarsals
Robinow Syndrome, Autosomal Recessive, With Brachy-Syn-Polydactyly	Robinow, Autosomal Recessive Syndrome, Type 1

Epidermolysis Bullosa Acquisita

Acquired Epidermolysis Bullosa	Eb Acquisita
Eba	Eba - [Epidermolysis Bullosa Acquisita]

Major Depressive Disorder

Seasonal Affective Disorder	Unipolar Depression
Depression	MDD
Depressive Disorder	Unipolar Depression, Susceptibility To
Major Depressive Disorder 1	Major Depressive Disorder, Response To Citalopram Therapy In
Major Depressive Disorder 2	Winter Depression
Single Major Depressive Episode	Sad
Clinical Depression	Major Depression
Depressive Syndrome	Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment
Seasonal Affective Disorder, Susceptibility To	Recurrent Major Depression
Affective Disorder, Seasonal	Depression In A Seasonal Pattern
Depression	Seasonal
Major Depressive Disorder With A Seasonal Pattern	Seasonal Depression
Seasonal Mood Disorder	Mental Depression
Recurrent Major Depressive Episodes

Advanced Sleep Phase Syndrome

Fasps	Familial Advanced Sleep-Phase Syndrome
Advanced Sleep Phase Syndrome, Familial	Familial Advanced Sleep Phase Syndrome
Sleep Phase Syndrome, Advanced, Familial	Advanced Sleep-Phase Syndrome, Familial

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS12126	RORA Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS12127	Rora Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS12128	RORA Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	RORA	VGNC	VGNC:76717
Felis catus	RORA	VGNC	VGNC:64721
Canis familiaris	RORA	VGNC	VGNC:45695
Mus musculus	RORA	MGD	MGI:104661
Rattus norvegicus	RORA	RGD	RGD:1308419
Bos taurus	RORA	VGNC	VGNC:34088
Others	RORA	NCBI

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

RORA - RAR related orphan receptor A Gene

关于 RORA

功能概要

RORA 基因产物(11)

RORA 蛋白结构

RORA 蛋白互作信息

关联疾病

直系同源

热门区域

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RORA - RAR related orphan receptor A Gene

关于 RORA

功能概要

RORA 基因产物(11)

RORA 蛋白结构

RORA 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z