2. Gene
  3. KTN1 - kinectin 1 Gene

KTN1 - kinectin 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：激动素 1

种属: Homo sapiens

同用名: CG1; KNT; MU-RMS-40.19

基因 ID: 3895 | 基因类型: protein coding

关于 KTN1

Cytogenetic location: 14q22.3 Genomic coordinates (GRCh38): 14:55,580,207-55,684,584 (from NCBI)

This gene has 25 transcripts (splice variants), 206 orthologues and is associated with 76 phenotypes. Ubiquitous expression in testis (RPKM 35.7), thyroid (RPKM 26.9) and 25 other tissues.

功能概要

该基因编码一种完整的膜蛋白，它是激动素蛋白家族的一员。编码的蛋白质主要定位于内质网膜。这种蛋白质结合驱动蛋白并可能参与细胞内细胞器运动。该蛋白质还结合翻译延伸因子-δ，并可能参与延伸因子-1 复合物的组装。交替剪接导致该基因的多个转录变体。[RefSeq 提供，2012 年 8 月]

This gene encodes an integral membrane protein that is a member of the kinectin protein family. The encoded protein is primarily localized to the endoplasmic reticulum membrane. This protein binds Kinesin and may be involved in intracellular organelle motility. This protein also binds translation elongation factor-delta and may be involved in the assembly of the elongation factor-1 complex. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Aug 2012]

KTN1 基因产物(32)

mRNA Protein Name
NM_001079521.2 NP_001072989.1 kinectin isoform a
NM_001079522.2 NP_001072990.1 kinectin isoform b
NM_001271014.2 NP_001257943.1 kinectin isoform d
NM_001402682.1 NP_001389611.1 kinectin isoform a
NM_001402683.1 NP_001389612.1 kinectin isoform 5
NM_001402684.1 NP_001389613.1 kinectin isoform 6
NM_001402685.1 NP_001389614.1 kinectin isoform d
NM_001402686.1 NP_001389615.1 kinectin isoform d
NM_001402687.1 NP_001389616.1 kinectin isoform 7
NM_001402688.1 NP_001389617.1 kinectin isoform 7
NM_001402689.1 NP_001389618.1 kinectin isoform 7
NM_001402690.1 NP_001389619.1 kinectin isoform b
NM_001402691.1 NP_001389620.1 kinectin isoform b
NM_001402692.1 NP_001389621.1 kinectin isoform 8
NM_001402693.1 NP_001389622.1 kinectin isoform c
NM_001402694.1 NP_001389623.1 kinectin isoform c
NM_001402696.1 NP_001389625.1 kinectin isoform 9
NM_001402698.1 NP_001389627.1 kinectin isoform 10
NM_001402699.1 NP_001389628.1 kinectin isoform 11
NM_001402700.1 NP_001389629.1 kinectin isoform 11
NM_001402701.1 NP_001389630.1 kinectin isoform 12
NM_001402702.1 NP_001389631.1 kinectin isoform 12
NM_001402703.1 NP_001389632.1 kinectin isoform 13
NM_001402704.1 NP_001389633.1 kinectin isoform 14
NM_001402705.1 NP_001389634.1 kinectin isoform 14
NM_001402706.1 NP_001389635.1 kinectin isoform 15
NM_001402707.1 NP_001389636.1 kinectin isoform 16
NM_001402708.1 NP_001389637.1 kinectin isoform 17
NM_001402709.1 NP_001389638.1 kinectin isoform 18
NM_001402710.1 NP_001389639.1 kinectin isoform 19
NM_001402711.1 NP_001389640.1 kinectin isoform 20
NM_004986.4 NP_004977.2 kinectin isoform c
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

kinectin

CG-1 antigen

KTN1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra KTN1 Q86UP2 SGTA Homo sapiens O43765
Y2H Prey Pooling
25416956
Intra KTN1 Q86UP2 CLEC7A Homo sapiens Q9BXN2
Y2H Prey Pooling
25416956
Intra KTN1 Q86UP2 SYNE4 Homo sapiens Q8N205
Y2H Array
25416956
Intra KTN1 Q86UP2 MEOX2 Homo sapiens P50222
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Gliofibroma
Hereditary Spastic Paraplegia

Familial Spastic Paraplegia

Hereditary Spastic Paraparesis

Strumpell-Lorrain Disease

Familial Spastic Paraparesis

Hsp

Spg

Strümpell-Lorrain Disease

Spastic Paraplegia, Hereditary

French Settlement Disease

Strumpell-Lorrain Syndrome

Fsp

Spastic Paraplegia, Familial

Spastic Paraplegia Hereditary

Spastic Paraplegia 3, Autosomal Dominant

Spastic Paraparesis

Hereditary Spastic Paralysis

Familial Spastic Paralysis

Hereditary Spastic Ataxia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07477 KTN1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus KTN1 RGD RGD:1308719
Bos taurus KTN1 VGNC VGNC:30756
Felis catus KTN1 VGNC VGNC:67997
Macaca mulatta KTN1 VGNC VGNC:74222
Canis familiaris KTN1 VGNC VGNC:42550
Mus musculus KTN1 MGD MGI:109153
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z