1. Gene
  2. Fasn - fatty acid synthase Gene

Fasn - fatty acid synthase Gene

中文名称:脂肪酸合酶

种属: Rattus norvegicus

基因 ID: 50671 | 基因类型: protein coding

关于 Fasn

Primary_assembly 10: 106,072,091-106,090,261 reverse strand.mRatBN7.2:CM026983.1

This gene has 2 transcripts (splice variants), 195 orthologues, 1 paralogue and is associated with 20 phenotypes. Biased expression in Adrenal (RPKM 37.2), Thymus (RPKM 361.4) and 5 other tissues.

功能概要

该基因编码的蛋白可启动 [acyl-carrier-protein] S-丙二酰基转移酶活性和相同的蛋白质结合活性。参与乙酰辅酶A代谢过程和脂肪酸生物合成过程。位于细胞质中。与人类 FASN(脂肪酸合成酶)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables [acyl-carrier-protein] S-malonyltransferase activity and identical protein binding activity. Involved in acetyl-CoA metabolic process and fatty acid biosynthetic process. Located in cytoplasm. Orthologous to human FASN (fatty acid synthase). [provided by Alliance of Genome Resources, Apr 2022]

Fasn 基因产物(1)

mRNA Protein Name
NM_017332.2 NP_059028.2 fatty acid synthase
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables [acyl-carrier-protein] S-malonyltransferase activity IMP
IMP: 通过突变表型推断
8940200 RGD
enables fatty acid synthase activity IDA
IDA: 通过直接分析推断
15715522 RGD
enables identical protein binding IPI
IPI: 通过物理相互作用推断
9047334 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
16054098 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in acetyl-CoA metabolic process IDA
IDA: 通过直接分析推断
18062843 RGD
involved in fatty acid biosynthetic process IDA
IDA: 通过直接分析推断
15715522 RGD
involved in response to nutrient IEP
IEP: 通过表达模式推断
26394137 RGD
involved in response to nutrient levels IEP
IEP: 通过表达模式推断
25943649 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
16054098 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Fasn 蛋白结构

PksD

PksD: COG3321 (0 - 1014)

PKS

PKS: cd00833 (1 - 403)

Methyltransf_12

Methyltransf_12: pfam08242 (1237 - 1336)

KR_1_FAS_SDR_x

KR_1_FAS_SDR_x: cd08954 (1310 - 1514)

PKS_ER

PKS_ER: smart00829 (1557 - 1847)

KR_1_FAS_SDR_x

KR_1_FAS_SDR_x: cd08954 (1869 - 2105)

entF

entF: cl35902 (2120 - 2317)

Thioesterase

Thioesterase: pfam00975 (2235 - 2494)

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  • 1600
  • 2000
  • 2505 a.a.
蛋白主名 其他名称

fatty acid synthase

type I FAS

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Fasn NCBI NCBI:2194