SNU13 - small nuclear ribonucleoprotein 13 Gene

中文名称：小核核糖核蛋白 13

种属: Homo sapiens

同用名: FA1; FA-1; NHPX; 15.5K; OTK27; SSFA1; NHP2L1; SPAG12; SNRNP15-5

基因 ID: 4809 | 基因类型: protein coding

关于 SNU13

Cytogenetic location: 22q13.2 Genomic coordinates (GRCh38): 22:41,673,933-41,690,480 (from NCBI)

This gene has 12 transcripts (splice variants) and 211 orthologues. Ubiquitous expression in brain (RPKM 32.6), adrenal (RPKM 31.2) and 25 other tissues.

功能概要

最初因其与酿酒酵母 NHP2 (非组蛋白蛋白 2) 的序列相似性而得名，该蛋白似乎是一种高度保守的核蛋白，是 [U4/U6.U5] 三 snRNP 的一个组成部分。它与 U4 snRNA 的 5' 茎环结合。已发现该基因编码相同蛋白质的两个转录变体。[RefSeq 提供，2008 年 7 月]

Originally named because of its sequence similarity to the Saccharomyces cerevisiae NHP2 (non-histone protein 2), this protein appears to be a highly conserved nuclear protein that is a component of the [U4/U6.U5] tri-snRNP. It binds to the 5' stem-loop of U4 snRNA. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

SNU13 基因产物(2)

mRNA	Protein	Name
NM_001003796.2	NP_001003796.1	NHP2-like protein 1
NM_005008.4	NP_004999.1	NHP2-like protein 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables ATPase binding	IPI IPI: 通过物理相互作用推断	17636026	GOA
enables U3 snoRNA binding	IDA IDA: 通过直接分析推断	11081632	GOA
enables U4 snRNA binding	IDA IDA: 通过直接分析推断	11081632	GOA
enables U4atac snRNA binding	IDA IDA: 通过直接分析推断	16857676	GOA
enables box C/D sno(s)RNA binding	IDA IDA: 通过直接分析推断	11081632	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	10593953	GOA
contributes to snoRNA binding	IDA IDA: 通过直接分析推断	17636026	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in mRNA splicing, via spliceosome	IDA IDA: 通过直接分析推断	28781166	GOA
involved in ribosomal small subunit biogenesis	IDA IDA: 通过直接分析推断	34516797	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of U2-type precatalytic spliceosome	IDA IDA: 通过直接分析推断	28781166	GOA
part of U4/U6 x U5 tri-snRNP complex	IDA IDA: 通过直接分析推断	26912367	GOA
part of U4/U6 x U5 tri-snRNP complex	IPI IPI: 通过物理相互作用推断	30975767	GOA
part of U4atac snRNP	IDA IDA: 通过直接分析推断	21784869	GOA
part of box C/D methylation guide snoRNP complex	IDA IDA: 通过直接分析推断	11081632	GOA
located in dense fibrillar component	IDA IDA: 通过直接分析推断	10593953	GOA
located in nucleolus	IDA IDA: 通过直接分析推断	10593953	GOA
located in nucleus	IDA IDA: 通过直接分析推断	28781166	GOA
part of protein-containing complex	IDA IDA: 通过直接分析推断	17636026	GOA
part of small-subunit processome	IDA IDA: 通过直接分析推断	34516797	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SNU13 蛋白结构

Ribosomal_L7Ae

0
100
128 a.a.

蛋白主名

其他名称

NHP2-like protein 1

NHP2 non-histone chromosome protein 2-like 1

SNU13 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	SNU13	P55769	NUFIP1	Homo sapiens	Q9UHK0	Pull Down	17636026
种属内	SNU13	P55769	SMN1	Homo sapiens	Q16637	Y2H Prey Pooling	32296183
种属内	SNU13	P55769	SMN1	Homo sapiens	Q16637	Validated Y2H	32296183
种属内	SNU13	P55769	SMN1	Homo sapiens	Q16637	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 SNU13 蛋白

目录号	产品名	蛋白编号	纯度
HY-P71161	NHP2L1 Protein, Human (His)	P55769 (M1-V128)	≥95%

关联疾病

疾病名称

别名

Microcephalic Osteodysplastic Primordial Dwarfism, Type I

Taybi-Linder Syndrome	Brachymelic Primordial Dwarfism
Cephaloskeletal Dysplasia	Low-Birth-Weight Dwarfism With Skeletal Dysplasia
Microcephalic Osteodysplastic Primordial Dwarfism Type I	Osteodysplastic Primordial Dwarfism Type I
Primordial Microcephalic Dwarfism, Crachami Type	Osteodysplastic Primordial Dwarfism, Type 1
MOPD1	Mopd I
Mopd	Osteodysplastic Primordial Dwarfism, Type I
Tals	Microcephalic Osteodysplastic Primordial Dwarfism Type 1
Mopd 1	Microcephalic Osteodysplastic Primordial Dwarfism Types 1 And 3
Microcephalic Osteodysplastic Primordial Dwarfism Types I And Iii	Mopd Types I And Iii
Microcephalic Osteodysplastic Primordial Dwarfism, Taybi-Linder Type	Primordial Microcephalic Dwarfism Crachami Type
Dwarfism, Primordial, Osteodysplastic, Microcephalic, Type 1

Dyskeratosis Congenita

Dyskeratosis Congenita Autosomal Dominant	Dc
Dkc	Zinsser-Engman-Cole Syndrome
Dyskeratosis Congenita, Autosomal Dominant	Autosomal Dominant Dyskeratosis Congenita
Dkca	Dyskeratosis Congenita Scoggins Type
Zinsser-Cole-Engman Syndrome	X-Linked Dyskeratosis Congenita
Hoyeraal-Hreidarsson Syndrome

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS13518	SNU13 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	SNU13	VGNC	VGNC:98450
Mus musculus	SNU13	MGD	MGI:893586
Rattus norvegicus	SNU13	RGD	RGD:1303103
Bos taurus	SNU13	VGNC	VGNC:35087
Others	SNU13	NCBI

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