2. Gene
  3. PRKCH - protein kinase C eta Gene

PRKCH - protein kinase C eta Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：蛋白激酶 Ceta

种属: Homo sapiens

同用名: PKCL; PKC-L; PRKCL; uORF2; nPKC-eta

基因 ID: 5583 | 基因类型: protein coding

关于 PRKCH

Cytogenetic location: 14q23.1 Genomic coordinates (GRCh38): 14:61,187,468-61,550,976 (from NCBI)

This gene has 27 transcripts (splice variants), 241 orthologues, 9 paralogues and is associated with 1 phenotype. Ubiquitous expression in lymph node (RPKM 18.8), spleen (RPKM 14.7) and 24 other tissues.

功能概要

蛋白激酶 C (PKC) 是一个丝氨酸和苏氨酸特异性蛋白激酶家族，可被钙和第二信使甘油二酯激活。 PKC 家族成员磷酸化多种蛋白质靶标，并且已知参与多种细胞信号通路。 PKC 家族成员还充当佛波酯 (一类肿瘤促进剂) 的主要受体。 PKC 家族的每个成员都有特定的表达谱，并被认为在细胞中发挥着独特的作用。该基因编码的蛋白质是 PKC 家族成员之一。它是一种钙非依赖性和磷脂依赖性蛋白激酶。它主要在上皮组织中表达，并已显示特异性存在于细胞核中。这种蛋白激酶可以通过激活 MAP 激酶 MAPK13 (p38delta) 激活的蛋白激酶级联来调节角质形成细胞分化，该级联靶向 CCAAT/增强子结合蛋白 alpha (CEBPA) 。它还被发现介导转谷氨酰胺酶 1 (TGM1) 基因的转录激活。该基因的突变与脑梗塞的易感性有关。[RefSeq 提供，2015 年 9 月]

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene. Mutations in this gene are associated with susceptibility to cerebral infarction. [provided by RefSeq, Sep 2015]

PRKCH 基因产物(8)

mRNA Protein Name
NM_006255.5 NP_006246.2 protein kinase C eta type
XM_024449661.2 XP_024305429.1 protein kinase C eta type isoform X4
XM_024449662.2 XP_024305430.1 protein kinase C eta type isoform X4
XM_011536957.2 XP_011535259.1 protein kinase C eta type isoform X6
XM_011536955.2 XP_011535257.1 protein kinase C eta type isoform X3
XM_047431586.1 XP_047287542.1 protein kinase C eta type isoform X5
XM_011536954.4 XP_011535256.1 protein kinase C eta type isoform X2
XM_047431585.1 XP_047287541.1 protein kinase C eta type isoform X1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables enzyme binding IPI
IPI: 通过物理相互作用推断
15632189 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
19114660 GOA
enables protein kinase activity IDA
IDA: 通过直接分析推断
34593629 GOA
enables protein serine/threonine kinase binding IPI
IPI: 通过物理相互作用推断
34593629 GOA
enables protein serine/threonine kinase inhibitor activity IDA
IDA: 通过直接分析推断
34593629 GOA
enables translation regulator activity IDA
IDA: 通过直接分析推断
19797084 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to amino acid starvation IDA
IDA: 通过直接分析推断
19797084 GOA
involved in negative regulation of glial cell apoptotic process IMP
IMP: 通过突变表型推断
11772428 GOA
involved in negative regulation of protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
34593629 GOA
involved in negative regulation of translation IDA
IDA: 通过直接分析推断
19797084 GOA
involved in negative regulation of translation IMP
IMP: 通过突变表型推断
34593629 GOA
involved in positive regulation of B cell receptor signaling pathway IMP
IMP: 通过突变表型推断
18780722 GOA
involved in positive regulation of NF-kappaB transcription factor activity IMP
IMP: 通过突变表型推断
21820409 GOA
involved in positive regulation of glial cell proliferation IMP
IMP: 通过突变表型推断
10806212 GOA
involved in positive regulation of translation in response to stress IDA
IDA: 通过直接分析推断
19797084 GOA
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
34593629 GOA
involved in protein phosphorylation IMP
IMP: 通过突变表型推断
22304920 GOA
involved in regulation of bicellular tight junction assembly IMP
IMP: 通过突变表型推断
19114660 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
15632189 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
15632189 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PRKCH 蛋白结构

C2

C2: C2 domain (12 - 101)

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (172 - 225)

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (246 - 297)

Pkinase

Pkinase: Protein kinase domain (355 - 613)

Pkinase_C

Pkinase_C: Protein kinase C terminal domain (635 - 679)

  • 0
  • 200
  • 400
  • 600
  • 683 a.a.
蛋白主名 其他名称

protein kinase C eta type

Protein uPEP2

PRKCH 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
PRKCH P24723 OCLN Canis familiaris Q28269
Anti Bait CoIP
19114660
种属间
PRKCH P24723 OCLN Canis familiaris Q28269
Anti Tag CoIP
19114660
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Glioblastoma

Glioblastoma Multiforme

Gbm

Adult Glioblastoma Multiforme

Grade Iv Adult Astrocytic Tumor

Primary Glioblastoma Multiforme

Spongioblastoma Multiforme

Adult Glioblastoma

Primary Glioblastoma
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis
Stroke, Ischemic

Cerebral Infarction

Stroke

Ischemic Stroke

Cerebrovascular Accident

Cerebral Infarction, Susceptibility To

Stroke, Ischemic, Susceptibility To

Cerebral Infarct

Ischemic Stroke, Susceptibility To

Stroke, Susceptibility To

Cva - Cerebral Infarction

ISCHSTR

Ischemic Cerebrovascular Accident
Amphetamine Abuse
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11131 PRKCH Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS11132 Prkch Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS11133 Prkch Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus PRKCH MGD MGI:97600
Canis familiaris PRKCH VGNC VGNC:44981
Rattus norvegicus PRKCH RGD RGD:621888
Bos taurus PRKCH VGNC VGNC:33332
Macaca mulatta PRKCH VGNC VGNC:84424
Felis catus PRKCH VGNC VGNC:104609
Others PRKCH NCBI
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