2. Gene
  3. KLC1 - kinesin light chain 1 Gene

KLC1 - kinesin light chain 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：驱动蛋白轻链 1

种属: Homo sapiens

同用名: KLC; KNS2; KNS2A

基因 ID: 3831 | 基因类型: protein coding

关于 KLC1

Cytogenetic location: 14q32.33 Genomic coordinates (GRCh38): 14:103,629,211-103,701,544 (from NCBI)

This gene has 27 transcripts (splice variants), 215 orthologues and 5 paralogues. Broad expression in brain (RPKM 108.4), heart (RPKM 21.0) and 23 other tissues.

功能概要

常规驱动蛋白是由两条重链和两条轻链组成的四聚体分子，并沿着微管向其正端运输各种货物。重链提供运动活动，而轻链则与各种货物结合。该基因编码驱动蛋白轻链家族的一个成员。它通过 N 末端结构域与驱动蛋白重链相关联，并且六个四肽重复 (TPR) 基序被认为与囊泡、线粒体和高尔基复合体等货物的结合有关。因此，驱动蛋白轻链起衔接分子的作用，而不是马达本身。虽然以前命名为“驱动蛋白 2”，但该基因不是驱动蛋白运动蛋白的驱动蛋白 2 / 驱动蛋白重链亚家族的成员。广泛的选择性剪接产生具有不同 C 末端的亚型，这些亚型被提议与不同的货物结合；然而，大多数这些变体的全长性质和/或生物学有效性尚未确定。[RefSeq 提供，2008 年 7 月]

Conventional Kinesin is a tetrameric molecule composed of two heavy chains and two LIGHT chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the LIGHT chains bind to various cargos. This gene encodes a member of the Kinesin light chain family. It associates with Kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, Kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / Kinesin heavy chain subfamily of Kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or biological validity of most of these variants have not been determined. [provided by RefSeq, Jul 2008]

KLC1 基因产物(32)

mRNA Protein Name
NM_001130107.2 NP_001123579.1 kinesin light chain 1 isoform 3
NM_001394832.1 NP_001381761.1 kinesin light chain 1 isoform 4
NM_001394833.1 NP_001381762.1 kinesin light chain 1 isoform 5
NM_001394834.1 NP_001381763.1 kinesin light chain 1 isoform 6
NM_001394835.1 NP_001381764.1 kinesin light chain 1 isoform 7
NM_001394836.1 NP_001381765.1 kinesin light chain 1 isoform 8
NM_001394837.1 NP_001381766.1 kinesin light chain 1 isoform 9
NM_001394838.1 NP_001381767.1 kinesin light chain 1 isoform 10
NM_001394839.1 NP_001381768.1 kinesin light chain 1 isoform 11
NM_001394840.1 NP_001381769.1 kinesin light chain 1 isoform 12
NM_001394841.1 NP_001381770.1 kinesin light chain 1 isoform 13
NM_001394842.1 NP_001381771.1 kinesin light chain 1 isoform 14
NM_001394843.1 NP_001381772.1 kinesin light chain 1 isoform 15
NM_001394844.1 NP_001381773.1 kinesin light chain 1 isoform 16
NM_001394845.1 NP_001381774.1 kinesin light chain 1 isoform 17
NM_001394846.1 NP_001381775.1 kinesin light chain 1 isoform 18
NM_001394847.1 NP_001381776.1 kinesin light chain 1 isoform 19
NM_001394848.1 NP_001381777.1 kinesin light chain 1 isoform 20
NM_001394849.1 NP_001381778.1 kinesin light chain 1 isoform 21
NM_001394850.1 NP_001381779.1 kinesin light chain 1 isoform 22
NM_001394851.1 NP_001381780.1 kinesin light chain 1 isoform 23
NM_001394852.1 NP_001381781.1 kinesin light chain 1 isoform 24
NM_001394853.1 NP_001381782.1 kinesin light chain 1 isoform 25
NM_001394854.1 NP_001381783.1 kinesin light chain 1 isoform 26
NM_001394855.1 NP_001381784.1 kinesin light chain 1 isoform 27
NM_001394856.1 NP_001381785.1 kinesin light chain 1 isoform 28
NM_001394857.1 NP_001381786.1 kinesin light chain 1 isoform 29
NM_001394858.1 NP_001381787.1 kinesin light chain 1 isoform 30
NM_001394859.1 NP_001381788.1 kinesin light chain 1 isoform 31
NM_001394860.1 NP_001381789.1 kinesin light chain 1 isoform 32
NM_005552.5 NP_005543.2 kinesin light chain 1 isoform 1
NM_182923.4 NP_891553.2 kinesin light chain 1 isoform 2
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
14970196 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KLC1 蛋白结构

Rab5-bind

Rab5-bind: Rabaptin-like protein (80 - 254)

TPR_2

TPR_2: Tetratricopeptide repeat (258 - 285)

TPR_12

TPR_12: Tetratricopeptide repeat (293 - 370)

TPR_1

TPR_1: Tetratricopeptide repeat (381 - 410)

TPR_10

TPR_10: Tetratricopeptide repeat (465 - 495)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 573 a.a.
蛋白主名 其他名称

kinesin light chain 1

kinesin 2 60/70kDa

KLC1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra KLC1 Q07866 BNIP2 Homo sapiens Q12982
Validated Y2H
25416956
Intra KLC1 Q07866 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Melanoma, Cutaneous Malignant 6

Melanoma, Cutaneous Malignant, Susceptibility To, 6

CMM6

Melanoma, Cutaneous Malignant, 6

Cutaneous Malignant Melanoma 6

Melanoma, Cutaneous, Malignant, Susceptibility To, Type 6
Lung Combined Large Cell Neuroendocrine Carcinoma

Combined Large Cell Neuroendocrine Carcinoma Of Lung

Pulmonary Combined Large Cell Neuroendocrine Carcinoma

Combined Large Cell Lung Neuroendocrine Carcinoma
Occipital Lobe Neoplasm

Neoplasm Of Occipital Lobe

Malignant Neoplasm Of Occipital Lobe

Tumor Of Occipital Lobe
Cataract 28

CTRCT28

Cataract, Age-Related Cortical, 1

Arcc1

Cataract 28, Age-Related Cortical, Susceptibility To

Cataract 28, Age-Related Cortical

Age-Related Cortical Cataract 1
Medulloblastoma

MDB

Cpnet

Localized Primitive Neuroectodermal Tumor

Classic Medulloblastoma

Medulloblastoma Predisposition Syndrome

Medulloblastoma, Somatic

Brain Medulloblastoma

Cns Pnet

Infratentorial Primitive Neuroectodermal Tumor

Neuroectodermal Tumors, Primitive

Medulloblastomas

Desmoplastic Medulloblastoma

Medulloblastoma, With Extensive Nodularity

Medulloblastoma Of Unspecified Site

Medullomyoblastoma Of Unspecified Site
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Inflammatory Myofibroblastic Tumor

Inflammatory Fibrosarcoma
Dystonia

Dystonic Disease

Dystonic Disorder

Dystonia Disorders

Neuroleptic Dyskinesia
Bardet-Biedl Syndrome

Bbs

Biedl-Bardet Syndrome
Hereditary Spastic Paraplegia

Familial Spastic Paraplegia

Hereditary Spastic Paraparesis

Strumpell-Lorrain Disease

Familial Spastic Paraparesis

Hsp

Spg

Strümpell-Lorrain Disease

Spastic Paraplegia, Hereditary

French Settlement Disease

Strumpell-Lorrain Syndrome

Fsp

Spastic Paraplegia, Familial

Spastic Paraplegia Hereditary

Spastic Paraplegia 3, Autosomal Dominant

Spastic Paraparesis

Hereditary Spastic Paralysis

Familial Spastic Paralysis

Hereditary Spastic Ataxia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07326 KLC1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus KLC1 MGD MGI:107978
Felis catus KLC1 VGNC VGNC:104480
Rattus norvegicus KLC1 RGD RGD:621411
Others KLC1 NCBI
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