2. Gene
  3. ZFR - zinc finger RNA binding protein Gene

ZFR - zinc finger RNA binding protein Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：锌指 RNA 结合蛋白

种属: Homo sapiens

同用名: ZFR1; SPG71

基因 ID: 51663 | 基因类型: protein coding

关于 ZFR

Cytogenetic location: 5p13.3 Genomic coordinates (GRCh38): 5:32,354,350-32,444,740 (from NCBI)

This gene has 7 transcripts (splice variants), 247 orthologues, 14 paralogues and is associated with 1 phenotype. Ubiquitous expression in brain (RPKM 34.3), testis (RPKM 25.1) and 25 other tissues.

功能概要

该基因编码一种 RNA 结合蛋白，其特征在于其 DZF (与锌指相关的结构域) 结构域。编码的蛋白质可能在神经元中另一种 RNA 结合蛋白 Staufen 同系物 2 的核质穿梭中发挥作用。该基因的表达通过介导差异 MicroRNA 靶向的替代聚腺苷酸化来调节。已在患有胰腺癌的人类患者中观察到该基因的表达升高，并且该基因的敲低可能导致胰腺癌细胞的活力和侵袭性降低。[RefSeq 提供，2016 年 9 月]

This gene encodes an RNA-binding protein characterized by its DZF (domain associated with zinc fingers) domain. The encoded protein may play a role in the nucleocytoplasmic shuttling of another RNA-binding protein, Staufen homolog 2, in neurons. Expression of this gene is regulated through alternative polyadenylation that mediates differential MicroRNA targeting. Elevated expression of this gene has been observed in human patients with pancreatic Cancer and knockdown of this gene may result in reduced viability and invasion of pancreatic Cancer cells. [provided by RefSeq, Sep 2016]

ZFR 基因产物(1)

mRNA Protein Name
NM_016107.5 NP_057191.2 zinc finger RNA-binding protein
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
20195357 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ZFR 蛋白结构

zf-met

zf-met: Zinc-finger of C2H2 type (332 - 355)

zf-met

zf-met: Zinc-finger of C2H2 type (383 - 406)

zf-met

zf-met: Zinc-finger of C2H2 type (582 - 606)

DZF

DZF: DZF domain (790 - 1036)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1074 a.a.
蛋白主名 其他名称

zinc finger RNA-binding protein

M-phase phosphoprotein homolog

ZFR 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ZFR Q96KR1 SMAD2 Homo sapiens Q15796
Display Tech
20195357
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Autosomal Recessive Spastic Paraplegia Type 71

Spg71
Hereditary Spastic Paraplegia 23

Lison Syndrome

Spastic Paraparesis-Vitiligo-Premature Graying-Characteristic Facies Syndrome

Spastic Paraplegia 23

Spastic Paraplegia With Pigmentary Abnormalities

Spg23
Spastic Paraplegia 63, Autosomal Recessive

SPG63

Hereditary Spastic Paraplegia 63

Spastic Paraplegia 63

Autosomal Recessive Spastic Paraplegia 63

Autosomal Recessive Spastic Paraplegia Type 63

Paraplegia, Spastic, Type 63, Autosomal Recessive
Spastic Paraplegia 45, Autosomal Recessive

SPG45

Hereditary Spastic Paraplegia 45

Autosomal Recessive Spastic Paraplegia Type 45

Autosomal Recessive Spastic Paraplegia Type 65

Spg65

Autosomal Recessive Spastic Paraplegia 45

Paraplegia, Spastic, Type 45, Autosomal Recessive
Motor Neuron Disease

Anterior Horn Cell Disease

Motor Neuron Diseases

Mnd - [Motor Neurone Disease]

Lou Gehrig Disease

Creeping Palsy

Creeping Paralysis

Bulbar Motor Neuron Disease

Bulbar Syndrome

Anterior Horn Cell Disorder

Hereditary Motor Neuron Disease
Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Hereditary Spastic Paraplegia

Familial Spastic Paraplegia

Hereditary Spastic Paraparesis

Strumpell-Lorrain Disease

Familial Spastic Paraparesis

Hsp

Spg

Strümpell-Lorrain Disease

Spastic Paraplegia, Hereditary

French Settlement Disease

Strumpell-Lorrain Syndrome

Fsp

Spastic Paraplegia, Familial

Spastic Paraplegia Hereditary

Spastic Paraplegia 3, Autosomal Dominant

Spastic Paraparesis

Hereditary Spastic Paralysis

Familial Spastic Paralysis

Hereditary Spastic Ataxia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS16050 ZFR Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS16051 ZFR2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus ZFR RGD RGD:1311890
Mus musculus ZFR MGD MGI:1341890
Bos taurus ZFR VGNC VGNC:37171
Felis catus ZFR VGNC VGNC:67235
Macaca mulatta ZFR VGNC VGNC:79070
Canis familiaris ZFR VGNC VGNC:48620
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